Diabetes mellitus promotes periodontal destruction in children

Lalla, Evanthia; Cheng, Bin; Lal, Shantanu; Kaplan, Selma; Softness, Barney; Greenberg, Ellen; Goland, Robin; Lamster, Ira B.

doi:10.1111/j.1600-051x.2007.01054.x

Cited by 179 publications

(197 citation statements)

References 25 publications

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“…Indeed, several studies have shown that the prevalence, severity, and progression of periodontal diseases are significantly increased in diabetics, and the pathology is considered an important risk factor for periodontitis (3). The study of Lalla et al (4) showed an association between diabetes and the increased risk for periodontal destruction even very early in life. Flow rate and composition of saliva are crucial for the maintenance of oral cavity health, and both have been found altered in diabetic subjects, although with contradictory findings.…”

mentioning

confidence: 99%

Alterations of the Salivary Secretory Peptidome Profile in Children Affected by Type 1 Diabetes

Cabras

Pisano

Mastinu

et al. 2010

Molecular & Cellular Proteomics

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The acidic soluble fraction of whole saliva of type 1 diabetic children was analyzed by reversed phase (RP) 1 -HPLC-ESI-MS and compared with that of sex-and age-matched control subjects. Salivary acidic proline-rich phosphoproteins (aPRP), histatins, ␣-defensins, salivary cystatins, statherin, proline-rich peptide P-B (P-B), betathymosins, S100A8 and S100A9*(S100A9* corresponds to S100A9 vairant lacking the first four amino acids), as well some naturally occurring peptides derived from salivary acidic proline-rich phosphoproteins, histatins, statherin, and P-B peptide, were detected and quantified on the basis of the extracted ion current peak area. The level of phosphorylation of salivary acidic proline-rich phosphoproteins, histatin-1 (Hst-1), statherin and S100A9* and the percentage of truncated forms of salivary acidic proline-rich phosphoproteins was also determined in the two groups. The study revealed that statherin, proline-rich peptide P-B, P-C peptide, and histatins, were significantly less concentrated in saliva of diabetic subjects than in controls, while concentration of ␣-defensins 1, 2 and 4 and S100A9* was higher. The low concentration of P-C peptide was paralleled by high levels of some of its fragments. On the whole, the study highlighted the severe impairment of the repertoire of peptides involved in the safeguard of the oral cavity in children who have diabetes, as well as an higher concentration of the proinflammatory mediator S100A9* with respect to healthy children. Molecular & Cellular Proteomics 9:2099 -2108, 2010.Type 1 diabetes mellitus is a disease with universal distribution, affecting all populations (1) with an incidence increasing in Europe (2). Because type 1 diabetes involves many organs and tissues, signs and symptoms of diabetes can occur in the oral cavity. Indeed, several studies have shown that the prevalence, severity, and progression of periodontal diseases are significantly increased in diabetics, and the pathology is considered an important risk factor for periodontitis (3). The study of Lalla et al. (4) showed an association between diabetes and the increased risk for periodontal destruction even very early in life. Flow rate and composition of saliva are crucial for the maintenance of oral cavity health, and both have been found altered in diabetic subjects, although with contradictory findings. For instance, several studies reported a reduced resting salivary flow rate in adults and children who have type 1 diabetes with respect to healthy subjects (5-10), but it was also observed that stimulated saliva of diabetics and controls did not significantly differ (11,12). Total protein concentration of saliva was found either increased or not affected by the diabetic status. Lopez et al. (9) reported higher urea and total protein salivary content in diabetic children than in controls. Conversely, a study on 35 adult insulin-dependent diabetics demonstrated that they did not show a decreased saliva concentration of several innate antimicrobial factors (lysozyme, lactoferri...

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confidence: 99%

Alterations of the Salivary Secretory Peptidome Profile in Children Affected by Type 1 Diabetes

Cabras

Pisano

Mastinu

et al. 2010

Molecular & Cellular Proteomics

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“…Most of the previous studies in children with systemic diseases especially diabetes demonstrating higher periodontal problems (15,16). The risk for periodontal destruction increased with diabetes (5).Thus, control of the systemic conditions is of importance for periodontal health.…”

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confidence: 99%

Periodontal health status of children with type 1 diabetes mellitus

Gökmenoğlu¹,

Bavbek²,

Gürel³

et al. 2017

J Turgut Ozal Med Cent

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Aim: Type 1 diabetes mellitus (DM1) is the most common chronic disease in children and adolescents. The purpose of this study was to determine the relationship between Type 1 diabetes mellitus and periodontal health and also the effect of metabolic control level on both periodontal and dental health. Material and Methods: A Total of, 152 patients, of which 76 subjects with type 1 diabetes (DM1) and 76 healthy individuals were participated in this study. The subjects were also categorized with regard to gender and metabolic control levels. Periodontal health was assessed by recording plaque index (PI), gingival index (GI), pocket depth (PD) and bleeding on probing (BOP); while the dental status was determined by Decayed, Missing and Filled Teeth index (DMFT). Results: All periodontal scores were found to be significantly higher in DM1 group, whereas DMFT scores were similar in DM1 group and healthy controls. The glycemic control levels did not seem to have an impact on periodontal parameters (PI, GI, PD, BoP) and DMFT scores. Also, there were no statistically significant correlations between periodontal parameters and DMFT scores, and HbA1c values. Conclusion: Diabetes seems to be associated with poor periodontal health status regardless of the metabolic control level in adolescents, but not with increased caries risk.

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“…Children with type 1 or insulin dependent diabetics mellitus, resulting from autoimmune destruction of the insulin producing β cells of the pancreas, had increased attachment loss and bone loss compared with controls despite similar plaque levels [13]. The association seems to be bidirectional in many studies.…”

Section: Risk Factors Of Periodontitismentioning

confidence: 99%

Periodontitis- A Review

Shah¹

2017

Med Clin Rev

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The early form of periodontitis is gingivitis where inflammatory changes including bleeding and swelling are restricted to marginal gingiva and surrounding connective tissue, without the involvement of periodontal ligament. Periodontitis occurs when inflammatory changes reach the periodontal ligament and alveolar bone ultimately leading to tooth loss. The underlying cause of the disease is the presence of a polymicrobial biofilm that forms as plaque on the tooth surface and the resulting host response that this plaque induces. Inflammatory responses are initiated by a number of late stage colonizers and the virulence factors they produce. Among these late stage pathogens is P. gingivalis, a Gram negative, asacchrolytic bacterium with a large arsenal of virulence factors. P. gingivalis produces up to 13 virulence factors involved in host evasion and 21 virulence factors involved in tissue destruction. The presence of these virulence factors induces the production of proinflammatory chemokine and cytokine responses often seen in the saliva and gingival crevicular fluid of individuals with periodontitis.

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Diabetes mellitus promotes periodontal destruction in children

Abstract: These findings demonstrate an association between diabetes and an increased risk for periodontal destruction even very early in life, and suggest that programmes to address periodontal needs should be the standard of care for diabetic youth.

Cited by 179 publications

References 25 publications

Alterations of the Salivary Secretory Peptidome Profile in Children Affected by Type 1 Diabetes

Alterations of the Salivary Secretory Peptidome Profile in Children Affected by Type 1 Diabetes

Periodontal health status of children with type 1 diabetes mellitus

Periodontitis- A Review

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