Diabetes mellitus type 3c screening by patients with chronic pancreatitis

Kovacheva-Slavova, Mila; Mitova-Siminkovitch, Sylvie; Vladimirov, Borislav; Genov, Jordan; Gecov, Plamen; Mitova, R

doi:10.1016/j.pan.2015.05.281

Cited by 2 publications

(3 citation statements)

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“…In addition to bone metabolism, vitamin D is a factor in the development of pancreatic fibrosis and atrophy, cardiovascular and autoimmune diseases, type 1 and 2 diabetes mellitus, and contributes to an increased overall mortality [104,105].…”

Section: Pancreatic Exocrine Insufficiency Treatmentmentioning

confidence: 99%

Up-To-Date View on the Clinical Manifestations and Complications of Chronic Pancreatitis

Kovacheva-Slavova¹,

Getsov²,

Vladimirov³

et al. 2019

Pancreatitis

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Chronic pancreatitis is an inflammatory disease that causes irreversible anatomical changes including infiltration of inflammatory cells, fibrosis and pancreatic calcification with destruction of the structure of the gland, leading to abdominal pain, endocrine and exocrine dysfunction. Pancreatic exocrine insufficiency (PEI) prevalence in chronic pancreatitis varies between 40 and 94%. PEI is diagnosed by direct and indirect tests. Nutritional status is assessed by anthropometric indicators; laboratory tests-hemoglobin, plasma proteins (albumin, prealbumin, retinol-binding protein, transferrin), fat-soluble vitamins A, D, E, K; micronutrients. Pancreatic enzyme replacement therapy (PERT) is a fundamental part of PEI treatment. An optimal PERT could prevent serious PEI complications such as metabolic bone disease, adverse cardiovascular events, cachexia, poor quality of life and mortality. A periodic screening for PEI complications with a respect to their primary and secondary prophylaxis is mandatory. Diabetes mellitus secondary to pancreatic disease is defined as pancreatogenic diabetes or type 3c diabetes mellitus. Patients with chronic pancreatitis are at increased risk for pancreatic cancer influenced by smoking, alcohol abuse, chronic inflammation and pancreatic stellate cells over-proliferation. However, chronic pancreatitis could be further complicated with splenic vein thrombosis, pseudocysts, duodenal or biliary obstruction, pseudoaneurysm and pancreatic duct stones which might require endoscopic or surgical treatment.

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Section: Pancreatic Exocrine Insufficiency Treatmentmentioning

confidence: 99%

Up-To-Date View on the Clinical Manifestations and Complications of Chronic Pancreatitis

Kovacheva-Slavova¹,

Getsov²,

Vladimirov³

et al. 2019

Pancreatitis

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show abstract

“…According to recent analysis, PC incidence and death rates in both men and women are increasing. Patients with CP have a markedly increased with 2.3 to 18.5-fold risk of malignancy, which is higher in younger cancer cases (1)(2)(3)(4). Two forms of CP (tropical and hereditary pancreatitis) more often are complicated with PC.…”

Section: Introductionmentioning

confidence: 99%

“…Diabetes mellitus secondary to CP is known as type 3c or pancreatogenic. Endocrine pancreatic insufficiency is a later CP manifestation, which is well-established PC risk factor (1)(2)(3). A high proportion of CP patients are tobacco and alcohol users.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic cancer as a complication of chronic pancreatitis – diagnostic approach

Getsov

2019

ijmsci

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Patients with underlying chronic pancreatitis (CP) are at increased risk of pancreatic cancer (PC) development. The pathogenesis of the neoplastic transformation remains unclear. However, chronic inflammation, pancreatic stellate cells over-proliferation and genetic alterations play a major role in carcinogenesis progression. Early diagnosis and differentiation between benign and malignant disease is of a great importance. Better understanding the connection of the two entities could provide new therapeutic options.

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Diabetes mellitus type 3c screening by patients with chronic pancreatitis

Cited by 2 publications

References 0 publications

Up-To-Date View on the Clinical Manifestations and Complications of Chronic Pancreatitis

Up-To-Date View on the Clinical Manifestations and Complications of Chronic Pancreatitis

Pancreatic cancer as a complication of chronic pancreatitis – diagnostic approach

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