Diabetes mellitus with normal renal function is associated with anaemia

Grossman, Chagai; Dovrish, Zamir; Koren‐Morag, Nira; Bornstein, Gil; Leibowitz, Avshalom

doi:10.1002/dmrr.2491

Cited by 35 publications

(28 citation statements)

References 34 publications

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“…Of note, in the 50-to 64-year-old group the prevalence in men rises to 4.4% and the women's rates drop by half to 6.8% [16]. Our finding of 4.4% prevalence is also consistent with a recent cohort study of about 30,000 Swedish participants aged 44-73 which showed a prevalence of anemia of 3.8% [3], and a small Israeli cohort of similar subjects who attended a periodic medical examination clinic and had a prevalence of anemia of 2.7%, in non-diabetics [17]. Data regarding longitudinal assessment of anemia development in the general population are lacking in the literature.…”

Section: Discussionsupporting

confidence: 93%

Predicting the emergence of anemia — A large cohort study

Gafter‐Gvili

Cohen

Avni

et al. 2015

European Journal of Internal Medicine

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Section: Discussionsupporting

confidence: 93%

Predicting the emergence of anemia — A large cohort study

Gafter‐Gvili

Cohen

Avni

et al. 2015

European Journal of Internal Medicine

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“…The National Kidney Foundation's clinical practice guidelines define anemia as a hemoglobin (Hb) concentration lower than 13.5 g/dL for adult men and less than 12.0 g/dL for adult women [14]. However, anemia develops earlier in the course of CKD among patients with DM [15][16][17] and the severity of anemia tends to be more marked in these patients compared to nondiabetic subjects, regardless of the stage of CKD, while this difference is even most prominent among CKD stage 3 patients [18][19][20][21]. Several studies have demonstrated the importance of early detection of anemia in patients with T1DM and T2DM [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Less known pathophysiological mechanisms of anemia in patients with diabetic nephropathy

Παππά¹,

Dounousi

Duni

et al. 2015

Int Urol Nephrol

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Diabetes mellitus (DM) is currently considered a modern global epidemic, and diabetic nephropathy (DN) is the most common cause of chronic kidney disease (CKD). Anemia is one of the most significant complications of CKD, and it is mainly attributed to insufficient erythropoietin (EPO) production. However, anemia develops earlier in the course of CKD among patients with DM, and the severity of anemia tends to be more marked in these patients compared to nondiabetic subjects, regardless of the stage of CKD. In this review, we focus on the "less known" complex interacting mechanisms which are involved in the pathophysiology of anemia associated with DN. Although the major cause of anemia in DN is considered to be an inappropriate response of the plasma EPO concentration to anemia, several other possible mechanisms have been suggested. Glomerular hyperfiltration, proteinuria, renal tubular dysfunction and interstitial fibrosis are among the main culprits. On the other hand, systemic effects such as chronic inflammation, autonomic neuropathy and the renin-angiotensin system are also involved. Finally, several medications are considered to aggravate anemia associated with DN. Since anemia is an important predictor of quality of life and is implicated in the increased burden of cardiovascular morbidity and mortality, further research is required to elucidate its pathogenesis in diabetic patients.

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“…In Current Topics in Anemiathe cohort of >9000 patients without renal disease, DM was an independent determinant of Hb levels [24]. Many factors have been suggested additionally contributing to the pathogenesis of anemia in DM patients, such as erythropoietin deficiency due to efferent sympathetic denervation of the kidney in diabetic neuropathy, chronic inflammatory reaction leading to functional iron deficiency, non-selective urinary protein excretion leading to transferrin and erythropoietin loss and the use of RAAS blockers [5,25].…”

Section: Anemia In Chronic Kidney Diseasementioning

confidence: 99%

“…Anemia has been found in about 10% of DM patients with normal kidney function [24]. In Current Topics in Anemiathe cohort of >9000 patients without renal disease, DM was an independent determinant of Hb levels [24].…”

Section: Anemia In Chronic Kidney Diseasementioning

confidence: 99%

See 1 more Smart Citation

Anemia in Chronic Kidney Disease and After Kidney Allotransplantation (Systematic Review)

Milovanov¹,

Lysenko²,

Milоvаnоvа³

et al. 2018

Current Topics in Anemia

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Anemia in chronic kidney disease (CKD) has been recognized as a separate independent risk factor of cardiovascular (CV) events. The aim of the review is to provide a literature summary concerning early diagnosis and treatment of anemia in CKD that may be useful for clinicians and contribute to decrease CV mortality. Literature searches were made in such major databases as: PubMed, Medline, Embase, Cochrane Library, CINAHL, Wiley Online Library, Scopus, Web of Science, e-library, and website of WHO. This search encompassed original articles, systematic reviews, and meta-analyses relevant to CKD and anemia over recent 15 years. A total of 54 references from 562 reviewed articles were selected as they met to the search criteria (anemia and CKD, including diabetes mellitus, systemic diseases and post-transplant anemia). The publications included 27 randomized controlled trials, 20 experimental studies representing new data on the links of CKD anemia and cardiovascular risk markers (cytokines, Klotho, fibroblast growth factor (FGF-23), hyperglycemia, hypoalbuminemia and some others), 4 systematic reviews and 3 clinical practice guidelines. The main attention was devoted to the analysis of the studies provided an early diagnosis of anemia, an ability to minimize the factors contributing to its severity that have allowed to improve CV and total outcomes and to reduce costs of hospital treatment of CKD patients with anemia.

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Diabetes mellitus with normal renal function is associated with anaemia

Abstract: Anaemia is more common in diabetic patients even when eGFR > 60 mL/min.

Cited by 35 publications

References 34 publications

Predicting the emergence of anemia — A large cohort study

Predicting the emergence of anemia — A large cohort study

Less known pathophysiological mechanisms of anemia in patients with diabetic nephropathy

Anemia in Chronic Kidney Disease and After Kidney Allotransplantation (Systematic Review)

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