Diabetes of the Exocrine Pancreas Related to Hereditary Pancreatitis, an Update

Ramalho, Gabriel Xavier; Dytz, Márcio Garrison

doi:10.1007/s11892-020-01299-8

Cited by 8 publications

(5 citation statements)

References 95 publications

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“…Diabetes is the most common metabolic disease, which is characterized by partial or complete destruction of pancreatic cells leading to insulin deficiency [1]. Diabetic patients have impaired pancreatic islet function at a young age and may require lifelong insulin therapy [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Tresiba Combined with Six Ingredient Rehmannia Pill in the Treatment of Type 2 Diabetes

Li¹,

He²

2022

Journal of Healthcare Engineering

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Objective. Insulin replacement therapy is the main treatment method for type 1 diabetes, and adjuvant comprehensive treatment to reduce the complications of diabetes is still the focus of research. The purpose of this study is to explore the clinical efficacy of Tresiba combined with Ingredient Rehmannia Pill in the treatment of type 1 diabetes. Methods. A total of 216 patients with type 2 diabetes admitted to our hospital from January 2019 to July 2019 were enrolled in this study. Patients in the control and observation groups were treated with Tresiba and Tresiba combined with Ingredient Rehmannia Pill, respectively. The change of TCM symptom score, blood glucose level and fasting insulin level before and after treatment were evaluated, and the insulin resistance index was calculated to observe the adverse reactions of patients. Results. After treatment, the TCM syndrome scores of the two groups decreased significantly, and the TCM syndrome scores of the observation group were significantly lower than those of the control group. The fasting blood glucose, 2 h postprandial blood glucose and insulin resistance index of the observation group were lower than those of the control group. The levels of FBG, 2 hBG and HbA1C in the observation group were significantly lower than those in the control group. The total effective rate of the observation group was 91.7%, which was significantly higher than that of the control group (77.1%). The adverse reactions of patients in the observation group were slightly more than those in the control group. Conclusion. Our study demonstrated that Ingredient Rehmannia Pill combined with Tresiba is effective in the treatment of type 2 diabetes, providing alternative therapies for the treatment of diabetes.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Tresiba Combined with Six Ingredient Rehmannia Pill in the Treatment of Type 2 Diabetes

Li¹,

He²

2022

Journal of Healthcare Engineering

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“…Metformin and insulin have been the most commonly used drugs in DEP, which is consistent with several recent expert recommendations [ 5 – 10 ], while other guidelines continue to emphasize insulin alone [ 11 ]. Initial use of metformin or insulin has also been recommended for DEP associated with hereditary pancreatitis—generally considered to be a sub-type of chronic pancreatitis [ 12 ]. Of note, insulin remains the main recommended treatment for CFRD [ 13 ].…”

Section: Key Pharmacological Management Considerationsmentioning

confidence: 99%

Diabetes of the Exocrine Pancreas: Implications for Pharmacological Management

Goodarzi

Petrov

2023

Drugs

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Post-pancreatitis diabetes mellitus, pancreatic cancer-related diabetes, and cystic fibrosis-related diabetes are often underappreciated. As a result, a substantial proportion of people with these sub-types of diabetes receive antidiabetic medications that may be suboptimal, if not harmful, in the context of their underlying disease of the exocrine pancreas. The present article delineates both classical (biguanides, insulin, sulfonylureas, α-glucosidase inhibitors, thiazolidinediones, and meglitinides) and newer (glucagon-like peptide-1 receptor agonists, amylin analogs, dipeptidyl peptidase-4 inhibitors, sodium-glucose co-transporter-2 inhibitors, D2 receptor agonists, bile acid sequestrants, and dual glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide receptor co-agonists) therapies and provides recommendations for managing people with diabetes of the exocrine pancreas based on the most up-to-date clinical evidence. Also, several emerging directions (lipid-enriched pathways, Y4 receptor agonism, glucagon-like peptide-1 and glucagon receptor co-agonism) are presented with a view to informing the process of new drug discovery and development.

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“…Sometimes you may also need to take antacids to keep your stomach from breaking down the pancreatic enzymes before they start to work. Administration of a pancreatic polypeptide is a promising new treatment ( Ramalho and Dytz, 2020 ). In addition to taking medications, symptoms can be relieved by following a proper diet.…”

Section: Pancreatic Exocrine Insufficiencymentioning

confidence: 99%

Pancreas—Its Functions, Disorders, and Physiological Impact on the Mammals’ Organism

Karpińska

Czauderna

2022

Front. Physiol.

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This review aimed to analyze the scientific literature on pancreatic diseases (especially exocrine pancreatic insufficiency). This review also describes the correlation between the physiological fitness of the pancreas and obesity. The influence of the pancreatic exocrine function on the development of the organism of adults and adolescents was also described. The results of piglet studies available in the literature were cited as an established model used to optimize treatments for pancreatic diseases in humans. The pancreas has an exocrine and hormonal function. Consequently, it is one of the key internal organs in animals and humans. Pancreatic diseases are usually severe and particularly troublesome. A properly composed diet and taken dietary supplements significantly improve the patient’s well-being, as well as the course of the disease. Therefore, a diet and a healthy lifestyle positively affect maintaining the optimal physiological efficiency of the pancreas.

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Diabetes of the Exocrine Pancreas Related to Hereditary Pancreatitis, an Update

Cited by 8 publications

References 95 publications

Evaluation of Tresiba Combined with Six Ingredient Rehmannia Pill in the Treatment of Type 2 Diabetes

Evaluation of Tresiba Combined with Six Ingredient Rehmannia Pill in the Treatment of Type 2 Diabetes

Diabetes of the Exocrine Pancreas: Implications for Pharmacological Management

Pancreas—Its Functions, Disorders, and Physiological Impact on the Mammals’ Organism

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