Diabetes on sepsis outcomes in non-ICU patients: A cohort study and review of the literature

Akinosoglou, Karolina; Καψοκώστα, Γεωργία; Mouktaroudi, Maria; Rovina, Nikoletta; Kaldis, Vasileios; Stefos, Aggelos; Kontogiorgi, Marina; Giamarellos‐Bourboulis, Evangelos J.; Gogos, Charalambos

doi:10.1016/j.jdiacomp.2020.107765

Cited by 12 publications

(12 citation statements)

References 54 publications

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“…Both NLR and RDW have been found to be correlated with the prognosis of sepsis patients, and both have been proven to be independent predictors of inpatient mortality in sepsis patients [ 14 ]. However, the impact of both on the prognosis of emergency patients with sepsis is still controversial [ 15 ]. For this reason, this paper starts a preliminary discussion on this aspect.…”

Section: Discussionmentioning

confidence: 99%

The Value of Neutrophil/Lymphocyte Ratio Combined with Red Blood Cell Distribution Width in Evaluating the Prognosis of Emergency Patients with Sepsis

Lin

Zhang

Tang

et al. 2022

Emergency Medicine International

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Sepsis is a dysfunction of various organs caused by a dysfunctional host response induced by infection. In recent years, the mortality rate of sepsis patients, especially the mortality rate of septic shock patients still remains high. Due to the complexity and heterogeneity of sepsis, there is currently a lack of clinical biomarkers that can be widely used for the early assessment of sepsis. In order to find more concise and accurate biomarkers for timely and adequate intervention in sepsis, we explored the value of neutrophil/lymphocyte ratio (NLR) combined with red blood cell distribution width (RDW) in assessing the prognosis of emergency sepsis patients. The results showed that NLR and RDW were closely related to the prognosis of emergency sepsis patients. The combination of the two can evaluate the prognosis of patients with emergency sepsis, which deserves close attention from clinicians.

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Section: Discussionmentioning

confidence: 99%

The Value of Neutrophil/Lymphocyte Ratio Combined with Red Blood Cell Distribution Width in Evaluating the Prognosis of Emergency Patients with Sepsis

Lin

Zhang

Tang

et al. 2022

Emergency Medicine International

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“…The effect of diabetes mellites on infection especially among elderlies is well known, since diabetic patient have higher frequency for upper respiratory tract infection, urinary tract, skin, fungal and hospital acquired infection. Even of its known effect of impairing immunity and vasculature, the relation between diabetic patient and sepsis were not established, one cohort study done on non-ICU patients revealed that no difference in primary outcomes of septic patients with type 2 Diabetes mellitus (T2D) when compared to non-diabetics [6]. We present a case of acute DIC, sepsis, Upper GI bleeding and AKI in patient known to have diabetes and ACS.…”

Section: Introductionmentioning

confidence: 85%

DIC-Induced Septic Shock in A Patient with Multiple Comorbidities: A Case Report

Quteineh

Obeid

Al-Shami

et al. 2022

Preprint

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“…As extensively discussed [ 8 ], a clear association between DM and increased infection-related mortality/morbidity is still uncertain. A recent review [ 6 ] investigating this specific topic has reported no difference in hospital mortality between diabetic and non-diabetic individuals, concluding that, rather than DM per se, DM-related co-morbidities and long-term complications might drive worse outcomes. Compared to healthy individuals, septic patients are connoted by the increased production of acute phase proteins, such as C reactive protein (CRP).…”

Section: Treatment-associated Infectionsmentioning

confidence: 99%

“…Individuals with DM are at a greater risk of hospitalization and mortality due to viral, bacterial, and fungal infections [ 5 ]. However, recent evidence indicates that DM does not represent a significant risk factor for poor survival in patients with sepsis, regardless of intensive care unit (ICU) admission [ 6 , 7 ]. Nevertheless, DM and sepsis remain important causes of morbidity and mortality worldwide, and DM patients represent the largest population experiencing post-sepsis complications [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Insight on Infections in Diabetic Setting

et al. 2023

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The correlation between diabetes mellitus and infectious diseases is widely recognized. DM patients are characterized by the impaired function of the immune system. This translates into the occurrence of a variety of infections, including urinary tract, skin and surgical site infections, pneumonia, tuberculosis, and, more recently, SARS-CoV-2. Hyperglycemia has been identified as a relevant factor contributing to unfavorable outcomes in hospitalized patients including SARS-CoV-2 patients. Several studies have been performed proving that to maintain the proper and stringent monitoring of glycemia, a balanced diet and physical activity is mandatory to reduce the risk of infections and their associated complications. This review is focused on the mechanisms accounting for the increased susceptibility of DM patients to infections, with particular attention to the impact of newly introduced hypoglycemic drugs in sepsis management.

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Diabetes on sepsis outcomes in non-ICU patients: A cohort study and review of the literature

Cited by 12 publications

References 54 publications

The Value of Neutrophil/Lymphocyte Ratio Combined with Red Blood Cell Distribution Width in Evaluating the Prognosis of Emergency Patients with Sepsis

The Value of Neutrophil/Lymphocyte Ratio Combined with Red Blood Cell Distribution Width in Evaluating the Prognosis of Emergency Patients with Sepsis

DIC-Induced Septic Shock in A Patient with Multiple Comorbidities: A Case Report

Insight on Infections in Diabetic Setting

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