Diabetes risk in women with gestational diabetes mellitus and a history of polycystic ovary syndrome: a retrospective cohort study

Bond, Rachel; Pace, Romina; Rahme, Elham; Dasgupta, Kaberi

doi:10.1111/dme.13444

Cited by 8 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of GDM in PCOS patients has reached about 32.17% [22] . With the changes in human life patterns and survival styles, the incidence of GDM complicated by PCOS is increasing, and the early prediction, prevention, and treatment of GDM in PCOS patients are urgent [23] . The onset of GDM involves factors such as heredity, immunity, hormones, trace elements, mood, hypertension, etc, but there are no reliable predictors [24] .…”

Section: Discussionmentioning

confidence: 99%

The risk factors of gestational diabetes mellitus in patients with polycystic ovary syndrome

Liu

Zuo

et al. 2021

Medicine

View full text Add to dashboard Cite

The influencing factors of gestational diabetes mellitus (GDM) in the polycystic ovary syndrome (PCOS) patients remain unclear, we aimed to investigate the risk factors of GDM in patients with PCOS, to provide reliable evidence for the prevention and treatment of GDM in PCOS patients.PCOS patients treated in our hospital from January 1, 2019 to October 31, 2020 were included. The personal and clinical treatment details of GDM and no GDM patients were analyzed. Logistic regressions were performed to analyze the factors influencing the occurrence of GDM.A total of 196 PCOS patients were included, the incidence of GDM in patients with PCOS was 23.98%. There were significant differences in the age, body mass index, insulin resistance index, fasting insulin, testosterone, androstenedione, and sex hormonebinding protein between GDM and no GDM patients with PCOS (all P < .05), and no significant differences in the family history of GDM, the history of adverse pregnancy, and multiple pregnancies were found (all P > .05). Age ≥30 years (odds ratio (OR) 2.418, 95% confidence interval (CI) 1.181-3.784), body mass index ≥24 kg/m 2 (OR 1.973, 95%CI 1.266-3.121), insulin resistance index ≥22.69 (OR 2.491,, fasting insulin ≥22.71 mIU/L (OR 2.508, 95%CI 1.166-5.057), testosterone ≥2.85 nmol/L (OR 1.821, 95%CI 1.104-2.762), androstenedione ≥6.63 nmol/L (OR 1.954, 95%CI 1.262-2.844), sex hormone-binding protein <64.22 nmol/L (OR 1.497, 95%CI 1.028-2.016) were the independent risk factors of GDM in patients with PCOS (all P < .05). The incidence of preeclampsia, premature delivery, premature rupture of membranes, polyhydramnios, and postpartum hemorrhage in the GDM group was significantly higher than that of the no-GDM group (all P < .05). There was no significant difference in the incidence of oligohydramnios between the 2 groups (P = .057).

show abstract

Section: Discussionmentioning

confidence: 99%

The risk factors of gestational diabetes mellitus in patients with polycystic ovary syndrome

Liu

Zuo

et al. 2021

Medicine

View full text Add to dashboard Cite

show abstract

“…Polycystic ovary syndrome (PCOS) is a prevalent heterogeneous endocrine disorder that affects approximately 10% of women during reproductive age (Bozdag et al, 2016), and is characterized by features of biochemical and/or clinical hyperandrogenism, oligo-or anovulation and polycystic ovaries (Legro et al, 2013). Accumulating evidence suggests that PCOS might be the leading cause of anovulatory infertility (Legro et al, 2013), and could predispose affected women to increased risks of cardiometabolic comorbidities including type 2 diabetes, metabolic syndrome and cardiovascular disease (Bond et al, 2017;Celik et al, 2014;Kyrkou et al, 2016;Zhao et al, 2016), subsequently leading to a negative impact on healthrelated quality of life for patients with PCOS and a significant burden on the healthcare system (Barry et al, 2011). As a result, specific intervention with a target in the aetiology of PCOS is crucial and strongly recommended.…”

Section: Introductionmentioning

confidence: 99%

Circulating irisin in patients with polycystic ovary syndrome: a meta-analysis

Cai

Qiu

et al. 2018

Reproductive BioMedicine Online

View full text Add to dashboard Cite

“…Our initial search yielded 7970 publications, of which 109 articles were reviewed in full and 43 studies were included in the final analysis [3,11,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55]. Forty studies reported on T2DM [3,11,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43…”

Section: Resultsmentioning

confidence: 99%

The Risk for Glucose Intolerance after Gestational Diabetes Mellitus since the Introduction of the IADPSG Criteria: A Systematic Review and Meta-Analysis

Benhalima

Lens

Bosteels

et al. 2019

JCM

View full text Add to dashboard Cite

The aim of the study was to assess the postpartum risk for glucose intolerance since the introduction of the ‘International Association of Diabetes and Pregnancy Study Groups’ (IADPSG) criteria for gestational diabetes mellitus (GDM). Studies published since 2010 were included, which evaluated the risk for type 2 diabetes mellitus (T2DM), impaired glucose tolerance (IGT), and cardiovascular (CV) events in women with previous GDM compared to normal glucose tolerant women. We included forty-three studies, evaluating 4,923,571 pregnant women of which 5.8% (284,312) had a history of GDM. Five studies used IADPSG criteria (n = 6174 women, 1314 with GDM). The overall pooled relative risk (RR) for postpartum T2DM was 7.42 (95% CI: 5.99–9.19) and the RR for postpartum T2DM with IADPSG criteria was 6.45 (95% CI: 4.74–8.77) compared to the RR of 9.08 (95% CI: 6.96–11.85; p = 0.17) for postpartum T2DM based on other diagnostic criteria. The RR for postpartum IGT was 2.45 (95% CI: 1.92–3.13), independent of the criteria used. None of the available studies with IADPSG criteria evaluated the risk for CV events. Women with a history of GDM based on the IADPSG criteria have a similarly increased risk for postpartum glucose intolerance compared to GDM based on other diagnostic criteria. More studies with GDM based on the IADPSG criteria are needed to increase the quality of evidence concerning the long-term metabolic risk.

show abstract

Diabetes risk in women with gestational diabetes mellitus and a history of polycystic ovary syndrome: a retrospective cohort study

Cited by 8 publications

References 30 publications

The risk factors of gestational diabetes mellitus in patients with polycystic ovary syndrome

The risk factors of gestational diabetes mellitus in patients with polycystic ovary syndrome

Circulating irisin in patients with polycystic ovary syndrome: a meta-analysis

The Risk for Glucose Intolerance after Gestational Diabetes Mellitus since the Introduction of the IADPSG Criteria: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About