2015
DOI: 10.1080/21645515.2014.1004024
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Diabetes tolerogenic vaccines targeting antigen-specific inflammation

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Cited by 7 publications
(5 citation statements)
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“…The use of Tregs as a method to treat inflammation and autoimmune diseases has been proposed and well-received by scientists (30). Many clinical trials have proved that the use of vaccines to treat autoimmune diseases cannot effectively induce the production of antigen-specific Treg cells, thus inhibiting the role of pathological T cells.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The use of Tregs as a method to treat inflammation and autoimmune diseases has been proposed and well-received by scientists (30). Many clinical trials have proved that the use of vaccines to treat autoimmune diseases cannot effectively induce the production of antigen-specific Treg cells, thus inhibiting the role of pathological T cells.…”
Section: Discussionmentioning
confidence: 99%
“…Treg is a subset of CD4 + T cells which are characterized by the expression of transcription factor Foxp3 and helps to keep inflammation under control and lower the autoimmune disease risk in healthy individuals (30). They have been proved to maintain their regulatory functions for a long-term even in the absence of antigens that induced their generation and are stable and transferable (31), thereby permitting the expected induction of these cells to suppress unwanted immunity (13).…”
Section: Gad65 Phage Vaccine + Kyn Increases Cd4 + Cd25 + Treg Cells In the Nod Mouse Modelmentioning
confidence: 99%
“…Recently, the proof-of-concept for using RNA as tolerogenic vaccine was provided. In contrast to a vaccine augmenting immune responses against a pathogen, a tolerogenic vaccine is aimed at inducing tolerogenic responses to suppress or impair immunity against antigens, which in most cases are auto-antigens or allergens (Geng et al 2015) . Such vaccines may help in managing autoimmune diseases.…”
Section: Applications Of Rna Therapeuticsmentioning
confidence: 99%
“…Dendritic cells, a major type of innate immune cells involved in the regulation of T cell activation, inflammation, as well as tumor microenvironment [11], is considered to be a potent mediator bridging the innate and adaptive immune systems [12,13]. It could uptake and present the tumour-specific antigens to activate CD4 + or CD8 + T cell response [14].…”
Section: Regulation Of Innate Immune Response By Dubsmentioning
confidence: 99%