Diabetic encephalopathy: a concept in need of a definition

Type 3 Diabetes Reflects Disordered Lipid Metabolism in the Human Brain Related to Higher Degree of Unsaturated Fatty Acids Composition and is not Related to Body Mass Index

“…We recently observed based on ration of 16:0 to 18:0 fatty acids of brain homogenate that the saturation index for the Cholesterylesters for 16:0 was significantly higher in white matter of T2DM patients in comparison to white matter of the control group (P<0.05) [8]. Hence, in this manuscript we hypothetisize that there are structural changes in lipid brain composition of a T2DM patient group which can explain all earlier mentioned characteristics of diabetic encephalopathy [20]. The aim of this study is to compare the biochemical lipid composition in brain white and red matter between T2DM patients with controls.…”

“…Our major conclusion of this manuscript is that we have found a plausible mechanistic explanation related to the lipid composition of elderly with type-2 diabetes in relation to the earlier described cognitive impairment (depression, dementia, m-AD) which probably in the past is indicated with the one decade ago correctly chosen term "diabetic encephalopathy" [8,20], but which we now replace by the term "type-3 diabetes" [11]. Increasing the content of polyunsaturated fatty acids within cell membranes would increase the membrane fluidity, the number of insulin receptors and the action of insulin for muscle tissue.…”

“…Some of the "brain-diseases" as a consequence of T2DM are associated with the occurrence of well-described microvascular complications and can be associated with slowly progressive brain damage often referred as "diabetic encephalopathy" and are characterized by mild to moderate impairments in cognitive functioning [18]. The magnitude of these cognitive deficits appears mild to moderate, but can significantly hamper daily functioning in processes as attention and executive functioning, information processing, speed and memory, in this way adversely affecting quality of life [20]. So probably "Diabetic encephalopathy", is a term that encompasses functional impairment of cognition, cerebral cognition, cerebral signal conduction, neurotransmission and synaptic plasticity, and underlying structural pathology associated with T2DM.…”

Математична Модель Діабетичної Енцефалопатії В Діагностиці Ускладнених Форм Цукрового Діабету

“…Оригінальні дослідження /Original Researches/ should be noted that the clinical signs DE established on the basis of generally accepted classification [2]. Stage I installed in 56 (13.0 %) patients with type 1 DM and 28 (6.5 %) patients with type 2 DM, these were patients with moderate disease duration of 5-10 years.…”

“…Diabetes mellitus (DM) leads to a significant increase in mortality and deterioration of the quality of life of patients, primarily due to the development therein of cardiovascular complications [1][2][3]. Ischemic stroke occurs in patients with DM are two to four times, coronary heart disease is two to three times more often than in the general population.…”