Diabetic foot ulcer: A review

Kumudhavalli, M. V.; Kirteebala, Pawar; Archana, Pawar

doi:10.22271/phyto.2018.v7.isp6.1.12

Cited by 2 publications

(1 citation statement)

References 73 publications

(101 reference statements)

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“…Over the past three decades, oral dosage forms have arisen due to their considerable therapeutic advantages viz. ease of administration, patient compliance, and flexibility in formulation, etc [10]. Amongst assorted oral regio-selective/targeted drug delivery strategies accepted for the gastro-retentive drug delivery system (GRDDS), the floating drug delivery system (FDDS) holds a major account as the most clinically acknowledged and used formulations [11,12] for example misoprostol (Cytotech ® ), ofloxacin (Oflin OD ® ), diazepam (Valrelease ® ), ciprofloxacin (Cifran OD ® ), etc [13].…”

Section: Introductionmentioning

confidence: 99%

Silk industry waste protein: isolation, purification and fabrication of electrospun silk protein nanofibers as a possible nanocarrier for floating drug delivery

et al. 2020

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Amongst assorted regio-selective and targeted oral drug delivery strategies accepted for the gastro-retentive drug delivery system (GRDDS), the floating drug delivery system (FDDS) holds a major share as clinically accepted formulations. The major objective of the present investigation was to explore the silk industry waste protein, silk fibroin (SF) as a possible electrospun nanocarrier for the FDDS. In a nutshell, electrospinning (ES) is one of the flexible and astonishing strategies for the fabrication of porous electrospun nanofibers (NFs), which offers the potential to amend the floating profile, dissolution rate, solubility, and release patterns of the drug, etc as per compendial requirements. Looking at the prospects of floating SF-NFs preparation, we have isolated and lyophilized the SF from industrial waste cocoons and prepared drug-loaded SF single polymer nanofibers (SPN). Lafutidine (LF) being a good candidate for GRDDS selected as a model drug, which is an excellent proton pump inhibitor, mainly used in the treatment of gastric ulcers. Finally, the obtained LF loaded SF-NFs (LF-SF-NFs) were successfully analyzed for physicochemical characteristics, porosity, swelling index, antioxidant activity, mucoadhesion strength, floating properties, enzymatic degradation, and accelerated stability study, etc. Further, these LF-SF-NFs were evaluated for percent drug content, weight variation, in-vitro dissolution in 0.1 N hydrochloric acid (HCl, pH:1.2) and fasted state simulated gastric fluid (FSSGF), and accelerated stability study. It has shown significant floating time >18 h, about 99% ± 0.58% floating buoyancy with sustained release up to 24 h. LF-SF-NFs showed good compatibility, entrapment efficiency, antioxidant activity, mucoadhesion strength, enzymatic degradation, and long term stability. Soon, the essential floating and drug release profiles can claim single polymer (SF) based electrospun protein NFs as a possible novel oral nanocarrier for FDDS.

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Section: Introductionmentioning

confidence: 99%

Silk industry waste protein: isolation, purification and fabrication of electrospun silk protein nanofibers as a possible nanocarrier for floating drug delivery

et al. 2020

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Computer Aided Automatic Detection and Diagnosis System of Wound and Ulcer Care for Diabetic Patient

Prakash¹,

Jalil²,

Narmadha³

et al. 2022

IJEAT

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The diabetic wound healing process is a complex task under the category of B40 classification and below. The medical expenses are high in private wound specialist organizations compared to government hospitals. This article designed a computer-aided automatic detection and classification method for wound and ulcer care for diabetic patients using image processing techniques by Edge detection, colour scale of tissues, wound area calculation, and percentage calculation with GUI. The system results, Combination of edge detection methodology and 2-D boundary technique and design with the significant three tissues classification which is harmful and required immediate medical responses are Granulation, Fibrin and Necrotic values are used for wound area determination. The result of the system will help the patient immediately, which is classified as high or less severity.

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Diabetic foot ulcer: A review

Abstract: Innovation development and standardization of Novel Herbal Formulation

Cited by 2 publications

References 73 publications

Silk industry waste protein: isolation, purification and fabrication of electrospun silk protein nanofibers as a possible nanocarrier for floating drug delivery

Silk industry waste protein: isolation, purification and fabrication of electrospun silk protein nanofibers as a possible nanocarrier for floating drug delivery

Computer Aided Automatic Detection and Diagnosis System of Wound and Ulcer Care for Diabetic Patient

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