Diabetic Foot Ulcer

Farzamfar, Bardia; Nazari, Reza; Bayanolhagh, Saeed

doi:10.5772/55588

Cited by 5 publications

(7 citation statements)

References 126 publications

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“…Diabetic neuropathy and vasculopathy occurred when blood sugar is poorly controlled for prolonged periods of time. 3 Majority of those with DFU had DM for more than 10 years. 27 It is important to detect depression and anxiety in DM population as a whole as it affect compliance with the treatment regime leading to lower selfefficacy and to self-neglect, associated with higher morbidity, mortality and lower quality of life, even more in DFU group.…”

Section: Discussionmentioning

confidence: 99%

“…1 In general, Type 2 DM may result in various complications namely nephropathy, retinopathy, neuropathy and dermatopathy. 2 About 60% of diabetic foot ulcers are the result of underlying neuropathy 3 and vasculopathy, which retards the healing process. 2 Diabetic foot ulcer ("DFU") is an open wound commonly located on the foot that occurs in about 15% of patient with diabetes and approximately 4.3% had lower limb amputation.…”

Section: Depression Anxiety and Sexual Dysfunction In Patients With mentioning

confidence: 99%

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Depression, Anxiety and Sexual Dysfunction in Patients with Diabetes Mellitus With and Without Foot Ulcer

Husin

Sidi²,

Baharudin³

2017

imjm

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Introduction: Anxiety and depression are both associated with increased morbidity in diabetic population, especially those afflicted with foot ulcer, whereas Erectile Dysfunction (“ED”) and Female Sexual Dysfunction (“FSD”) are amongst the common complication found in diabetes. This study aimed to determine the prevalence of anxiety and depression as primary outcome and sexual dysfunction (“SD”) as a secondary outcome in diabetic patients with and without foot ulcer (“DFU”). Methods: A cross-sectional study was conducted in Hospital Raja Permaisuri Bainun Ipoh, Perak, where 164 diabetic patients were recruited for the purpose of this study. Hospital Anxiety and Depression Scale (“HADS”) were utilised to measure anxiety and depression. International Index for Erectile Function 5 (“IIEF-5”) and the Malay version of Female Sexual Function Index (“MVFSFI”) were used to detect SD. Simple and multiple logistic regressions were referred to in order to evaluate the factors associated with anxiety, depression and SD. Results: In the group with foot ulcer, 36.8% had depressive and anxiety risk respectively compared to without the foot ulcer, 37.5% and 38.5% respectively. Male gender (AOR=6.3,p=0.002,95%CI 1.975, 20.205) and having lower education status (AOR=6.0,p=0.018,95%CI1.36,26.59,) was associated with foot ulcer. High prevalence of SD found in foot ulcer group (52.6%,p=0.006). Those with depression (OR=4.421,95% CI 1.08,18.16,p=0.039) and male gender (OR=18.42,p<0.01,95%CI5.5,-61.62) predicts present of SD. Conclusion: Depression and anxiety prevalent were similar for both with and without diabetic foot ulcer. Several significant predictor factors were identified for DFU group, for anxiety and depression risk and for SD in a diabetes patient. Further studies are required to establish the directional nature of this relationship.

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Section: Discussionmentioning

confidence: 99%

Section: Depression Anxiety and Sexual Dysfunction In Patients With mentioning

confidence: 99%

Depression, Anxiety and Sexual Dysfunction in Patients with Diabetes Mellitus With and Without Foot Ulcer

Husin

Sidi²,

Baharudin³

2017

imjm

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“…Tre and BSA were used as they have previously demonstrated the ability to stabilize cytokines and other proteins. 25,26 MSA was studied to prevent potential immunogenic effects possible with BSA as the macrophages were extracted from mice. Concentrations were based off of the minimum values used by Farzamfar et al then increased to enhance stabilization.…”

Section: Film Castingmentioning

confidence: 99%

“…22 Some of the main challenges of working with cytokines is their transient nature (serum halflife of approximately 19 min 23 ) and their helical hydrophobic regions that promote aggregation, which can result in increased immunogenicity. 24 Studies have used a variety of agents to stabilize the tertiary structure of proteins and cytokines, including the disaccharide trehalose (Tre), 25,26 bovine serum albumin (BSA), 26 the phosphoprotein casein, 26 and human serum albumin. 27 Others have demonstrated success in stabilizing and delivering IL-4 using various biomaterial strategies, primarily as coatings for implants.…”

Section: Introductionmentioning

confidence: 99%

Stabilized Interleukin-4-Loaded Poly(lactic-co-glycolic) Acid Films Shift Proinflammatory Macrophages toward a Regenerative Phenotypein Vitro

Ziemba

D’Amato

MacEwen

et al. 2019

ACS Appl. Bio Mater.

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Macrophages are immune cells involved in wound healing and tissue regeneration; however, the sustained presence of proinflammatory macrophages in wound sites impairs healing. In this study, we shifted peritoneal macrophage polarization away from a proinflammatory (M1) phenotype through exposure to stabilized interleukin-4 (IL-4) in poly(lactic-co-glycolic acid) films in combination with topographical guidance from electrospun poly-L-lactic acid fibers. To our knowledge, this was the first study to stabilize IL-4 with bovine serum albumin (BSA) within a biomaterial. When IL-4 was coloaded with BSA for stabilization, we saw increased IL-4 bioactivity compared to no added stabilization, trehalose stabilization, or murine serum albumin stabilization. We observed increased elongation of peritoneal macrophages, increased RNA expression of anti-inflammatory marker arginase-1, increased ratio of interleukin-10/interleukin-12 p40 RNA, and decreased protein expression of proinflammatory markers (interleukin-12 p40 *

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“…One of the key problems associated with diabetes is peripheral vascular disease and wound ischaemia . Poor antibiotic penetration into tissues because of a lack of blood flow is another reason why antibiotics are so unsuccessful.…”

Section: New Horizons In Understanding the Microbiology Of Foot Diseasementioning

confidence: 99%

New horizons in the understanding of the causes and management of diabetic foot disease: report from the 2017 Diabetes UK Annual Professional Conference Symposium

et al. 2017

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Diabetes‐related foot disease remains a common problem. For wounds, classic teaching recommends the treatment of any infection, offloading the wound and ensuring a good blood supply, as well as ensuring that the other modifiable risk factors are addressed and optimized. There remain, however, several questions about these and other aspects of the care of diabetes‐related foot disease. Some of these questions are addressed in the present report; in particular, the impact of newer technologies in the identification of any organisms present in a wound, as well as the use of novel approaches to treat infections. The use of new remote sensing technology to identify people at risk of developing foot ulceration is also considered, in an attempt to allow early intervention and prevention of foot ulcers. The psychological impact of foot disease is often overlooked, but with an increasing number of publications on the subject, the cause‐and‐effect role that psychology plays in foot disease, such as ulcers and Charcot neuroarthropathy, is considered. Finally, because of heterogeneity in diabetic foot studies, comparing results is difficult. A recently published document focusing on ensuring a standardized way of reporting foot disease trials is discussed.

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Diabetic Foot Ulcer

Cited by 5 publications

References 126 publications

Depression, Anxiety and Sexual Dysfunction in Patients with Diabetes Mellitus With and Without Foot Ulcer

Depression, Anxiety and Sexual Dysfunction in Patients with Diabetes Mellitus With and Without Foot Ulcer

Stabilized Interleukin-4-Loaded Poly(lactic-co-glycolic) Acid Films Shift Proinflammatory Macrophages toward a Regenerative Phenotypein Vitro

New horizons in the understanding of the causes and management of diabetic foot disease: report from the 2017 Diabetes UK Annual Professional Conference Symposium

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