Diabetic Fracture Healing

Threaded Screw Head Inserts Improve Locking Plate Biomechanical Properties

“…Increased American Society of Anesthesiologists score, 1 inadequate blood supply, 2 infection, 3 soft tissue loss, 4 and diabetes 5 are among the list of factors that can result in protracted union after fracture. Delayed union results in longer biomechanical demands on implants and predisposes the implants to fatigue failure.…”

Percutaneous injection of bone marrow mesenchymal stem cells for ankle non-unions decreases complications in patients with diabetes

“…Clinically, the effect of diabetes has been discussed, and several studies [22][23][24][25][26] have reported a negative effect of diabetes, resulting in delayed healing and many complications in ankle fractures. Several experimental studies have shown that diabetes has a negative effect on fracture union capacity.…”

“…Prevalence of diabetes mellitus is increasing at an epidemic rate throughout the countries of the world [5]. Clinical studies have demonstrated a significantly higher incidence of delayed union, non-union, increased healing time and increased risk of infection of fractures [6][7][8][9][10][11] in diabetic patients compared with non-diabetic patients. One strategy to mitigate issues with wound healing and infection in diabetics is to use a percutaneous technique in which autologous, bone marrowderived concentrated cells are injected at the site of a nonunion [1].…”

Diabetic Foot

“…15 Non-weight bearing activities are critical with any fracture whether they are painless or not. Treatment involves casting with weight-bearing limitations.…”

“…It is imperative that the cycle of structural damage and inflammation be stopped to prevent further damage. 15 In a retrospective study sample of 78 subjects, researchers found that 6 of the 12 subjects with diabetes and Charcot disease had surgical ankle fusions that eventually developed closure. Patients with Charcot arthropathy usually required at least 3 additional months for healing.…”