Diabetic ketoacidosis associated with clozapine treatment

Mental Health Retrosight: Perspectives

“…The earliest evidence on the glucoregulatory effects of an SGA was published in 1994 as a letter to the editor .The letter described a case of severe and sustained hyperglycemia in a 41 year old patient with no prior history of diabetes or glucose intolerance who had been treated with clozapine for two months. Other case reports also reporting on clozapine's glucoregulatory effects were published later that year Koval, Rames et al 1994). The earliest evidence on clozapine's lipid effects was published between 1994 and 1996 when a group of researchers reported on increased serum triglyceride levels in clozapine-treated patients Ghaeli P 1995;Ghaeli and Dufresne 1996).…”