Diabetic nephropathy &amp;ndash; complications and treatment

Lim, Andy

doi:10.2147/ijnrd.s40172

Cited by 517 publications

(383 citation statements)

References 237 publications

(173 reference statements)

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“…Microalbuminuria or incipient nephropathy is the earliest clinical evidence of DN (ACR of 30-300 mg/g, equivalent to timed collections of 30-300 mg/24 hours). Progression to macroalbuminuria or overt nephropathy is heralded by a urinary albumin excretion of > 300 mg/24 hours or ACR > 300 mg/g and is more likely to be associated with the development of end-stage renal disease (Reutens 2013;Lim 2014). In addition to albuminuria, GFR was identified as the other diagnostic modality of DN (Tuttle et al 2014; Kim et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Clinical and biochemical aspects associated with diabetic nephropathy among type 2 diabetic males in Gaza strip

Mustafa

Yassin

2017

IJM

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Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and the published data on various aspects of the disease is rare in Gaza Strip. Objective: to investigate clinical and biochemical aspects associated with DN among type 2 diabetic males in Gaza Strip. Methods: The study comprised 150 type 2 diabetic males from Gaza Strip. Data were obtained from a questionnaire interview, patients' records, and biochemical analysis of blood and urine samples. Statistical analysis was performed using SPSS version 23. Results: The prevalence of DN was 71/150 (47.3%). Duration of diabetes in patients with DN was significantly higher than in patients without DN (p<0.001). Smoking, retinopathy, cardiovascular diseases (CVD) and neuropathy were significantly more frequent among patients with DN (p<0.05). Serum glucose, urea, creatinine, cholesterol and low-density lipoprotein cholesterol (LDL-C) were significantly higher, whereas high-density lipoprotein cholesterol (HDL-C) was significantly lower in patients with DN (p<0.05). Urinary albumin and Albumin/creatinine ratio (ACR) were 10 to 13 times higher in patients with DN. Conversely, glomerular filtration rate (GFR) was significantly lower in patients with DN (137.1±35.0 versus 187.8±70.8 ml/min/1.73m 2 , p<0.001). ACR showed significant positive correlations with duration of diabetes (r=0.311, p<0.001), glucose (r=0.308, p<0.001), urea (r=0.474, p<0.001), creatinine (r=0.356, p<0.001), cholesterol (r=0.307, p<0.001), LDL-C (r=0.319, p<0.001) and urinary albumin (r=0.942, p<0.001), and significant negative correlation with GFR (r=-0.297, p<0.001). The predicted factors of DN were duration of diabetes, smoking, retinopathy, CVD, neuropathy, glucose, urea, creatinine, cholesterol, LDL-C and GFR. The more to fewer effective predicted variables of ACR were urinary albumin, urea, creatinine, LDL-C, duration of diabetes, glucose, cholesterol and GFR. Conclusion: Management of some predicted factors of DN could delay the progression of the disease.

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Section: Introductionmentioning

confidence: 99%

Clinical and biochemical aspects associated with diabetic nephropathy among type 2 diabetic males in Gaza strip

Mustafa

Yassin

2017

IJM

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“…Diabetes leads to small blood vessels injury. When kidney blood vessels injured, the kidney cannot clean blood properly; the body will retain more water and salt than it should, the presence of protein in urine may occur [37]. High glucose level leads to produce excess ROS that damage the kidney glomeruli leading to albuminuria [38].…”

Section: Discussionmentioning

confidence: 99%

Effect of Curcumin and Angiotensin II Receptor Antagonist on Insulin Sensitivity and on Inflammation in Induced Diabetic Rats

Nassar¹,

Mansour²,

Abd‐Allah³

et al. 2017

J Invest Biochem

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Objective: In this study, we aimed to discuss the effect of curcumin and/or irbesartan on diabetic complications in induced diabetic rats. Materials and Methods: Diabetic rats induced by intraperitoneal injection of 45 mg/kg dose of streptozotocin (STZ) in adult rats. Rats were divided into six groups of 10 rats on each. Serum glucose, creatinine, and urea were estimated using a colorimetric method. Serum insulin and serum and kidney homogenate interleukin 6 (IL-6) were measured using enzyme-linked immunosorbent assay technique. While paraffin-embedded kidney and pancreas specimens were performed for histopathological examination. While homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Results: Curcumin and/or irbesartan reduce the degradation of kidneys and pancreatic tissues as indicated in both histopathology and tissue IL-6. They improve the weight loss and IR. In addition, they lower circulating level of IL-6, serum creatinine, and urea. Diabetic rats received the medications show significantly better insulin and glucose levels as compared to STZ group. Conclusion: Chronic administration of curcumin and/or irbesartan for diabetic rats decreased serum glucose and HOMA-IR and lowered the increased serum levels of pro-inflammatory cytokines. Using such combination could be beneficial in diabetic managements, especially if diabetes accompanied with hypertension.

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“…Diabetes is the leading cause of CKD in most countries (Abboud & Henrich, 2010;Hung et al, 2017;Jha, Wang, & Wang, 2012;Orantes-Navarro et al, 2017). Diabetes causes structural and functional changes in the kidneys, mostly due to glomerulosclerosis (Lim, 2014) that directly increases glomerular permeability and worsening albuminuria (Toth-Manikowski & Atta, 2015). Diabetic nephropathy accounts for about 30% to 45% of ESKD cases worldwide, with 44% in the U.S. (CDC, 2017) and 37% in 2015 in Australia (ANZDATA Registry, 2017).…”

Section: Causesmentioning

confidence: 99%

Self-Management Program for People with Chronic Kidney Disease in Vietnam: A Pragmatic Randomised Controlled Trial

Nguyen¹

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Diabetic nephropathy – complications and treatment

Cited by 517 publications

References 237 publications

Clinical and biochemical aspects associated with diabetic nephropathy among type 2 diabetic males in Gaza strip

Clinical and biochemical aspects associated with diabetic nephropathy among type 2 diabetic males in Gaza strip

Effect of Curcumin and Angiotensin II Receptor Antagonist on Insulin Sensitivity and on Inflammation in Induced Diabetic Rats

Self-Management Program for People with Chronic Kidney Disease in Vietnam: A Pragmatic Randomised Controlled Trial

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