BackgroundPhenotypes can be utilized in the clinical management of disorders. The approaches to phenotype disorders have evolved from subjective expert opinion to data-driven methodologies. A previous cluster analysis among working-age subjects with cough revealed a phenotype TBQ (Triggers, Background disorders, Quality of life impairment), which included 38% of the subjects with cough. The present study was carried out to validate this phenotyping among elderly, retired subjects with cough.MethodsThis was an observational, cross-sectional study conducted via email among the members of the Finnish Pensioners' Federation (N=26 205, 23.6% responded). The analysis included 1109 subjects with current cough (mean age 72.9 (sd 5.3) years) with 67.7% females). All filled in a comprehensive 86-item questionnaire including the Leicester Cough Questionnaire. Phenotypes were identified utilizing K-means partitional clustering.ResultsTwo clusters were identified. The cluster A included 75.2% and cluster B 24.8% of the subjects. The three most important variables to separate the clusters were the number of cough triggers (mean 2.47 (2.34) versus 7.08 (3.16), respectively, p<0.001), Leicester Cough Questionnaire physical domain (5.38 (0.68) versus 4.21 (0.81), respectively, p<0.001), and the number of cough background disorders (0.82 (0.78) versus 1.99 (0.89), respectively, p<0.001).ConclusionThe phenotype TBQ could be identified also among elderly, retired subjects with cough, thus validating the previous phenotyping among working-age subjects. The main underlying pathophysiological feature separating the phenotype TBQ from the common cough phenotype is probably hypersensitivity of the cough reflex arc.