Diagnosing Graves’ Disease and Non-Graves Hyperthyroidism Using TSH Receptor Antibody Test versus Non-TSH Receptor Antibody Test Methods of Diagnosis

Abstract

Background: Differentiating Graves hyperthyroidism from the other causes of hyperthyroidism, using serum TRAb testing is essential step for diagnosis. Objectives: To study importance of TRAb in the diagnosis of Graves' disease, distinguishing it from thyroiditis, and comparing it with clinical features and other tests such as TPOAb, US thyroid and thyroid scintiscan. Methods: A cross-sectional study was conducted on 120 patients attending endocrine cli-nicErbil city. Patients were studied on clinical feature basis and investigated with serum TRAb, TPOAb, TSH, Free T4, and Ultrasound examination of thyroid gland. Fisher exact test and Chi Square test of independence, Correlation coefficient and t-test of independence were used. Results: Fifty-two patients were found to have Graves' disease; There was significant correlation between TRAb positivity and diagnosis of Graves' disease p < 0.05. There was also strong relation between presence of goiter, Orbitopathy and Ultrasound findings and TRAb positivity, p < 0.05. There was statistically significant difference between mean levels of TRAb and fT4 between Graves patients and Thyroiditis groups, while there was no statistically significant difference in TPOAb and TSH means between the two groups, p > 0.05. Conclusion: A positive correlation was found between TRAb titer and positivity and no significant relation between TPOAb levels between Graves' disease patients compared with thyroiditis patients, respectively.

The role of anti-TPO as an additional analytical marker in thyroid disease patients in Erbil City

“…The normal ranges for TSH, T4, and T3 are respectively Range of measurement: 5.00-600 IU/mL (defined by the lower detection limit and the maximum of the master curve). Anti-TPO has a normal range upper limit of >30 IU/ml [15].…”