Diagnosing Non-Small Cell Lung Cancer by Exhaled Breath Profiling Using an Electronic Nose

Kort, Sharina; Brusse-Keizer, Marjolein; Schouwink, Hugo; Citgez, Emanuel; Jongh, Frans de; Putten, John van; Borne, Ben van den; Kastelijn, Lisanne; Stolz, Daiana; Schuurbiers, Milou; Heuvel, Michel van den; Geffen, Wouter H. van; Palen, Job van der

doi:10.1016/j.chest.2022.09.042

Cited by 34 publications

(17 citation statements)

References 44 publications

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“…Wang et al found 16 VOCs in a targeted analysis during perioperative exhaled breath analysis in patients with lung cancer with high-pressure photon ionization time-offlight mass spectrometry and validation confirmed good performance [25]. In a multicenter, multi device study including 575 subjects, Kort et al could distinguish patients lung cancer from lung cancer using an electronic nose, with an area under the receiver-operating characteristic curve of 0.86 [26]. Despite decades of research, variability in sample collection, testing conditions, and data analysis significant challenges among these studies to the widespread adoption exhaled breath analysis in clinical settings.…”

Section: Discussionmentioning

confidence: 97%

Exhaled breath analysis in patients with potentially curative lung cancer undergoing surgery: a longitudinal study

Herth,

Schmidt,

Basler

et al. 2024

J. Breath Res.

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Exhaled breath analysis has emerged as a non-invasive and promising method for early detection of lung cancer, offering a novel approach for diagnosis through the identification of specific biomarkers present in a patient's breath. For this longitudinal study, 29 treatment-naive patients with lung cancer were evaluated before and after surgery. Secondary electrospray ionization high-resolution mass spectrometry was used for exhaled breath analysis. Volatile organic compounds with absolute log2 fold change ≥ 1 and q-values ≥ 0.71 were selected as potentially relevant. Exhaled breath analysis resulted in a total of 3482 features. 515 features showed a substantial difference before and after surgery. The small sample size generated a false positive rate of 0.71, therefore, around 154 of these 515 features were expected to be true changes. Biological identification of the features with the highest consistency (m/z -242.18428 and m/z -117.0539) revealed to potentially be 3-Oxotetradecanoic acid and Indole, respectively. Principal component analysis revealed a primary cluster of patients with a recurrent lung cancer, which remained undetected in the initial diagnostic and surgical procedures. The change of exhaled breath patterns after surgery in lung cancer emphasizes the potential for lung cancer screening and detection.

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Section: Discussionmentioning

confidence: 97%

Exhaled breath analysis in patients with potentially curative lung cancer undergoing surgery: a longitudinal study

Herth,

Schmidt,

Basler

et al. 2024

J. Breath Res.

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show abstract

“…These volatile organic compounds, in certain concentrations and combinations, create a breath fingerprint that could be used to diagnose cancer. The results obtained show a sensitivity of the test of 95%, a specificity of 51% and a negative predictive value of 94% [16]. Also, studies are still ongoing for its use in the diagnosis of colorectal cancer, tuberculosis or other respiratory infections.…”

Section: Screeningmentioning

confidence: 90%

“…In some countries these registers also collect information on workers at risk of exposure and can identify areas of increased risk of exposure where prevention measures can be initiated. Some of these registers are The Finnish Register of Workers Exposed to Carcinogens (ASA Register), the Italian Information System for Recording Occupational Exposures to Carcinogens (SIREP) and the German ODIN Register [16]. In Italy and Germany, there are parallel registers of cancers caused by exposure to asbestos -the National Mesothelioma Registry and the Register of asbestos-exposed workers (GVS).…”

Section: Exposure Registriesmentioning

confidence: 99%

Patterns in medical surveillance of workers exposed to lung carcinogens

Mandanach

2023

Romanian Journal of Occupational Medicine

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One of the most common causes of lung cancer is exposure to occupational carcinogens. Free silica, diesel exhaust fumes, dyes, radon and with asbestos at the top of the list, differ by percentage according to the predominant professional activities in each country. The occupational health doctor is directly involved in the surveillance of the exposed worker, during work or post exposure, in the diagnosis and reporting of occupational cancers. Efficient screening followed by reporting and monitoring cases of occupational lung cancer and, last but not least, reintegration into professional activity are important steps in the medical surveillance of the worker exposed to occupational lung carcinogens. Standardised information collected at the level of occupational exposure monitoring systems, separated by carcinogen category and profession, may form the basis of control and prevention plans. Harmonising medical surveillance at European and global level can lead to a decrease in the incidence and mortality of work-related lung cancer.

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“…Another study by Kort and her colleagues have shown that non-small cell LC (NSCLC) could be differentiated from suspected LC by using different electronic nose device-Aeonose which had a better sensitivity (94.4%) but lower specificity (32.9%) [18]. Recently, the same authors have published a multicenter validation study concluding that by combining exhaled breath data with clinical variables, they could discriminate between NSCLC from non cancer subjects [19]. Marzorati and colleagues have developed an artificial neural networkbased classification tool which could discriminate healthy controls from LC with a sensitivity of 85.7%, specificity of 100%, and accuracy of 93.8% [20].…”

Section: Diagnosis Of Lc Using Enosementioning

confidence: 99%

A review on electronic nose for diagnosis and monitoring treatment response in lung cancer

et al. 2023

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Lung cancer is one of the common malignancies with high mortality rate and a poor prognosis. Most lung cancer cases are diagnosed at an advanced stage either due to limited resources of infrastructure, trained human resources, or delay in clinical suspicion. Low-dose computed tomography (LDCT) has emerged as a screening tool for early lung cancer detection but may not be a feasible option for most developing countries. Electronic nose (eNOSE) is a unique non-invasive device that has been developed for lung cancer diagnosis and monitoring response by exhaled breath analysis of volatile organic compounds (VOCs). The breath-print have been shown to differ not only among lung cancer and other respiratory diseases, but also between various types of lung cancer. Hence, we postulate that the breath-print analysis by electronic nose could be a potential biomarker for the early detection of lung cancer along with monitoring treatment response in a resource-limited setting. In this review, we have consolidated the current published literature suggesting the use of an electronic nose in the diagnosis and monitoring treatment response of lung cancer.

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Diagnosing Non-Small Cell Lung Cancer by Exhaled Breath Profiling Using an Electronic Nose

Cited by 34 publications

References 44 publications

Exhaled breath analysis in patients with potentially curative lung cancer undergoing surgery: a longitudinal study

Exhaled breath analysis in patients with potentially curative lung cancer undergoing surgery: a longitudinal study

Patterns in medical surveillance of workers exposed to lung carcinogens

A review on electronic nose for diagnosis and monitoring treatment response in lung cancer

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