Diagnosis and management of endometriosis

Allaire, Catherine; Yong, Paul J.

doi:10.1503/cmaj.220637

Cited by 87 publications

(35 citation statements)

References 58 publications

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“…Despite the increasing body of evidence demonstrating similarities between EAP and other chronic pain conditions, relatively few studies have considered these types of therapies either alone or as a component of a multidisciplinary pain management programme. This is disappointing given that there is evidence of benefit in chronic pelvic pain more generally [1,32].…”

Section: Multidisciplinary Carementioning

confidence: 99%

“…Endometriosis is defined as the presence of tissue resembling the endometrium outside of the uterus and affects one in 10 women of reproductive age, and an unknown number of trans-men, nonbinary and sex diverse people [1]. It is important to be aware that symptoms often start in adolescence and may not stop after reproductive age, continuing beyond the menopause for some.…”

Section: Introductionmentioning

confidence: 99%

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Endometriosis – a painful disease

Coxon,

Evans,

Vincent

2023

Current Opinion in Anaesthesiology

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Purpose of review This review looks to overview advances in endometriosis-associated pain, both in understanding the pain mechanisms involved and increasing treatment options with well designed clinical trials and meta-analyses. Recent findings Our understanding of endometriosis-associated pain has progressed from a purely nociceptive model to an awareness that both neuropathic and nociplastic mechanisms can be present for some people with endometriosis. Clinical trials and meta-analyses have demonstrated efficacy of surgical treatments and hormonal therapies. It is notable that currently, the basic science and clinical trials are not cross-fertilising. Summary Following growth in other areas of chronic pain, there have been significant advances in our understanding of endometriosis-associated pain. However, there remains lots to explore and we are currently a long way from our goal of timely personalized holistic multidisciplinary treatment for all sufferers of endometriosis-associated pain.

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Section: Multidisciplinary Carementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endometriosis – a painful disease

Coxon,

Evans,

Vincent

2023

Current Opinion in Anaesthesiology

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“…Endometriosis affects more than 176 million women globally (3). Pelvic endometriosis is primarily classi ed as super cial peritoneal endometriosis, deep endometriosis, and ovarian endometrioma (4). Despite the high prevalence of endometriosis, diagnosing the condition remains challenging, with 65% of women being initially misdiagnosed (5).…”

Section: Introductionmentioning

confidence: 99%

Global, regional, and national prevalence and disability-adjusted life-years for endometriosis in 204 countries and territories, 1990– 2019: findings from a global burden of disease study

Shen,

Li,

et al. 2024

Preprint

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Introduction: This study aimed to analyze the worldwide, regional, and intra-country burden of heteropathy and its trends from 1990 to 2019, utilizing the latest data and improved methodologies from GBD 2019. Methods: We utilized the Global Health Data Exchange Query tool, Global Burden of Disease (GBD), to analyze endometriosis in prevalence numbers, age-standardized prevalence rates (ASPR), and disability-adjusted life-years (DALYs) from 1990 to 2019 in 204 countries and regions. Additionally, this study investigated the impacts of period, age, and cohort on the prevalence and DALYs of endometriosis from the global perspective and in the five sociodemographic index (SDI) regions. Results: Among the 21 regions, the most significant reduction in the prevalence of heterosis between 1990 and 2019 occurred in Central Latin America. In 204 countries, the most pronounced decline was observed in Guatemala. At the SDI level, with the increase of SDI, the ASPR of endometriosis in all regions worldwide showed an overall decreasing trend. The prevalence of endometriosis peaked between the ages of 25 and 29. Discussion: The findings of this study reflect the temporal and spatial tendency of the burden of endometriosis during the study period and provide an epidemiological basis for reducing endometriosis.

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“…Epidemiological studies have helped quantify the socioeconomic impact and quality of life of women affected by endometriosis [2][3][4][5][6][7][8]. This research has revealed not only the substantial financial burden associated with endometriosis but also highlighted the importance of holistic approaches that consider not only medical aspects but also the social and psychological impacts of this condition.…”

Section: Introductionmentioning

confidence: 99%

What Is Behind? Impact of Pelvic Pain on Perceived Stress and Inflammatory Markers in Women with Deep Endometriosis

Osaki,

Oliveira

2024

JCM

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Introduction/Objectives: Endometriosis affects 10% of women worldwide. It is noteworthy that this condition is often accompanied by pelvic pain and stress. Endometriosis is a debilitating gynecological condition where tissue similar to the uterine lining grows outside the uterus, often causing significant pain and reproductive issues. We aimed to study the relationship between the intensity of pelvic pain, and stress and inflammatory markers in women with deep endometriosis. Methods: This cross-sectional study analyzed women diagnosed with deep endometriosis through imaging, surgery, and/or biopsy. We assessed pain using the Numerical Rating Scale (NRS). Stress was assessed with the Perceived Stress Scale (PSS-10) questionnaire and the serum cortisol levels. Additionally, we analyzed inflammatory markers, including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Results: Fifty-two women, with an average age of 37.8 ± 6.9 years, participated in this study. Forty-four percent of these participants demonstrated high levels of stress, as indicated by scores above 26 on the PSS-10. Those categorized with “high stress” on the PSS-10 questionnaire exhibited significantly higher pain levels compared to those with “low stress” (p < 0.05). Furthermore, patients experiencing more-severe pelvic pain (pain score > 7) had notably higher serum cortisol levels. Women with intense pelvic pain (scores above 7 on the NRS) had significantly elevated serum cortisol levels (Cohen’s d = 0.72; p = 0.018). Conclusions: A positive association was found between stress levels and the intensity of pelvic pain in women with deep endometriosis, suggesting an interconnection between emotional aspects and biological responses.

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Diagnosis and management of endometriosis

Abstract: Endometriosis is a common disorder that can cause pelvic pain and infertility, may involve multiple organ systems and can adversely affect quality of life.

Cited by 87 publications

References 58 publications

Endometriosis – a painful disease

Endometriosis – a painful disease

Global, regional, and national prevalence and disability-adjusted life-years for endometriosis in 204 countries and territories, 1990– 2019: findings from a global burden of disease study

What Is Behind? Impact of Pelvic Pain on Perceived Stress and Inflammatory Markers in Women with Deep Endometriosis

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