Diagnosis and treatment of 409 patients with prostatitis syndromes

Rosette, Jean J.M.C.H. de la; Hubregtse, M.; Meuleman, E.J.H.; Stolk-Engelaar, M.V.M.; Debruyne, F.M.J.

doi:10.1016/0090-4295(93)90584-w

Cited by 178 publications

(76 citation statements)

References 17 publications

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“…There can be little debate concerning the treatment of CBP where a 'typical' pathogen is isolated from the site of infection. However, the recommendation for antibiotic therapy in culture-negative cases (chronic inflammatory prostatitis) and cases where an 'atypical' organism is isolated, is contrary to that suggested by some authors [11,20].…”

Section: Patients Recommended For Antibiotic Therapycontrasting

confidence: 39%

“…A negative culture result may arise as a consequence of sampling errors, or poor culture or detection techniques [20]. This recommendation is supported by clinical evidence showing that culture-negative cases of chronic prostatitis do respond to antibiotic treatment [11,21]. If there is clinical and immunological evidence of infection, we consider that antibiotic therapy should be tried in culture-negative cases.…”

Section: Patients Recommended For Antibiotic Therapymentioning

confidence: 82%

“…In the majority of patients, bacteriological evaluation of prostatic fluid either fails to identify a pathogen or identifies an organism of debatable significance, for example, Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis, even though in many of these patients (60%) significant prostatic inflammation can be demonstrated (leucocyte counts in EPS of 110/hpf or 11,000/Ìl) [7,11].…”

Section: Prostatodyniamentioning

confidence: 99%

“…It is also impossible to make a diagnosis by examining the EPS in isolation due to unavoidable contamination from the urethra [9]. Thirdly, the most accurate test currently available for the differential diagnosis of chronic prostatitis, the Meares and Stamey localization technique [10], is rarely used by clinicians because it has low sensitivity, its interpretation criteria are, as yet, not unambiguously defined, it is timeconsuming, relatively expensive, and patient-invasive [6,7,11,12]. However, despite these shortcomings, it remains a fundamental diagnostic tool in clinical trials of chronic prostatitis.…”

Section: Prostatodyniamentioning

confidence: 99%

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The Role of Antibiotics in the Treatment of Chronic Prostatitis: A Consensus Statement

Johansen¹,

Grüneberg²,

Guibert³

et al. 1999

Journal of Urology

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Practical guidelines for the diagnosis and treatment of chronic prostatitis are presented. Chronic prostatitis is classified as chronic bacterial prostatitis (culture-positive) and chronic inflammatory prostatitis (culture-negative). If chronic bacterial prostatitis is suspected, based on relevant symptoms or recurrent UTIs, underlying urological conditions should be excluded by the following tests: rectal examination, midstream urine culture and residual urine. The diagnosis should be confirmed by the Meares and Stamey technique. Antibiotic therapy is recommended for acute exacerbations of chronic prostatitis, chronic bacterial prostatitis and chronic inflammatory prostatitis, if there is clinical, bacteriological or supporting immunological evidence of prostate infection. Unless a patient presents with fever, antibiotic treatment should not be initiated immediately except in cases of acute prostatitis or acute episodes in a patient with chronic bacterial prostatitis. The work-up, with the appropriate investigations should be done first, within a reasonable time period which, preferably, should not be longer than 1 week. During this period, nonspecific treatment, such as appropriate analgesia to relieve symptoms, should be given. The minimum duration of antibiotic treatment should be 2-4 weeks. If there is no improvement in symptoms, treatment should be stopped and reconsidered. However, if there is improvement, it should be continued for at least a further 2-4 weeks to achieve clinical cure and, hopefully, eradication of the causative pathogen. Antibiotic treatment should not be given for 6-8 weeks without an appraisal of its effectiveness. Currently used antibiotics are reviewed. Of these, the fluoroquinolones ofloxacin and ciprofloxacin are recommended because of their favourable antibacterial spectrum and pharmacokinetic profile. A number of clinical trials are recommended and a standard study design is proposed to help resolve some outstanding issues.

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Section: Patients Recommended For Antibiotic Therapycontrasting

confidence: 39%

Section: Patients Recommended For Antibiotic Therapymentioning

confidence: 82%

Section: Prostatodyniamentioning

confidence: 99%

Section: Prostatodyniamentioning

confidence: 99%

See 2 more Smart Citations

The Role of Antibiotics in the Treatment of Chronic Prostatitis: A Consensus Statement

Johansen¹,

Grüneberg²,

Guibert³

et al. 1999

Journal of Urology

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“…1 Initial studies have estimated that up to 50% of men at some point in their life may suffer from prostate inflammation. 2 More recent studies have recorded incidences of prostatitis ranging from 3 to 16% in North America, Europe and Asia 1,3-9 half of whom will have repeat episodes 10 emphasizing that prostatitis is an important worldwide health problem. Unlike benign prostate hyperplasia and prostate cancer, prostatitis affects adult men of all ages and is generally considered to be the most common outpatient condition seen in urologic practice in men younger than 50 years old.…”

Section: Introductionmentioning

confidence: 99%

Experimental rodent models of prostatitis: limitations and potential

Vykhovanets

Resnick

MacLennan

et al. 2007

Prostate Cancer Prostatic Dis

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Prostatitis is a polyetiological inflammation of the prostate gland in men characterized by pelvic pain, irritative voiding symptoms, and sexual dysfunction. Histologically prostatitis is characterized by poly-and mononuclear cell infiltrates (neutrophils, lymphocytes, macrophages and plasma cells) in the stromal connective tissue around the acini or ducts. Prostatitis is an important worldwide health problem in men. The pathogenesis and diagnostic criteria for the condition are obscure, with the result that the development of management programs for this condition has been hindered. Animal model(s) might be useful in elucidating mechanisms involved in the molecular pathogenesis of chronic nonbacterial prostatitis and chronic pelvic pain syndrome. Given that prostatitis might have a multifactorial etiology, several animal models with unique features may prove helpful. This review examines a number of experimental rodent models of prostatitis and evaluates their advantages and limitations.

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Management of Chronic Prostatitis/ Chronic Pelvic Pain Syndrome

Anothaisintawee

Attia²,

Nickel³

et al. 2011

JAMA

239

151

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Context Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is common, but trial evidence is conflicting and therapeutic options are controversial.Objective To conduct a systematic review and network meta-analysis comparing mean symptom scores and treatment response among α-blockers, antibiotics, anti-inflammatory drugs, other active drugs (phytotherapy, glycosaminoglycans, finasteride, and neuromodulators), and placebo.

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Diagnosis and treatment of 409 patients with prostatitis syndromes

Cited by 178 publications

References 17 publications

The Role of Antibiotics in the Treatment of Chronic Prostatitis: A Consensus Statement

The Role of Antibiotics in the Treatment of Chronic Prostatitis: A Consensus Statement

Experimental rodent models of prostatitis: limitations and potential

Management of Chronic Prostatitis/ Chronic Pelvic Pain Syndrome

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