Diagnosis and treatment of premalignant lesions of the vulva: A review

Underwood, Paul B.; Hester, Lawrence L.

doi:10.1016/0002-9378(71)90582-5

Cited by 16 publications

(1 citation statement)

References 6 publications

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“…This patient also suffered from prolonged and intractable pruritus vulvae, resulting in widespread excoriations. Chronic irritation is a well recognized synergistic factor in carcinogenesis (Underwood & Hester, 1971). The recent characterization in skin cancers of new types of HPV having a low degree of similarity with HPV16 by Scheurlen et al (1985) and Ostrow et al (1985) suggests that it would be worth including this and other probes in low stringency screening.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus infections in a group of renal transplant recipients

et al. 1986

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One hundred and twenty renal transplant recipients were investigated. Fifty-eight (48%) were found to have warts, 13 (11%) keratoses and six (5%) to have, or recently to have had cancers. The longer the time of immunosuppression, the greater the prevalence of warts; of those patients who had had their transplant for at least 5 years, 87% had warts. Those with a graft survival time of 10 years or more are at special risk of warts, keratoses and malignancy. Five (10%) of 50 women had genital warts, four of whom had internal lesions (vaginal, cervical or anal) and one developed a carcinoma of the vulva. These findings indicate the advisability of colposcopy for all female renal transplant recipients, a high risk group. Eighty-eight specimens from 42 patients were examined by DNA restriction enzyme analysis and cross hybridization for the presence and type of human papillomavirus (HPV). HPV DNA was detected in 66% of the warts examined, HPV2 and HPV4 occurring most often and HPV1 and HPV3 only infrequently. In sequential specimens from common hand warts of one individual, an HPV was found which could not be precisely identified but was related to HPV4. HPV16 was detected in a vaginal wart from one patient and an HPV6-related virus in a vulval wart of another. HPV DNA of an unknown type was demonstrated in one of 11 keratoses examined. With the probes used to examine the few samples of skin cancers available, HPV16 was found in a squamous cell carcinoma of the vulva, and faint bands from an unidentified type of HPV were detected in two squamous cell carcinomata from a patient's hand. One woman had plaque lesions morphologically and histologically resembling those found in epidermodysplasia verruciformis (EV). HPV5 was identified in these lesions. This is only the third reported case of HPV5, previously thought to be unique to EV, in a renal transplant recipient.

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Section: Discussionmentioning

confidence: 99%

Human papillomavirus infections in a group of renal transplant recipients

et al. 1986

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Viruses and cancer of the lower genital tract

Josey¹,

Nahmias²,

Naib³

1976

Cancer

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The importance of viruses as oncogenic agents in animals is well established. Recent work suggests that viruses may also be etiologically related to some human cancers. Herpes simplex virus type 2 (HSV‐2) and the genital wart virus are prime suspects in carcinomas involving the female lower genital tract. In particular, a close association has been found between HSV‐2 infection and cervical neoplasia in cytohistopathologic and seroepidemiologic studies. Preliminary results of prospective studies show further that women with genital herpetic infection are at increased risk of developing cervical neoplasia. Additional studies are also in progress on animal models, including subhuman primates, and efforts continue in the attempt to confirm the presence of viral genetic material or its expression in human cervical cancer cells. The possibility that human wart viruses have an oncogenic potential is suggested by clinicopathologic and electron microscopic observations. Further research is needed to ascertain the precise role of viruses in genital cancer.

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Variation in the appearance of giant condyloma in an Ugandan series of cases of carcinoma of the penis

Schmauz

Findlay

Lalwak

et al. 1977

Cancer

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Whole mount sections were made from all amputation specimen of patients treated for carcinoma of the penis in Mulago Hospital, Kampala, Uganda, during a 21-month period in 1968-1970. Among a total of 55 cases four tumors were found which were large, but histologically showed low invasiveness suggestive of absence of metastatic spread. There were two giant condylomas, and two giant condylomas showing possible microinvasion. Two further cases showed a small squamous cell carcinoma together with a giant condyloma in the remainder of tumor. The most chracteristic feature was an orderly, well-circumscribed, expansive downgrowth, leaving little stroma to be seen between the epithelial masses to tumor. Within these limits, however, the spectrum of growth pattern, differentiation, and malignant change was very wide and much more varied than in tumors recorded form Western countries. This should be remembered when a presumptive diagnosis of the condition is to be made on small routine biopsies. Additional changes showing marked similarities to condylomata acuminata were often seen in superficial portions of tumor. This transition in histological picture within one tumor favors the view that giant condyloma is an intermediate lesion in the development of cancer in condylomata acuminata.

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Diagnosis and treatment of premalignant lesions of the vulva: A review

Cited by 16 publications

References 6 publications

Human papillomavirus infections in a group of renal transplant recipients

Human papillomavirus infections in a group of renal transplant recipients

Viruses and cancer of the lower genital tract

Variation in the appearance of giant condyloma in an Ugandan series of cases of carcinoma of the penis

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