Diagnosis at a Glance (Questions and Answer)

Akimoto, Tetsu; Ito, Chiharu; Nagata, Daisuke

doi:10.2169/naika.103.1991

Cited by 1 publication

(1 citation statement)

References 3 publications

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“…It utilizes the synergistic effects of ultrasound and chemicals that behave as sonodynamic sensitizers (SDS). 1) Ultrasound can enhance the biological effect of some chemicals 2,3) and can even activate SDS through the collapse of cavitation bubbles. 4) The thermal bioeffect of ultrasound alone has already been used clinically for treating tumors with high-intensity focused ultrasound treatment.…”

Section: Introductionmentioning

confidence: 99%

Sonodynamically-induced cytotoxicity by rose bengal derivative and microbubbles in isolated sarcoma 180 cells

Sugita

Hosokawa

Sunaga

et al. 2015

Jpn. J. Appl. Phys.

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It is known that the combination of ultrasound and sonodynamic sensitizer (SDS) is effective in noninvasive tumor treatment, referred to as sonodynamic therapy (SDT). Microbubbles have been used in ultrasound therapy as well. The purpose of this paper is to clarify the effect of microbubbles on SDT. Sarcoma 180 cells were suspended in air-saturated phosphate-buffered saline and exposed to ultrasound with the SDS rose bengal derivative (RBD) in standing wave mode in the presence and absence of microbubbles [sonazoid (SZ)]. The ultrasonically induced cytotoxicity with RBD and SZ was about 20 times higher than without either, and about 80% of the SZ microbubbles were destructed by ultrasonic exposure in as short as five seconds. Since microbubbles induce significant cytotoxicity even with short duration, low intensity ultrasound, the application of microbubbles in SDT shows promise in anti-tumor treatment.

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