Diagnosis: History, Physical Examination, Imaging, and Arthroscopy: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle

Bergen, Christiaan J. A. van; Baur, O; Murawski, Christopher D.; Spennacchio, Pietro; Carreira, Dominic S.; Kearns, Stephen; Mitchell, Adam; Pereira, Hélder; Pearce, Christopher J.; Calder, James; Ackermann, Jakob; Adams, Samuel B.; Andrews, Carol L.; Angthong, Chayanin; Batista, Jorge; Bayer, Steve; Becher, Christoph; Berlet, Gregory C.; Boakye, Lorraine; Brown, Alexandra J.; Buda, Roberto; Canata, Gian Luigi; Clanton, Thomas O.; Dahmen, Jari; D’Hooghe, Pieter; DiGiovanni, Christopher W.; Dombrowski, Malcolm E.; Drakos, Mark C.; Ferkel, Richard D.; Ferrao, Paulo N. F.; Fortier, Lisa A.; Glazebrook, Mark; Giza, Eric; Gomaa, Mohamed; Görtz, Simon; Haleem, Amgad M.; Hamid, Kamran S.; Hangody, László; Hannon, Charles P.; Haverkamp, Daniël; Hertel, Jay; Hintermann, Beat; Hogan, MaCalus V.; Hunt, Kenneth J.; Hurley, Eoghan T.; Karlsson, Jón; Kennedy, John G.; Kerkhoffs, Gino M. M. J.; Kim, Soo Hyun; Kong, Siu Wah; Labib, Sameh A.; Lambers, Kaj T. A.; Lee, Jin Woo; Lee, Keun Bae; Ling, Jeffrey S.; Longo, Umile Giuseppe; Marangon, Alberto; McCollum, Graham; Mittwede, Peter N.; Nehrer, Stefan; Niemeyer, Philipp; Nunley, James A.; O’Malley, Martin J.; Osei-Hwedieh, David O.; Paul, Jochen; Popchak, Adam; Prado, Marcelo Pires; Raikin, Steven M.; Reilingh, Mikel L.; Rothrauff, Benjamin B.; Schon, Lew C.; Shimozono, Yoshiharu; Simpson, Helene; Smyth, Niall A.; Sofka, Carolyn M.; Stone, James W.; Sullivan, Martin; Takao, Masato; Tanaka, Yasuhito; Thordarson, David B.; Tuan, Rocky S.; Valderrábano, Víctor; Dijk, C. Niek van; Dijk, Pim A. D. van; Vannini, Francesca; Vaseenon, Tanawat; Walther, Markus; Wiewiorski, Martin; Xu, Xiangyang; Yasui, Youichi; Hua, Yinghui; Yoshimura, Ichiro; Younger, Alastair; Zhang, Zijun

doi:10.1177/1071100718779393

Cited by 22 publications

(21 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have used the 9-grid scheme to determine the prevalence of different OLT locations, and there is strong consensus among the orthopedic community for this grid scheme. 6,18,26 Our study further supports the literature that kappa values can be used in the orthopedic and radiology communities to validate radiographic analysis of different osseous or cartilaginous lesions in the extremities. 3,5,9 Furthermore, many studies have found MRI accurate and superior to other imaging studies when diagnosing OLTs as this imaging modality is better at evaluating the overlying cartilage.…”

Section: Discussionsupporting

confidence: 82%

“…This method is gaining popularity with surgeons from the International Consensus Meeting on Cartilage Repair of the Ankle, stating there was a strong consensus for its utility within the orthopedic community. 26 Furthermore, it has been used in both basic science and clinical research. 12,18 However, there has been no study to evaluate its validity within the literature.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Validation of 9-Grid Scheme for Localizing Osteochondral Lesions of the Talus

Martin

McBride

Horan

et al. 2020

Foot & Ankle Orthopaedics

View full text Add to dashboard Cite

Background: A 9-grid scheme has been integrated into the foot and ankle literature to help clinicians and researchers localize osteochondral lesions of the talus (OLTs). We hypothesized that fellowship-trained orthopedic foot and ankle surgeons would have a high rate of intra/inter-observer reliability when localizing OLTs, therefore validating the scheme. Methods: We queried our institution’s foot and ankle radiographic database for magnetic resonance images with OLTs. Each MRI was reviewed by the senior author, and 2 key images (widest OLT diameter) from each tangential view were copied and combined onto one slide. Fifty consecutive deidentified images of ankles were then sent to 4 practicing fellowship-trained foot and ankle surgeons. Each was asked to identify which zone the OLT was localized within. A radiologist’s report served as the control. Statistical analyses were performed using Cohen and Fleiss kappa tests. Results: The reviewers demonstrated majority consensus on 45/50 images with substantial agreement for zones 4 and 6. The interobserver reliability was moderate with a κ = 0.55. The mean intraobserver reliability was substantial, with a κ = 0.79. A musculoskeletal radiologist determined there were 3 lesions in zone 7, 18 lesions in zone 4, and 29 lesions in zone 6. Conclusion: This study is the first to critically evaluate the 9-grid scheme and its reliability among orthopedic foot and ankle surgeons. Our study found that the 9-grid scheme is an accurate method of localization for OLTs with high intra- and moderate interobserver reliability between surgeons. Level of Evidence: Level IV, retrospective diagnostic study.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Validation of 9-Grid Scheme for Localizing Osteochondral Lesions of the Talus

Martin

McBride

Horan

et al. 2020

Foot & Ankle Orthopaedics

View full text Add to dashboard Cite

show abstract

“…Up to date, there is no consensus in the literature with regard to optimal images and tests to request in patients with suspected ankle cartilage injury, as well as with regard to specific imaging protocols that should be used. Furthermore, no study has examined the relationship between the results of preoperative imaging scans and operative findings (5) .…”

Section: Discussionmentioning

confidence: 99%

New classification of osteochondral lesions of the talus in adults

Batista¹,

Joannas²,

Casola³

et al. 2021

J Foot Ankle

View full text Add to dashboard Cite

Osteochondral lesions (OCL) of the ankle in adults are frequent lesions that mainly affect the cartilage and the subchondral bone, are relatively common, and have varied etiologies. However, in 50% of patients, these lesions may occur concomitantly with chronic instability of the ankle associated with lower limb deformities, acute sprains of the ankle, or fractures. We propose a classification into four types of lesions (traumatic, non-traumatic, with lateral instability of the ankle, and with mechanical axis defects), focusing not only on the diagnosis and treatment of OCL but also on associated injuries, such as instability and/or supramalleolar and hindfoot deformities. Level of Evidence V; Therapeutic Studies; Expert Opinion.

show abstract

“…Cartilage injuries were confirmed by preoperative MRI, arthroscopic examinations and intraoperative measurement; outerbridge grading was performed by senior surgeons 43 44. Synovial fluid was aspirated during surgery and sent for laboratory examination.…”

Section: Methodsmentioning

confidence: 99%

Type II collagen facilitates gouty arthritis by regulating MSU crystallisation and inflammatory cell recruitment

Zhang

Chen

et al. 2022

Ann Rheum Dis

View full text Add to dashboard Cite

ObjectiveIncreasing evidence suggests that impaired cartilage is a substantial risk factor for the progression from hyperuricaemia to gout. Since the relationship between cartilage matrix protein and gout flares remains unclear, we investigated its role in monosodium urate (MSU) crystallisation and following inflammation.MethodsBriefly, we screened for cartilage matrix in synovial fluid from gouty arthritis patients with cartilage injuries. After identifying a correlation between crystals and matrix molecules, we conducted image analysis and classification of crystal phenotypes according to their morphology. We then evaluated the differences between the cartilage matrix protein-MSU complex and the pure MSU crystal in their interaction with immune cells and identified the related signalling pathway.ResultsType II collagen (CII) was found to be enriched around MSU crystals in synovial fluid after cartilage injury. Imaging analysis revealed that CII regulated the morphology of single crystals and the alignment of crystal bows in the co-crystalline system, leading to greater phagocytosis and oxidative stress in macrophages. Furthermore, CII upregulated MSU-induced chemokine and proinflammatory cytokine expression in macrophages, thereby promoting the recruitment of leucocytes. Mechanistically, CII enhanced MSU-mediated inflammation by activating the integrin β1(ITGB1)-dependent TLR2/4-NF-κB signal pathway.ConclusionOur study demonstrates that the release of CII and protein-crystal adsorption modifies the crystal profile and promotes the early immune response in MSU-mediated inflammation. These findings open up a new path for understanding the relationship between cartilage injuries and the early immune response in gout flares.

show abstract

Diagnosis: History, Physical Examination, Imaging, and Arthroscopy: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle

Abstract: This international consensus derived from leaders in the field will assist clinicians in the diagnosis of cartilage injuries of the ankle.

Cited by 22 publications

References 16 publications

Validation of 9-Grid Scheme for Localizing Osteochondral Lesions of the Talus

Validation of 9-Grid Scheme for Localizing Osteochondral Lesions of the Talus

New classification of osteochondral lesions of the talus in adults

Type II collagen facilitates gouty arthritis by regulating MSU crystallisation and inflammatory cell recruitment

Contact Info

Product

Resources

About