Diagnosis, management and follow-up of pregnant women with Zika virus infection: A preliminary report of the ZIKERNCOL cohort study on Sincelejo, Colombia

Villamil-Gómez, Wilmer E.; Mendoza-Guete, Anibal; Villalobos, E Rodríguez; González-Arismendy, Edgardo; Uribe-García, Ana María; Castellanos, Jaime E.; Rodríguez‐Morales, Alfonso J.

doi:10.1016/j.tmaid.2016.02.004

Cited by 28 publications

(39 citation statements)

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“…The range of symptoms and signs in pregnancy is similar to that in non-pregnant adults, (10,26,27) and is equally mild, nonspecific and self-limiting, (28)(29)(30)(31) lasting for a similar duration of 4-6 days. (18) Of note, fever is not a predominant feature of ZIKV infection in symptomatic pregnancies, being present in only 28%-46%; (28)(29)(30) even then, most fevers are very low grade (< 38°C).…”

Section: Is the Clinical Course Of Zikv Infection Different In Pregnamentioning

confidence: 81%

“…(18) Of note, fever is not a predominant feature of ZIKV infection in symptomatic pregnancies, being present in only 28%-46%; (28)(29)(30) even then, most fevers are very low grade (< 38°C). A maculopapular rash (sometimes pruritic) was the most common symptom affecting 44%-93% of cases, followed by conjunctivitis (36%-58%), myalgia/arthralgia (39%-64%), headache (53%-62%) and lymphadenopathy (about 40%).…”

Section: Is the Clinical Course Of Zikv Infection Different In Pregnamentioning

confidence: 99%

“…A maculopapular rash (sometimes pruritic) was the most common symptom affecting 44%-93% of cases, followed by conjunctivitis (36%-58%), myalgia/arthralgia (39%-64%), headache (53%-62%) and lymphadenopathy (about 40%). (18,21,28,30) During pregnancy, there does not appear to be an increased risk of developing the rarer complications of myelitis and GBS, (32,33) with only one single case of GBS reported in pregnancy so far. (34) …”

Section: Is the Clinical Course Of Zikv Infection Different In Pregnamentioning

confidence: 99%

“…(50) Retrospective Brazilian case series of infants with features of presumed CZS suggest a high symptomatic rate in 70%-80% of mothers during pregnancy. (28,29,31) This should be cautiously interpreted, as ascertainment bias is inherent in such data, which relies on subject recall following an adverse event and thus tends to overestimate symptomatology rates. Conversely, a recent report from Columbia found that, so far, all four microcephaly cases (HC less than −3 SD) that tested positive for ZIKV in the neonate occurred in mothers who were asymptomatic during pregnancy.…”

Section: Czs and Risk Of Vertical Transmissionmentioning

confidence: 99%

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A review of Zika virus infections in pregnancy and implications for antenatal care in Singapore

Lin

Tambyah

Yong

et al. 2017

smedj

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Given the consensus that there is a causal relationship between Zika virus (ZIKV) infection in pregnancy and congenital Zika syndrome (CZS), clinicians must be prepared to manage affected patients despite the numerous gaps in current knowledge. The clinical course in pregnancy appears similar to that in non-pregnant women, although viraemia may be prolonged. ZIKV infection can be diagnosed by serum and urine reverse transcription-polymerase chain reaction, but commercially available serological tests are currently unreliable in dengue-endemic regions. Although vertical transmission can occur at any time during gestation, first-and second-trimester infections have the highest risk of developing central nervous system anomalies. Aberrant fetal growth and pregnancy loss may also occur. Serial ultrasonography should be conducted for infected cases. Without a vaccine, pregnant women should be advised to minimise mosquito bites and reduce sexual transmission risk. Overall, the absolute risk of CZS arising amid a ZIKV outbreak appears relatively low.

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Section: Is the Clinical Course Of Zikv Infection Different In Pregnamentioning

confidence: 81%

Section: Is the Clinical Course Of Zikv Infection Different In Pregnamentioning

confidence: 99%

Section: Is the Clinical Course Of Zikv Infection Different In Pregnamentioning

confidence: 99%

Section: Czs and Risk Of Vertical Transmissionmentioning

confidence: 99%

See 2 more Smart Citations

A review of Zika virus infections in pregnancy and implications for antenatal care in Singapore

Lin

Tambyah

Yong

et al. 2017

smedj

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“…Particularly, detailed evaluation of morbidity among pregnant women and its mapping due to this arbovirus should be performed, given the potential negative outcomes in terms of the Zika congenital syndrome, including central nervous systems birth defects [11,12]. There is an enhanced number of ZIKV-associated neurological syndromes with 25 cases reported from Valle del Cauca as well one case of acute flaccid paralysis with history of ZIKV infection [10].…”

Section: Discussionmentioning

confidence: 99%

Mapping Zika virus disease incidence in Valle del Cauca

et al. 2016

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used was Kosmo Desktop 3.0RC1 ® . Three thematic incidence rate maps were developed. Results Up to April 2, 2016, 9,825 cases of ZIKV were reported (15.15 % of the country cases). The burden of ZIKV infection has been concentrated in the North of the department. Valle del Cauca borders with other departments with incidence of ZIKV infection, such as Quindío (173 cases) and Risaralda (687 cases). Eleven municipalities of Valle del Cauca had cases in the range between 250 and 499 cases/100,000, all in the North and East of the department. Cali, the capital concentrates more than a third of the reported cases of ZIKV in Valle del Cauca. Conclusions Use of GIS-based epidemiological maps allows to guide decision-making for prevention and control of diseases that constitute significant public health problems in the region and the country, such as exemplified by the emergence of ZIKV infection, particularly in departments such as Valle del Cauca with a high disease incidence.

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