Diagnosis, Management, and Treatment of Chronic Chagas' Heart Disease in Areas Where Trypanosoma cruzi Infection Is Not Endemic

Gascón, Joaquím; Albajar, Pedro; Cañas, Elías; Flores, María; Prat, Jordi; Herrera, Ramón N.; LaFuente, Carlos; Luciardi, Héctor; Moncayo, Álvaro; Molina, Lluís; Muñóz, José; Puente, Sabino; Sanz, Ginés; Treviño, Begoña; Sergio-Salles, Xavier

doi:10.1016/s1885-5857(07)60153-4

Cited by 67 publications

(58 citation statements)

References 43 publications

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“…An abnormal electrocardiogram (ECG) may be apparent for years prior to the appearance of symptoms such as cardiomegaly. Therefore, an ECG can be used for the early detection of chronic Chagas' disease in patients with a known T. cruzi infection (222). Echocardiography and chest radiography are also employed to detect heart abnormalities associated with chronic Chagas' disease (222).…”

Section: Trypanosomamentioning

confidence: 99%

“…The management of Chagasic heart disease is usually dependent on individual patient circumstances (44,221,437,481). For the treatment of bradyarrhythmias, a pacemaker can be fitted (222).…”

Section: Trypanosomamentioning

confidence: 99%

“…For the treatment of bradyarrhythmias, a pacemaker can be fitted (222). For the treatment of certain ventricular arrhythmias, a cardioverter defibrillator may be implanted (222). Patients with refractory heart failure are usually assessed as candidates for heart transplantation (222).…”

Section: Trypanosomamentioning

confidence: 99%

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Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

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SUMMARY There are many neglected nonenteric protozoa able to cause serious morbidity and mortality in humans, particularly in the developing world. Diseases caused by certain protozoa are often more severe in the presence of HIV. While information regarding neglected tropical diseases caused by trypanosomatids and Plasmodium is abundant, these protozoa are often not a first consideration in Western countries where they are not endemic. As such, diagnostics may not be available in these regions. Due to global travel and immigration, this has become an increasing problem. Inversely, in certain parts of the world (particularly sub-Saharan Africa), the HIV problem is so severe that diseases like microsporidiosis and toxoplasmosis are common. In Western countries, due to the availability of highly active antiretroviral therapy (HAART), these diseases are infrequently encountered. While free-living amoebae are rarely encountered in a clinical setting, when infections do occur, they are often fatal. Rapid diagnosis and treatment are essential to the survival of patients infected with these organisms. This paper reviews information on the diagnosis and treatment of nonenteric protozoal diseases in immunocompromised people, with a focus on patients infected with HIV. The nonenteric microsporidia, some trypanosomatids, Toxoplasma spp., Neospora spp., some free-living amoebae, Plasmodium spp., and Babesia spp. are discussed.

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Section: Trypanosomamentioning

confidence: 99%

“…The management of Chagasic heart disease is usually dependent on individual patient circumstances (44,221,437,481). For the treatment of bradyarrhythmias, a pacemaker can be fitted (222).…”

Section: Trypanosomamentioning

confidence: 99%

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Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

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“…Observed symptoms include neurological disorders and, specially, myocardiopathy with or without congestive heart failure (CHF) and development of digestive megaviscerae such as megacolon and megaoesophagus. [10] This clinical evolution along with a social context of migrants from endemic countries is complicated further by the limited availability of resources, job opportunities and poor knowledge of the seroprevalence of the disease (limited to blood donors and patients of maternity units). The complexity of the issue increases with biased information systems, the possession of a residence card and stigmatization of migrants with a lower socioeconomic status and the poor knowledge of the disease that both the medical class and general European population have.…”

Section: Introductionmentioning

confidence: 99%

Knowledge of Chagas disease in a bolivian population living in Valencia, Spain

Salvador-Gil

Usero-Ruiz

Muñoz-Miguel

et al. 2017

JER

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Fundamentals: Migration movements between countries have enabled the extension of Chagas disease to non-endemic countries such as Spain, where only recently there has been awareness of this emerging global disease and procedures have been put in place for its management. The objective of this study is to determine the level of knowledge of Chagas disease, its symptoms, means of transmission and places where seropositive residents in Valencia (Spain) may seek medical assistance. Methods: Observational cross-sectional study of 96 Bolivian migrants living in Valencia (Spain). The sample was randomly selected and taking advantage of the bolivian elections in 2014. A specific epidemiological survey was conducted and screening blood tests were carried out using ELISA and confirmatory diagnosis by indirect immunofluorescence. After the bivariate analysis, logistic regression models were created to determine the variables that accounted for the lack of knowledge of the disease Results: The prevalence of Chagas was 35.4%. However, 24% of the total sample and 26.1% of seropositive participants do not know about the disease and 70.8% of participants do not know about the symptoms of the disease. While 58.3% (41.1% of seropositive participants) ignore what the means of transmission in non-endemic countries are and 47.1% do not know where to seek medical attention. This ignorance is predominant in participants over 45 years of age and with lower levels of education. Conclusions: There is an important lack of knowledge of the disease which, along with the issue of a high prevalence, elevates Chagas disease into being a potential public health problem which requires specific control and preventive measures.

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“…A maior parte dos casos de infecção é produzida pelo contato da pele ou mucosas com as fezes ou urina de insetos hematófagos da família Reduviidae (subfamília Triatominae), contaminados com T.cruzi (CHAGAS, 1909). Os principais mecanismos de infecção são: transmissão 1 vetorial, congênita, amamentação e via transfusional (GASCÓN et al, 2007). Existem também formas de transmissões excepcionais como: acidental em laboratório, por transplantes de órgãos, oral e sexual (BRENER et al, 2000).…”

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Orquiectomia e administração de dehidroepiandrosterona (DHEA) em ratos Wistar infectados com 'Trypanosoma cruzi'

Filipin¹

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Diagnosis, Management, and Treatment of Chronic Chagas' Heart Disease in Areas Where Trypanosoma cruzi Infection Is Not Endemic

Cited by 67 publications

References 43 publications

Importance of Nonenteric Protozoan Infections in Immunocompromised People

Importance of Nonenteric Protozoan Infections in Immunocompromised People

Knowledge of Chagas disease in a bolivian population living in Valencia, Spain

Orquiectomia e administração de dehidroepiandrosterona (DHEA) em ratos Wistar infectados com 'Trypanosoma cruzi'

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