Diagnosis of active tuberculosis by e-nose analysis of exhaled air

Bruins, Marjan J.; Rahim, Zeaur; Bos, A.; Sande, Wendy W. J. van de; Endtz, Hubert P.; Belkum, Alex van

doi:10.1016/j.tube.2012.10.002

Cited by 122 publications

(87 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…De laatste jaren is er bij de diagnostiek steeds meer aandacht gekomen voor het gebruik van VOC-patroonherkenning in uitademingslucht bij een brede variatie aan ziektebeelden (o. a. tuberculose, Barret-oesofagus en hoofd-en halstumoren) [15][16][17][18]. Wij vonden slechts twee studies over het vaststellen van prostaatkanker op basis van uitademingsluchtanalyse.…”

Section: Discussieunclassified

Opsporen van prostaatkanker in uitademingslucht met behulp van een draagbare elektronische neus

Waltman

Roermund

2018

Tijdschr Urol

View full text Add to dashboard Cite

SamenvattingDe laatste jaren zijn verschillende non-invasieve technieken onderzocht om opsporing van prostaatkanker te verbeteren. Dit onderzoek gaat over de analyse van uitademingslucht door een geavanceerde, gebruiksvriendelijke en draagbare elektronische neus, de Aeonose Trefwoorden prostaatkanker · uitademingslucht · elektronische neus · volatile organic compound (VOC)Detecting prostate cancer by analyzing exhaled-breath using a portable electronic nose (Aeonose TM ) Abstract In the last decade, several non-invasive methods have been researched in order to improve detection of prostate cancer (PCa). This study investigated the possibility of detecting PCa based on exhaled-breath analysis using an advanced, easy-to-use, portable electronic nose ('Aeonose TM '). Exhaled-breath was probed from 85 patients. Within this population, 32 were diagnosed with primary PCa, and 53 patients were used as controls: 30 having negative biopsies, 23 with benign prostate hyperplasia. In order to differentiate between groups, an artificial neural network was trained. This trained model showed an area under the curve of 0.79 with a sensitivity and specificity of 0.84 (95% CI = 0.66-0.94) and 0.70 (95% CI = 0.55-0.81) respectively, when comparing primary PCa and controls. Negative predictive value found was 0.88. In conclusion, these promising results imply Aeonose™ exhaled-breath analysis can be used to detect PCa.Keywords prostate cancer · exhaled-breathe · electronic nose · volatile organic compounds (VOCs) IntroductieAl sinds de Griekse oudheid is bekend dat uitademingslucht informatie bevat over iemands gezondheidstoestand. Uit onderzoek is gebleken dat honden een zeer goed ontwikkeld reukorgaan hebben en concentraties van 0,001 deeltjes

show abstract

Section: Discussieunclassified

Opsporen van prostaatkanker in uitademingslucht met behulp van een draagbare elektronische neus

Waltman

Roermund

2018

Tijdschr Urol

View full text Add to dashboard Cite

show abstract

“…A sensitive, fast, easyto-operate and low-cost method is urgently needed. 1 The so-called "E-Nose" is a battery-operated device, similar to an alcohol breathalyser, which offers a rapid and accurate diagnosis. 1 A patient simply blows into the device, and sensors pick up TB biomarkers in the breath droplets.…”

mentioning

confidence: 99%

“…1 The so-called "E-Nose" is a battery-operated device, similar to an alcohol breathalyser, which offers a rapid and accurate diagnosis. 1 A patient simply blows into the device, and sensors pick up TB biomarkers in the breath droplets. One big advantage of this hand-held, battery powered device is that testing can be done at village level so people do not have to make the trip to distant hospitals or clinics for timeconsuming testing with sputum.…”

mentioning

confidence: 99%

“…The result showed sensitivity of 95.9% and specificity of 98.5% for the pilot study and in the validation study a sensitivity of 93.5% and a specificity of 85.3% discriminating healthy controls from TB patients, and a sensitivity of 76.5% and specificity of 87.2% when identifying TB patient within the entire test-population (best-case numbers). 1 In the pilot study, two sub-studies were conducted at icddr,b's tuberculosis laboratory of Dhaka in Bangladesh, in collaboration with the Government of Bangladesh's National TB Control Programme. 'Electronic nose' technology was used to analyze exhaled lung air samples from 15 TB patients admitted to Dhaka's National Institute of Diseases of the Chest and Hospital.…”

mentioning

confidence: 99%

See 1 more Smart Citation

E-Nose: An Easier Test for Tuberculosis

2013

View full text Add to dashboard Cite

Tuberculosis (TB), a highly infectious airborne disease, remains a major global health problem. Many of the new diagnostic techniques are not suited for operation in the highly-endemic low-income countries. A sensitive, fast, easyto-operate and low-cost method is urgently needed. 1 The so-called "E-Nose" is a battery-operated device, similar to an alcohol breathalyser, which offers a rapid and accurate diagnosis. 1 A patient simply blows into the device, and sensors pick up TB biomarkers in the breath droplets. One big advantage of this hand-held, battery powered device is that testing can be done at village level so people do not have to make the trip to distant hospitals or clinics for timeconsuming testing with sputum. 2 Some of the specific volatile organic compounds (VOC) associated with Mycobacteria tuberculosis organisms are now being discovered and a paper was published in 2008, but the method of predicting the presence of TB in sputum samples using the VOC biomarkers has yet to be fully optimised. Sensitivity and specificity levels for field detection of TB have been set by WHO at a minimum level of 85% and 95% respectively, and the e nose technique is working towards these figures. In a series of experiments carried out in Mbeya, Tanzania, Africa, data from a full 5 days of sampling was combined giving a total of 248 sputum samples analyzed. From the data obtained results showed specificities and sensitivities in the 70-80% region when actually predicting the presence of TB in unknown sputum samples. 3 In another study the potential of two different electronic noses (EN; code named "Rob" and "Walter") were used to differentiate between sputum headspace samples from tuberculosis (TB) patients and non-TB patients. Only samples from Ziehl-Neelsen stain (ZN)-and Mycobacterium tuberculosis culture-positive (TBPOS) sputum samples and ZN-and culture-negative (TBNEG) samples were used for headspace analysis. With EN Rob, 284 samples from TB suspects (56 TBPOS and 228 TBNEG samples), and with EN Walter, 323 samples from TB suspects (80 TBPOS and 243 TBNEG samples) were investigated. The best results were obtained using advanced data extraction and linear discriminant function analysis, resulting in a sensitivity of 68%, a specificity of 69%, and an accuracy of 69% for EN Rob; for EN Walter, the results were 75%, 67%, and 69%, respectively. 4 In another study in Amsterdam and Zambia the headspaces of cultures, spiked sputa, and sputum samples from 330 culture proven and human immunodeficiency virus-tested TB and non-TB patients. The EN differentiated between different Mycobacterium spp. and between mycobacteria and other lung pathogens both in culture and in spiked sputum samples. The EN correctly predicted 89% of culturepositive patients; the six false negatives were the four ZNnegative and two ZN-positive patients. The specificity and sensitivity were 91% and 89%, respectively, compared to culture. At present, the reasons for the false negatives and false positives are unknown, but they could well be due to...

show abstract

“…A kilélegzett levegő analízis területén ígéretes lehet az elektronikus orr (electronic nose), amely különböző (egymástól eltérő) karakterisztikájú és szelektivitású szenzorokból, jelfeldolgozó és adatgyűjtő rendszerből, valamint alakzatfelismerő algoritmusból áll [35]. Magyarországon a Semmelweis Egyetemen végeznek elektronikus orr készülékekkel kutatásokat [36].…”

Section: Akusztikus Rezonátorokunclassified

Fotoakusztikus spektroszkópia alkalmazási lehetőségei a kilélegzett levegő gázösszetételének vizsgálatában

Szabó

View full text Add to dashboard Cite

Diagnosis of active tuberculosis by e-nose analysis of exhaled air

Cited by 122 publications

References 19 publications

Opsporen van prostaatkanker in uitademingslucht met behulp van een draagbare elektronische neus

Opsporen van prostaatkanker in uitademingslucht met behulp van een draagbare elektronische neus

E-Nose: An Easier Test for Tuberculosis

Fotoakusztikus spektroszkópia alkalmazási lehetőségei a kilélegzett levegő gázösszetételének vizsgálatában

Contact Info

Product

Resources

About