Diagnosis of Food Allergy

Chinthrajah, R. Sharon; Tupa, Dana; Prince, Benjamin; Block, Whitney; Rosa, Jaime S.; Singh, Anne Marie; Nadeau, Kari

doi:10.1016/j.pcl.2015.07.009

Cited by 43 publications

(31 citation statements)

References 137 publications

(119 reference statements)

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“…Whereas IgE-mediated allergies to cow's milk, egg, wheat and soy tend to be outgrown, atopic responses to peanuts, tree nuts and shellfish usually persist into adulthood 17 . The most common IgE-mediated food allergies vary somewhat by region and with dietary habits; for example, children in Ghana between 5 and 16 years of age are commonly allergic to pineapple, pawpaw, orange and mango, as well as to peanut 18 , whereas children in North America are commonly allergic to peanut, milk, egg, shellfish and soy 4 .…”

Section: Classification Of Food Allergiesmentioning

confidence: 99%

“…When IgE-mediated food allergy is suspected, measurements of total and allergen-specific serum IgE (sIgE) levels and skin prick tests (SPTs) are recommended to identify the causative food, although they are not in themselves diagnostic 16 . Increased sIgE levels may suggest food allergy, and sIgE thresholds with a 95% positive predictive value have been determined for some food allergens; for example, in peanut-allergic patients, the threshold sIgE level for peanut antigen is 14 kU A /L (U A = allergen-specific units; 1 unit ≈ 2.4 ng IgE) 17,92,93 . SPTs provoke allergen-mediated mast cell degranulation in the skin, leading to wheal-and-flare reactions.…”

Section: Diagnostic Tests For Food Allergiesmentioning

confidence: 99%

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Food allergy: immune mechanisms, diagnosis and immunotherapy

2016

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Food allergy is a pathological, potentially deadly, immune reaction triggered by normally innocuous food protein antigens. The prevalence of food allergies is rising and the standard of care is not optimal, consisting of food-allergen avoidance and treatment of allergen-induced systemic reactions with adrenaline. Thus, accurate diagnosis, prevention and treatment are pressing needs, research into which has been catalysed by technological advances that are enabling a mechanistic understanding of food allergy at the cellular and molecular levels. We discuss the diagnosis and treatment of IgE-mediated food allergy in the context of the immune mechanisms associated with healthy tolerance to common foods, the inflammatory response underlying most food allergies, and immunotherapy-induced desensitization. We highlight promising research advances, therapeutic innovations and the challenges that remain.

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Section: Classification Of Food Allergiesmentioning

confidence: 99%

Section: Diagnostic Tests For Food Allergiesmentioning

confidence: 99%

Food allergy: immune mechanisms, diagnosis and immunotherapy

2016

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“…IgE aracılı besin allerjisi tanısında en önemli araç besin alımı ile ortaya çıkan klinik hikaye varlığında deri testi veya kan testi ile besin spesifik IgE'nin gösterilmesidir (19). Her ne kadar altın standart besin provokasyon testi olsa da ilk basamakta spesifik IgE varlığının araştırılması hekime yol gösterir (20,21).…”

Section: Bulgularunclassified

“…Besin allerjisi tanısında besin provokasyon testi altın standarttır (19), fakat özellikle 6 ay altında her zaman mümkün olmamaktadır. Bu çalışmada deri testinde duyarlanma saptanan her hastada ilgili besin diyetten çıkarıldığında atopik dermatit semptomlarında gerileme tespit edilmiştir.…”

unclassified

Food Hypersensitivity in Atopic Dermatitis During Infancy: Skin Prick Testing for Whom?

Emeksiz

Cavkaytar

Aksoy

et al. 2017

Asthma Allergy Immunol

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ÖZGiriş: Atopik dermatit (AD) bebeklik döneminde sık görülen bir hastalıktır. Yaşamın ilk 6 ayında, özellikle ilk 3 ayında başvuran AD'li hastalarda besin duyarlılığı konusunda veri kısıtlıdır. Çalışmada AD tanısı almış bebeklerde başvuru zamanına göre besin duyarlılığı(BD) sıklığının ve ilişkili faktörlerin ortaya konulması amaçlanmıştır.Gereç ve Yöntem: Çalışmamıza S.B. Ankara Eğitim Araştırma Hastanesi Çocuk Allerji ve İmmünoloji Kliniği'ne başvuran AD'li bir yaşından küçük hastalar dahil edildi. Hastaların demografik özellikleri, beslenme durumları, hastalık şiddetleri, deri testi sonuçları kaydedildi. Besin duyarlılığı tanısı varlığında besin deri testi pozitifliği ile kondu. Deri testi pozitif olan hastaların tümü ilgili besinin diyetten eliminasyonundan fayda gördü. Bulgular: Çalışmaya 110 (%70'i erkek) hasta alındı, 23 (%21.6) bebek BD tanısı aldı. Üç aylık ve daha küçük AD'li hastalarda BD olanlarda olmayanlara göre SCORAD indeksi [(25.2 (20.9-34.9 Sonuç: Üç aylık ve daha küçük AD'li bebeklerde serum total IgE düzeyi ve SCORAD indeksi, 3-6 ay arasında ise ek olarak eozinofil ABSTRACT Objective: Atopic dermatitis (AD) is a common disease during infancy. The data on food hypersensitivity (FH) in the first six months and especially in the first three months of life is limited in children with AD. The aim of this study was to find out the frequency of FH and related factors in infants with AD in regard to their referral age. Materials and Methods:Infants younger than 1 years of age who were diagnosed as AD at the Ankara Training and Research Hospital's Department of Pediatrics were included in our study. The demographic features, nutritional status, disease severity and skin test results were recorded. A diagnosis of FH was made in the presence of a positive skin test with the related allergen. All the patients with FH had resolution of the symptoms with the elimination of the relevant food from the diet.Results: One-hundred and ten patients (70% male) were included. In patients younger than 3 months of age, the SCORAD-index and total IgE levels were higher in the patients with FH compared to patients without FH [(25.2(20.9-34.9) vs. 19.2(13.1-24.2), (p=0.034) and 22.2(11.6-52.6)kU/L vs. 4(4-10)kU/L, (p=0.04), respectively]. In patients aged between 3 and 6 months of age, the SCORAD index, total IgE and eosinophil levels were higher in patients with FH compared to patients without .7), (p<0.001)], [42.1(6.3-283)kU/L vs. 8.3(4.8-8.3)kU/L, (p=0.033)], [7.5%(3.9-9.7) vs. 3.5%(1.8-5.8), (p=0.01)]. In patients older than 6 months of age, the SCORAD index, eosinophil and IgE levels were similar between patients with and without FH.

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“…Puede presentarse en forma aislada (80%) o en el contexto ejercicio. [29][30][31] de una anafilaxia (20%).…”

Section: Patologíasunclassified