Diagnosis of hantavirus infection in humans

Máttar, Salim; Guzmán, Camilo; Figueiredo, LF Poli de

doi:10.1586/14787210.2015.1047825

Cited by 53 publications

(56 citation statements)

References 48 publications

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“…Además, esta técnica implica el contacto directo con el virus que es altamente infectivo, por lo que debe realizarse solamente en laboratorios de nivel de bioseguridad de categoría cuatro. Desde 1993 han sido creadas RCP-TI (reacción de la cadena de la polimerasa acoplada a transcriptasa inversa) específicas para hantavirus que pueden ser utilizadas en laboratorios de categoría tres y que permiten el diagnóstico del virus en la fase aguda de la enfermedad, Sin embargo, la sensibilidad de este test disminuye en la fase de convalecencia (38,39). En la práctica corriente, la serología es el método más utilizado para el diagnóstico de la enfermedad.…”

Section: Síndrome Febril Hemorrágico Con Compromiso Renalunclassified

“…Since 1993, hantavirus-specific PCR-RI have been created to be used in category three labs, and which allow diagnosis during the acute stage of the disease. However, the sensitivity of this test is reduced during the convalescence stage (38,39). In ordinary practice, serology is the most common used method to diagnose the disease.…”

Section: Diagnosismentioning

confidence: 99%

“…Almost every patient with SPH have a positive titer of IgM at the moment of evaluation. In a patient with a compatible clinical picture, the presence of positive ELISA titer or positive IFA IgM, allows for a presumptive diagnosis, which must be confirmed with the increase of IgG titers after 4 weeks (35,38,39). con el aumento de los títulos de IgG a distancia de 4 semanas (35,38,39).…”

Section: Diagnosismentioning

confidence: 99%

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Infecciones por hantavirus

Tous

et al. 2017

Rev MVZ Córdoba

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Hantaviruses are the causative agents of hantavirus pulmonary syndrome in humans in the Americas; The primary reservoirs are in the rodents of the subfamily Sigmodontinae. In South America, cases of hantavirus pulmonary syndrome caused by numerous viral genotypes have been diagnosed. In Colombia, different serological studies have reported the circulation of hantavirus in humans and rodents. These viruses act in an intimate association with a rodent species that serves as a reservoir and have a distribution around the wild rodent, being limited to a specific geographic region. In South America, the first HPS-associated hantavirus was described in 1993 in Brazil and was called Juquitiva and from 1993 to 2012, more than 1400 cases had been identified in Brazil. This syndrome should be suspected in all patients with respiratory distress syndrome of unclear etiology, in areas endemic for the disease, especially if accompanied by fever, marked leukocytosis and thrombocytopenia and bilateral interstitial infiltrates. Hemorrhagic febrile syndrome has not yet been described in the Americas. There are no clinical or laboratory signs that are pathognomonic of hantavirus infection. The treatment is based on adequate hydration, use of antipyretics and anti-inflammatories and patients with signs of severity should establish a more aggressive management. Triage is indispensable, patients with co-morbidities have a higher mortality risk and therefore should be hospitalized. Future research in Colombia should be directed to multidisciplinary studies that include viral isolation, different clinical forms of case presentation, epidemiological differences, risk factors, and taxonomy of viruses and rodents.Keyswords: Arenavirus, bunyaviridae, reservoirs, rodentia, public health (Source: DeCS). RESUMENLos hantavirus, virus que son los agentes causantes de síndrome pulmonar por hantavirus en humanos en America; los reservorios primarios están en los roedores de la sub-familia Sigmodontinae. En Suramérica, se han diagnosticado casos del síndrome pulmonar por hantavirus y se han identifico numerosos genotipos virales. En Colombia, se han publicado diferentes estudios serológicos que reportaron la circulación de hantavirus en humanos y roedores. Estos virus actúan en una íntima asociación con una especie de roedor que le sirve de reservorio y presentan una distribución alrededor del roedor silvestre, limitándose a una región geográfica especifica. En Suramérica, el primer hantavirus asociado a SPH fue descrito en 1993 en Brasil y se denominó Juquitiva y desde 1993 hasta el 2012, se habían identificado más de 1400 casos en Brasil. Se debe sospechar de este síndrome en todo paciente con síndrome de distrés respiratorio de etiología no clara, en las zonas endémicas para la enfermedad sobre todo si se acompaña de fiebre, leucocitosis marcada y trombocitopenia e infiltrados intersticiales bilaterales. El síndrome febril hemorrágico aún no se han descrito casos en las Américas. No existen signos clínicos o de laboratorio que sean pato...

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Section: Síndrome Febril Hemorrágico Con Compromiso Renalunclassified

Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

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Infecciones por hantavirus

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et al. 2017

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“…A proportion of 13-47% of these patients may require haemodialysis. During this phase ECG abnormalities are common with 38% of patients in some series presenting rhythm and conduction abnormalities [18]. The Polyuric and Convalescence stages follow (weeks to months), with patient clinical improvement, and synchronous electrolyte abnormalities due to polyuria (reaching 3-6 liters of urine output daily) [16].…”

Section: Epidemiology Clinical Features and Disease Severity Of Hantmentioning

confidence: 99%

“…Other diagnostic tools (Microarray, Next Generation Sequencing, Cell culture isolation) are used mainly in virus discovery and further virological and functional studies, being however too expensive and complex for routing use in clinical practice [18].…”

Section: Diagnosis Treatment and Prevention Of Diseasementioning

confidence: 99%

Hantavirus Infections in the European Region: A Mini-Review of the Literature

Panos¹

2017

JMEN

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Hantaviruses

Klena,

Chiang,

Whitmer

et al. 2023

ClinMicroNow

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This chapter provides taxonomy, description of the agents, epidemiology and transmission, clinical significance, collection, transport, and storage of species, direct examination, and identification of Hantaviruses. Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) are rodent‐borne zoonoses caused by several members of the virus family Hantaviridae , genus Orthohantavirus . Diagnosis early in the course of disease is critical to the successful management of HFRS and HPS. The clinical and pathological features of severe HFRS and HPS are associated with acute thrombocytopenia and a reversible increase in microvascular (capillary) permeability. Immunohistochemistry has been used to detect hantaviral antigens in tissues from fatal HFRS cases, biopsy materials from nephropathia epidemica cases, and tissues from fatal HPS cases. There are a number of reference diagnostic laboratories in United States that offer laboratory testing, such as serologic testing. Isolation of hantavirus from natural hosts is difficult yet necessary for analyzing biological properties of these viruses.

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Diagnosis of hantavirus infection in humans

Cited by 53 publications

References 48 publications

Infecciones por hantavirus

Infecciones por hantavirus

Hantavirus Infections in the European Region: A Mini-Review of the Literature

Hantaviruses

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