Diagnosis of <scp>H</scp>elicobacter pylori infection in gastric mucosa by endoscopic features: <scp>A</scp> multicenter prospective study

Kato, Takeshi; Yagi, Nobuaki; Kamada, Takenobu; Shimbo, Takuro; Watanabe, Hidenobu; Ida, Kazunori

doi:10.1111/den.12031

Cited by 129 publications

(143 citation statements)

References 16 publications

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“…The risk stratification by serum marker was accurate in a majority of younger subjects, suggesting that the ABC classification system (or risk stratification by Hp-Ab) for gastric cancer screening should be applied especially in younger subjects. However, in elderly patients, a single endoscopic examination may be sufficient to eliminate the problem of misdiagnosing gastric cancer risk [18]. The reason for the contamination of patients with CAG in group A remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…We speculated that the natural clearance of H. pylori may be one reason [11]. This seems reasonable because the prevalence of H. pylori infection itself is significantly higher in elderly Japanese patients [18] and that elderly subjects with H. pylori infection are much more likely to experience natural clearance when using antibiotics for a reason other than H. pylori eradication therapy.…”

Section: Discussionmentioning

confidence: 99%

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Serological Evaluation of Gastric Cancer Risk Based on Pepsinogen and Helicobacter pylori Antibody: Relationship to Endoscopic Findings

et al. 2017

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Backgrounds and Aims: The serological risk-prediction system combined the pepsinogen (PG) test, and anti-Helicobacter pylori antibody is available for evaluation of gastric cancer risk. In this system, chronic atrophic gastritis (CAG) or H. pylori infection is diagnosed. Subjects with H. pylori negative and PG test negative (group A) are supposed to be those who have never been infected with H. pylori and are at extremely low risk for gastric cancer. However, a certain proportion of patients with CAG has been identified as the extremely low-risk group (group A). Here we examined endoscopic atrophy and investigated its relationship with the ABC classification system. Methods: We examined 540 patients. All patients underwent an endoscopic examination for evaluating corpus atrophy. Fasting sera were collected and serum PGs and anti-H. pylori antibody (Hp-Ab) titer (E-plate Eiken) were evaluated. Results: Of the 540 patients, 306 were classified into group A. However, 136 of them showed signs of endoscopic atrophy (group A with CAG). Group A with CAG frequently comprised the elderly. A new titer cut-off (<3 U/mL) of the Hp-Ab improved the discrimination of group A with CAG by 8%. Conclusion: The prevalence of group A with CAG patients is a critical problem, especially in elderly subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serological Evaluation of Gastric Cancer Risk Based on Pepsinogen and Helicobacter pylori Antibody: Relationship to Endoscopic Findings

et al. 2017

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“…Although gastroscopic features of H. pylori associated gastritis have been reported in the literature, endoscopic diagnosis of H. pylori infection of the gastric mucosa by using conventional endoscopy and an Indigo carmine contrast method may be possible (Takahiro Kato et al, 2013 enhanced visualization of mucosal microscopic structuress and capillaries in the superficial mucosal layer. Images are obtained by using Narrow Band red, blue, and green filters, which are different from conventional red-green-blue filters (Gono et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Improved Detection of Helicobacter pylori Infection and Premalignant Gastric Mucosa Using "Site Specific Biopsy": a Randomized Control Clinical Trial

Tongtawee¹,

Dechsukhum²,

Leeanansaksiri³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Helicobacter pylori infection and premalignant gastric mucosa can be reliably identified using conventional narrow band imaging (C-NBI) gastroscopy. The aim of our study was to compare standard biopsy with site specific biopsy for diagnosis of H. pylori infection and premalignant gastric mucosa in daily clinical practice. Materials and Methods: Of a total of 500 patients who underwent gastroscopy for investigation of dyspeptic symptoms, 250 patients underwent site specific biopsy using C-NBI (Group 1) and 250 standard biopsy (Group 2). Sensitivity, specificity, and positive and negative predictive values were assessed. The efficacy of detecting H. pylori associated gastritis and premalignant gastric mucosa according to the updated Sydney classification was also compared. Results: In group 1 the sensitivity, specificity, positive and negative predictive values for predicting H. pylori positivity were 95.4%, 97.3%, 98.8% and 90.0% respectively, compared to 92.9%, 88.6%, 83.2% and 76.1% in group 2. Site specific biopsy was more effective than standard biopsy in terms of both H. pylori infection status and premalignant gastric mucosa detection (P<0.01). Conclusions: Site specific biopsy using C-NBI can improve detection of H. pylori infection and premalignant gastric mucosa in daily clinical practice.

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“…Kato et al 8 reported that H. pylori seroconversion after eradication occurs after ≥ 24 months. Moreover, serum IgG to H. pylori Cag A antigen persists for a long time after H. pylori disappearance 10 , in some cases for several decades.…”

Section: Discussionmentioning

confidence: 99%

“…Endoscopic diagnoses were confirmed by at least two digestive endoscopic specialists either in real time or retrospectively. Regular arrangement of collecting venules RAC at the gastric angle is a typical sign of being naïve to H. pylori infection 7,8 . Conversely, the absence of RAC at the angle or chronic atrophic gastritis CAG is a finding typical of current or previous H. pylori infection.…”

Section: Methodsmentioning

confidence: 99%

Serum Helicobacter Pylori IgG Titers are Predictive of H. pylori Infection Status

Inui

Ohwada²,

Ishida

et al. 2016

Showa Univ J Med Sci

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: The aim of the present study was to test the hypothesis that a novel serum Helicobacter pylori IgG kit derived from Japanese H. pylori strains, namely the Sphere Light H. pylori IgG J kit SL-HP J , would enable discrimination of H. pylori infection status. In total, 273 patients were enrolled in the study and underwent endoscopic examination at Inui Clinic of Internal Medicine. Serum H. pylori IgG titers were measured using the SL-HP J kit. Current H. pylori infection was de ned as positivity in at least one H. pylori test rapid urease test, urease breath test, monoclonal stool antigen test, or histology , excluding serology. Naïve H. pylori infection was de ned as negativity in all H. pylori tests and chronic atrophic gastritis CAG , as determined by endoscopy. Previous H. pylori infection was de ned as negativity for all H. pylori tests despite the presence of CAG. After testing, 134 patients were deemed to be naïve to H. pylori infection, 83 patients were diagnosed with current H. pylori infection, and the remaining 56 patients were diagnosed with previous H. pylori infection. Median quartile deviation titers in patients with naïve, previous, and current H. pylori infection were 0.8 0.4, 2.1 2.3, and 24.8 22.7 U / ml, respectively. The receiver operating characteristic ROC curve for naïve and previous H. pylori infection to classify naïve H. pylori infection showed an area under the curve AUC of 0.910, with 83 sensitivity and 82 speci city for a cut-off level of 1.6 U / ml ; the ROC curve for previous and current H. pylori infection to classify current H. pylori infection had an AUC of 0.969, with 96 sensitivity and 88 speci city for a cut-off level of ≥ 3.3 U / ml. The present study shows that serum H. pylori IgG titers may be used to determine H. pylori infection status.

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Diagnosis of Helicobacter pylori infection in gastric mucosa by endoscopic features: A multicenter prospective study

Abstract: It is suggested that endoscopic diagnosis of H. pylori infection in gastric mucosa by conventional endoscopy and the IC method is mostly possible.

Cited by 129 publications

References 16 publications

Serological Evaluation of Gastric Cancer Risk Based on Pepsinogen and <b><i>Helicobacter pylori </i></b>Antibody: Relationship to Endoscopic Findings

Serological Evaluation of Gastric Cancer Risk Based on Pepsinogen and <b><i>Helicobacter pylori </i></b>Antibody: Relationship to Endoscopic Findings

Improved Detection of Helicobacter pylori Infection and Premalignant Gastric Mucosa Using "Site Specific Biopsy": a Randomized Control Clinical Trial

Serum <i>Helicobacter Pylori</i> IgG Titers are Predictive of <i>H. pylori</i> Infection Status

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