Diagnosis of Neonatal Transient Tachypnea and Its Differentiation From Respiratory Distress Syndrome Using Lung Ultrasound

Liu, Jing; Wang, Yan; Fu, Wei; Yang, Chang-shuan; Huang, Jun-jin

doi:10.1097/md.0000000000000197

Cited by 106 publications

(101 citation statements)

References 17 publications

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“…Our data confirms a high index of agreement between LUS and the final diagnosis for the major causes of neonatal respiratory distress, as previously reported [9,11,12,14,22]. …”

Section: Discussionsupporting

confidence: 76%

“…We obtained a high specificity according to other series [9,21]. We took the double lung point as suggestive of TTN based on the 100% sensitivity reported by Copetti and Cattarossi [9], although Liu et al [22] published a sensitivity of 76.7% after our data had already been collected. There were 8 patients admitted for respiratory distress whose symptoms were due to extrapulmonary diseases, and they were included in the low-risk group.…”

Section: Discussionmentioning

confidence: 99%

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Lung Ultrasound as a Predictor of Mechanical Ventilation in Neonates Older than 32 Weeks

et al. 2016

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Background: The prognosis of neonatal respiratory distress may be difficult to estimate at admission. Lung ultrasound is a useful diagnostic tool that is quick, requires little training, and is radiation free. Objective: This study aims to analyze whether early lung ultrasound can predict respiratory failure. Methods: From January to December 2014, lung ultrasound was performed on neonates admitted with breathing difficulties if they were older than 32 weeks and not intubated. A neonatologist, not aware of the patient's clinical condition, analyzed the stored ultrasound images. The findings were classified into the following 2 groups according to the potential risk of a bad respiratory outcome: low risk (normal or transient tachypnea of the newborn) or high risk (respiratory distress syndrome, meconium aspiration syndrome, pneumothorax, or pneumonia). A second investigator made the same classification after reading the chest X-rays. Respiratory failure was defined as a need for mechanical ventilation during the first day of life. Results: In total, 105 neonates were recruited (64.8% in the low-risk sonography group and 35.2% in the high-risk sonography group). Of those, 20% needed intubation, and this was more frequent in the high-risk group (relative risk = 17.5; 95% CI 4.3-70.9, p < 0.01). As predictors of respiratory failure, lung ultrasound and chest X-ray showed a high index of agreement (κ coefficient = 0.91; 95% CI 0.83-1, p < 0.01) and good accuracy (ultrasound: 95% sensitivity, 82.5% specificity, and a negative predictive value of 98.5%). Conclusions: Early lung ultrasound is a useful tool to determine which neonates admitted with respiratory distress will require mechanical ventilation. It may help the clinician to carrying out appropriate transfers.

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“…Our data confirms a high index of agreement between LUS and the final diagnosis for the major causes of neonatal respiratory distress, as previously reported [9,11,12,14,22]. …”

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Lung Ultrasound as a Predictor of Mechanical Ventilation in Neonates Older than 32 Weeks

et al. 2016

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“…Previous studies have reported several LUS features of TTN, with or without DLP, and a variable sensitivity of DLP [4, 6, 7, 16, 17]. Surprisingly, the incidence of DLP was low in our population.…”

Section: Discussioncontrasting

confidence: 47%

A Multicenter Lung Ultrasound Study on Transient Tachypnea of the Neonate

Raimondi

Yousef

Fanjul³

et al. 2019

Neonatology

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Background and Aim: Discordant results that demand clarification have been published on diagnostic lung ultrasound (LUS) signs of transient tachypnea of the neonate (TTN) in previous cross-sectional, single-center studies. This work was conducted to correlate clinical and imaging data in a longitudinal and multicenter fashion. Methods: Neonates with a gestational age of 34–40 weeks and presenting with TTN underwent a first LUS scan at 60–180 min of life. LUS scans were repeated every 6–12 h if signs of respiratory distress persisted. Images were qualitatively described and a LUS aeration score was calculated. Clinical data were collected during respiratory distress. Results: We enrolled 65 TTN patients. Thirty-one (47.6%) had a sharp echogenicity increase in the lower lung fields (the “double lung point” or DLP sign). On admission, there was no significant difference between patients with and without DLP in Silverman scores (4 ± 1.5 vs. 4 ± 2.1; p = 0.9) or LUS scores (7.6 ± 2.6 vs. 5.6 ± 3.8; p = 0.12); PaO₂/FiO₂ (249 ± 93 vs. 252 ± 125; p = 0.91). All initial LUS scans (performed at the onset of distress) and 99.5% of all scans showed a regular pleural line with no consolidation, with only 1 neonate showing consolidation in the follow-up scans. The Silverman and LUS scores were significantly correlated (rho = 0.27; p = 0.02). Conclusion: A regular pleural line with no consolidation is a consistent finding in TTN. The presence of a DLP is not essential for the LUS diagnosis of TTN. A semi-quantitative LUS score correlates well with the clinical course and could be useful in monitoring changes in lung aeration during TTN.

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“…TTN is a common cause of dyspnea in the newborn. The incidence rates of TTN are 4.0% to 5.7% among term infants and 10.0% in premature infants (1). The risk factors associated with TTN includes; prematurity, male sex, large birth weight, meconium-stained amniotic fluid, cesarian section delivery(esp.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Inhaled Salbutamol in Transient of Tachypnea of the Newborn: A Randomized Clinical Trial

et al. 2017

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Background: Transient tachypnea of the newborn (TTN) is a common cause of respiratory distress in the neonatal period. There are few data regarding the pharmacotherapy for the management of TTN. Previous studies documented the therapeutic role for the beta2 agonists in TTN by accelerating the clearance of excessive fluid from the alveolar space. The aim of present study was to assess the effect of salbutamol on major clinical outcomes including duration of oxygen therapy and improvement of respiratory symptoms.

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Diagnosis of Neonatal Transient Tachypnea and Its Differentiation From Respiratory Distress Syndrome Using Lung Ultrasound

Cited by 106 publications

References 17 publications

Lung Ultrasound as a Predictor of Mechanical Ventilation in Neonates Older than 32 Weeks

Lung Ultrasound as a Predictor of Mechanical Ventilation in Neonates Older than 32 Weeks

A Multicenter Lung Ultrasound Study on Transient Tachypnea of the Neonate

The Effect of Inhaled Salbutamol in Transient of Tachypnea of the Newborn: A Randomized Clinical Trial

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