Diagnosis of Osteoarthritis Subtypes with Blood Biomarkers

Abstract

Objective: To identity osteoarthritis(OA) subtypes with gene expression of peripheral blood mononuclear cells. Methods:Gene expression data (GSE48556) of Genetics osteoARthritis and Progression (GARP) study was downloaded from Gene Expression Omnibus.Principal component analysis and unsupervised clustering were analyzed to identify subtypes of OA and compare major KEGG pathways and cell type enrichment using GSEA and xCell. Classification of subtypes were explored by the utilization of support vector machine.

Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis

“…Karsdal et al ( 2014 ) proposed six potential OA subtypes, including low-grade autoimmunity, inflammation, genetic, hormonal, metabolic and mechanotransduction subtypes, and categorized the drivers of OA into at least three different types based on the most active or affected joint tissues, including cartilage, bone and inflamed synovium. Recent work based on transcriptomic profiles of peripheral blood mononuclear cells identified two OA subtypes, a degenerative subtype, and an inflammation related subtype (Zhao et al, 2018 ). Presented below is a discussion of potential OA subtypes on the basis of current reported pathology and intervention studies and clinical findings on the response profile of subchondral bone remodeling.…”