Diagnosis of Regional Node Metastases in Lung Cancer with Computer-Aided 3D Measurement of the Volume and CT-Attenuation Values of Lymph Nodes

Takahashi, Yoshiyuki; Takashima, S; Hakucho, Tomoaki; Miyake, Chie; Morimoto, Daisuke; Jiang, Binghu; Numasaki, Hodaka; Tomita, Yoshihiro; Nakanishi, Katsuyuki; Higashiyama, Masahiko

doi:10.1016/j.acra.2013.01.013

Cited by 12 publications

(14 citation statements)

References 20 publications

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“…Similarly, in a study of tracheobronchial lymph nodes in dogs, it was found that the maximum diameter was significantly longer in metastatic lymph nodes than in normal ones . In humans, lymph nodes with a minimum diameter higher than 5 mm are considered metastatic or reactive with an accuracy varying from 66.7 to 90.5%, whereas the minimum diameter is considered a more reliable diagnostic index than the maximum diameter …”

Section: Discussionmentioning

confidence: 98%

Assessment of Sentinel Lymph Node Metastasis in Canine Mammary Gland Tumors Using Computed Tomographic Indirect Lymphography

Soultani

Patsikas

Karayannopoulou

et al. 2016

Vet Radiology Ultrasound

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In the staging process of the breast cancer, demonstrating metastasis of the sentinel lymph node (SLN) has an important prognostic value, in both humans and animals. The aim of this prospective case-control study was to determine the diagnostic value of computed tomographic indirect lymphography (CT-LG) for detecting SLN metastasis in dogs with mammary cancer. Thirty-three female dogs with tumors in the abdominal and inguinal mammary glands were prospectively selected and subjected to CT-LG, 1 and 5 min after injection of 1 ml of contrast agent (iopamidol) in the subareolar tissue of the neoplastic and the contralateral normal mammary glands. The pattern of postcontrast opacification, degree of postcontrast enhancement, and size and shape were assessed in 65 SLNs in total and were correlated with histopathological findings. The absence of opacification or heterogeneous opacification 1 min after contrast medium injection showed the highest sensitivity, specificity, and accuracy (93%, 100%, and 98.4%, respectively). In images taken 1 min after injection, an absolute density value lower than 444 Hounsfield units (HU) in the center of the SLN also provided significant sensitivity and specificity (93.8% and 75%, respectively). The size and shape of the SLN (maximum and minimum diameter, maximum/minimum diameter ratio, maximum diameter/height of fifth thoracic vertebral body ratio) showed the lowest sensitivity and specificity. Results of this study support the hypothesis that CT-LG could help in the assessment of SLN metastasis in cases of mammary gland tumors in dogs.

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Section: Discussionmentioning

confidence: 98%

Assessment of Sentinel Lymph Node Metastasis in Canine Mammary Gland Tumors Using Computed Tomographic Indirect Lymphography

Soultani

Patsikas

Karayannopoulou

et al. 2016

Vet Radiology Ultrasound

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“…A previous study indicated that PET/CT has become feasible for fast imaging and may be used for cancer staging in patients with a malignant condition ( 28 ). In addition, three-dimensional CT measurement may be useful for diagnosing nodal metastases ( 29 ). Notably, the present study determined that single CT diagnosis is insufficient in the diagnosis of patients with NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of marker gene detection and computed tomography for the diagnosis of human lung cancer

et al. 2018

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Non-small cell lung cancer (NSCLC) is one of leading causes of cancer-associated mortality, with a high number of cases caused by metastasis. The early diagnosis of cancer contributes to the successful treatment of patients with lung cancer. The aim of the present study was to analyze the efficacy of marker gene detection and computed tomography (CT) in diagnosing human lung cancer. Lung cancer marker genes, including carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), tissue polypeptide antigen (TPA), pro-gastrin-releasing peptide (ProGRB), cytokeratin fragment 21-1 (Cyfra21-1) and neuron-specific enolase (NSE), were analyzed in patients with lung cancer. The tumor size was evaluated using CT, and the association between lung serum levels of marker gene protein expression and tumor size was investigated. A total of 328 patients with lung cancer were identified, including 204 adenocarcinoma, 75 large cell carcinoma and 49 squamous cell carcinoma cases. All patients were indicated to have a high serum level of CEA, CA125, TPA, ProGRB, Cyfra21-1 and NSE, compared with the normal range. Immunohistochemistry demonstrated higher expression levels of CEA, CA125, TPA, ProGRB, Cyfra21-1 and NSE in lung tumor tissues, compared with the normal range. Results indicated that CT was able to diagnose tumor size for patients with lung cancer. The CEA and CA125 expression levels were associated with CT-diagnosed adenocarcinoma tumor size. Large cell carcinoma tumor size was associated with serum levels of CEA, TPA and ProGRB. Results indicated that Cyfra21-1 and NSE were associated with the squamous cell carcinoma cases, as demonstrated using CT. In conclusion, these results indicated that comprehensive analysis of marker gene detection and CT results may be used to diagnose human lung cancer.

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“…At present, CT is the main tool for target volume delineation of lung cancer radiotherapy, but it cannot correctly distinguish the primary tumor and normal tissue and cannot judge the nature of regional lymph nodes. [ 10 ] Therefore, a more effective imaging method for radiotherapy is desirable.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance (MR) imaging for tumor staging and definition of tumor volumes on radiation treatment planning in nonsmall cell lung cancer

Zhao

et al. 2017

Medicine

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We investigate the impact of magnetic resonance (MR) on the staging and radiotherapy planning for patients with nonsmall cell lung cancer (NSCLC).A total of 24 patients with NSCLC underwent MRI, which was fused with radiotherapy planning CT using rigid registration. Gross tumor volume (GTV) was delineated not only according to CT image alone (GTVCT), but also based on both CT and MR image (GTVCT/MR). For each patient, 2 conformal treatment plans were made according to GTVCT and GTVCT/MR, respectively. Dose-volume histograms (DVH) for lesion and normal organs were generated using both GTVCT and GTVCT/MR treatment plans. All patients were irradiated according to GTVCT/MR plan.Median volume of the GTVCT/MR and GTVCT were 105.42 cm3 and 124.45 cm3, respectively, and the mean value of GTVCT/MR was significantly smaller than that of GTVCT (145.71 ± 145.04 vs 174.30 ± 150.34, P < 0.01). Clinical stage was modified in 9 patients (37.5%). The objective response rate (ORR) was 83.3% and the l-year overall survival (OS) was 87.5%.MR is a useful tool in radiotherapy treatment planning for NSCLC, which improves the definition of tumor volume, reduces organs at risk dose and does not increase the local recurrence rate.

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Diagnosis of Regional Node Metastases in Lung Cancer with Computer-Aided 3D Measurement of the Volume and CT-Attenuation Values of Lymph Nodes

Cited by 12 publications

References 20 publications

Assessment of Sentinel Lymph Node Metastasis in Canine Mammary Gland Tumors Using Computed Tomographic Indirect Lymphography

Assessment of Sentinel Lymph Node Metastasis in Canine Mammary Gland Tumors Using Computed Tomographic Indirect Lymphography

Comprehensive analysis of marker gene detection and computed tomography for the diagnosis of human lung cancer

Magnetic resonance (MR) imaging for tumor staging and definition of tumor volumes on radiation treatment planning in nonsmall cell lung cancer

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