Diagnosis of Sarcoidosis from a Biopsy of a Dilated Mammary Duct

Mason, C H; Yang, Robert Z.; Hamilton, Raynal; Punar, Metin; Shah, Zeeshan Ali; Spigel, Joseph J.; Wang, Jean

doi:10.1080/08998280.2017.11929584

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…La sarcoidosis es una enfermedad granulomatosa sistémica de etiología desconocida que afecta pulmones y ganglios linfáticos, la cual se caracteriza por granulomas en ausencia de necrosis, inflamación extensa y abscesos. La mama está involucrada en menos del 1% de los casos (6) . La granulomatosis de Wegener es una vasculitis que generalmente afecta vías respiratorias, pulmones y riñones.…”

Section: Discussionunclassified

Mastitis granulomatosa idiopática. Reporte de caso

Rondón-Tapia

Torres-Cepeda

2018

Rev peru ginecol obstet.

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La mastitis granulomatosa idiopática es una enfermedad benigna, rara y crónica. Su etiología no está clara; sin embargo, se ha demostrado que la enfermedad se correlaciona con la lactancia, uso de anticonceptivos orales y hasta un componente autoinmune. La presentación característica es la reacción inflamatoria con granulomas no caseificantes. Las características histológicas incluyen signos de inflamación granulomatosa crónica con células gigantes, leucocitos, células epitelioides y macrófagos, así como microabscesos. En el diagnóstico diferencial, todas las causas de cambios granulomatosos deben excluirse antes de realizar el diagnóstico. Debido a su baja frecuencia, es difícil estandarizar y optimizar el tratamiento. Se presenta un caso de mujer de 36 años con nódulos dolorosos en mama derecha. La clínica y los hallazgos del estudio de imágenes llevaron a sospecha de carcinoma. El examen histopatológico reveló inflamación aguda y crónica con infiltración de macrófagos e histiocitos gigantes perivasculares con reacción granulomatosa gigantocelular, sin signos histológicos sugerentes de malignidad y sugestivos de proceso granulomatoso. Las coloraciones para hongos y micobacterias fueron negativas. La paciente fue diagnosticada como mastitis granulomatosa idiopática. El tratamiento consistió en corticosteroides más metotrexato. La paciente se encuentra libre de recurrencia 18 meses después del tratamiento.

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Section: Discussionunclassified

Mastitis granulomatosa idiopática. Reporte de caso

Rondón-Tapia

Torres-Cepeda

2018

Rev peru ginecol obstet.

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“…The workup can ensue after abnormal findings are detected on either a screening mammography, a screening breast ultrasound, or as a result of an incidental finding on chest imaging. These patients typically present without any complaints or breast masses [2,3,9]. Symptomatic patients, on the other hand, usually present because of a self-detected breast mass [10].…”

Section: Clinical Presentationmentioning

confidence: 99%

Sarcoidosis of the Breast

Pluguez-Turull,

Del Toro,

Tjendra

2024

Sarcoidosis - Diagnosis, Research, and Therapy of a Granulomatous Disease

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The clinical manifestation of breast sarcoidosis accounts for <1% of cases of sarcoidosis and typically presents in the setting of already documented systemic involvement. Within the breast, sarcoidosis can often present as a firm palpable mass in young or middle-aged women. On mammography, imaging findings range from small, well-defined round masses to irregular, spiculated masses. Ultrasound most commonly demonstrates an ill-defined hypoechoic mass. As a result, breast sarcoidosis can mimic benign and malignant pathologies such as fat necrosis, fibroadenoma or breast cancer. This variability in imaging appearance represents a diagnostic challenge often culminating in image-guided or surgical biopsy and histological analysis to establish a definitive diagnosis. Ultimately, while breast involvement is uncommon, it accentuates the diverse clinical manifestations of sarcoidosis, which may be clinically suspected and must be adequately evaluated to exclude more significant pathologies.

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“…According to Ojeda and coll., 35 cases of breast sarcoidosis with histological documentation, all in women, were reported in literature from 1921 to 1997 [75]. Our literature search has found 30 other cases to date, also presenting as lumps in the breast [5,72,. Painless breast masses were the main presentation, sometimes associated with skin with an "orange peel" aspect.…”

Section: Sarcoidosismentioning

confidence: 99%

“…Painless breast masses were the main presentation, sometimes associated with skin with an "orange peel" aspect. In some cases, breast involvement was asymptomatic and sarcoidosis had been diagnosed in the context of breast cancer screening as a public health strategy [5,[113][114][115]. Systemic symptoms usually preceded breast localization, whereas breast involvement was the first symptom of sarcoidosis in 11 of these patients.…”

Section: Sarcoidosismentioning

confidence: 99%

“…This group has recently been described in the medical literature and includes a wide range of autoimmune diseases [1][2][3]. Recent case reports are numerous, suggesting that this condition is underdiagnosed or misdiagnosed [1][2][3][4][5]. The clinical spectrum of autoimmune mastitis is broad: while some patients are asymptomatic, others have severe, recurrent breast inflammation, painful nodules, nipple discharge or retraction, and/or lymphadenopathy.…”

Section: Introductionmentioning

confidence: 99%

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Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Goulabchand

Hafidi

Perre

et al. 2020

JCM

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Mastitis frequently affects women of childbearing age. Of all the pathological breast conditions requiring specific management, autoimmune mastitis is in the third position after infection and breast cancer. The aim of this literature review was to make a comprehensive description of autoimmune diseases targeting the mammary gland. Four main histological patterns of autoimmune mastitis are described: (i) lymphocytic infiltrates; (ii) ductal ectasia; (iii) granulomatous mastitis; and (iv) vasculitis. Our literature search found that all types of autoimmune disease may target the mammary gland: organ-specific diseases (diabetes, thyroiditis); connective tissue diseases (such as systemic erythematosus lupus or Sjögren’s syndrome); vasculitides (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, giant cell arteritis, polyarteritis nodosa, Behçet’s disease); granulomatous diseases (sarcoidosis, Crohn’s disease); and IgG4-related disease. Cases of breast-specific autoimmune diseases have also been reported, including idiopathic granulomatous mastitis. These breast-limited inflammatory diseases are sometimes the first symptom of a systemic autoimmune disease. Although autoimmune mastitis is rare, it is probably underdiagnosed or misdiagnosed. Early diagnosis may allow us to detect systemic diseases at an earlier stage, which could help to initiate a prompt, appropriate therapeutic strategy. In case of suspected autoimmune mastitis, we hereby propose a diagnostic pathway and discuss the potential pathophysiological pathways leading to autoimmune breast damage.

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Diagnosis of Sarcoidosis from a Biopsy of a Dilated Mammary Duct

Cited by 4 publications

References 8 publications

Mastitis granulomatosa idiopática. Reporte de caso

Mastitis granulomatosa idiopática. Reporte de caso

Sarcoidosis of the Breast

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

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