Diagnosis of small intestinal bacterial overgrowth in patients with cirrhosis of the liver: poor performance of the glucose breath hydrogen test

Bauer, Tilman; Schwacha, H; Steinbrückner, Bernhard; Brinkmann, Folke; Ditzen, Anette; Kist, Manfred; Blum, Hubert E.

doi:10.1016/s0168-8278(00)80273-1

Cited by 73 publications

(49 citation statements)

References 30 publications

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“…There have been trials using several concentrations of glucose based HBTs in the detection of SIBO. [22][23][24] Among these, 50 g or 75 g of glucose were frequently used. Compared to the 50 g of glucose, 75 g of glucose is thought to explain distal small bowel SIBO compared to the 50 g of glucose.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Fructose Malabsorption in Patients With Irritable Bowel Syndrome After Excluding Small Intestinal Bacterial Overgrowth

Jung

Seo

Cho

et al. 2018

J Neurogastroenterol Motil

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Background/AimsFructose malabsorption (FM) mimics symptoms of irritable bowel syndrome (IBS), and its prevalence has increased. Diagnosing FM in IBS is challenging because of its overlap with small intestinal bacterial overgrowth (SIBO). We assessed the prevalence of FM by comparing patients with IBS with asymptomatic control individuals after excluding SIBO using the glucose hydrogen breath test (HBT). MethodsPatients diagnosed with IBS and asymptomatic control individuals were enrolled prospectively. Dietary habits were assessed with the Food Frequency Questionnaire. After excluding SIBO, participants underwent HBTs with both 15 g and 25 g of fructose. Results Thirty 040). Analysis of the Food FrequencyQuestionnaire responses showed no significant differences between the 2 groups in dietary intake, although patients with IBS showed a significantly higher mean fiber intake than controls (21.24 ± 11.35 g vs 15.87 ± 7.07 g, respectively, P = 0.040). ConclusionsThe 25-g fructose HBT identified FM in a significantly higher percentage of SIBO-negative patients with IBS than in asymptomatic control individuals, suggesting that FM may correlate with IBS. Education regarding dietary control of foods containing fructose may be useful for the management of patients with IBS. (J Neurogastroenterol Motil 2018;24:307-316)

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Section: Discussionmentioning

confidence: 99%

Prevalence of Fructose Malabsorption in Patients With Irritable Bowel Syndrome After Excluding Small Intestinal Bacterial Overgrowth

Jung

Seo

Cho

et al. 2018

J Neurogastroenterol Motil

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“…Breath hydrogen is an important, clinically relevant parameter used as an indicator of lactose intolerance [1][2][3], fructose malabsorption [4][5][6][7][8], microbial activity [9], bacterial growth [10][11][12], fibromyalgia [13], diabetic gastroparesis [14][15][16], and neonatal necrotizing enterocolitis [17][18][19][20][21]. The pathogenesis of neonatal necrotizing enterocolitis (NEC), a devastating disease due to bacterial fermentation which causes necrosis of the intestinal walls of preterm infants, results in the production of hydrogen gas which accumulates as bubbles in the sub-mucosal area of the bowel wall as shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

A Sentinel Sensor Network for Hydrogen Sensing

Grimes

Ong

Varghese

et al. 2003

Sensors

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A wireless sensor network is presented for in-situ monitoring of atmospheric hydrogen concentration. The hydrogen sensor network consists of multiple sensor nodes, equipped with titania nanotube hydrogen sensors, distributed throughout the area of interest; each node is both sensor, and data-relay station that enables extended wide area monitoring without a consequent increase of node power and thus node size. The hydrogen sensor is fabricated from a sheet of highly ordered titania nanotubes, made by anodization of a titanium thick film, to which platinum electrodes are connected. The electrical resistance of the hydrogen sensor varies from 245 Ω at 500 ppm hydrogen, to 10.23 kΩ at 0 ppm hydrogen (pure nitrogen environment). The measured resistance is converted to voltage, 0.049 V at 500 ppm to 2.046 V at 0 ppm, by interface circuitry. The microcontroller of the sensor node digitizes the voltage and transmits the digital information, using intermediate nodes as relays, to a host node that downloads measurement data to a computer for display. 70This paper describes the design and operation of the sensor network, the titania nanotube hydrogen sensors with an apparent low level resolution of approximately 0.05 ppm, and their integration in one widely useful device.

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“…H 2 breath tests can be used to diagnose clinical disorders of digestion and absorption, including lactase deficiency and other disorders of di-and monosaccharide malabsorption, starch malabsorption, and small-bowel bacterial overgrowth. Breath H 2 testing has repeatedly been demonstrated to be the most accurate indirect indicator of lactase deficiency, and breath H 2 measurements have been widely applied in digestion studies on the entire spectrum of dietary carbohydrates (82)(83)(84).…”

Section: Gastroenteric Diseasesmentioning

confidence: 99%

Breath Analysis: Potential for Clinical Diagnosis and Exposure Assessment

Cao¹,

Duan²

2006

Clinical Chemistry

364

238

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Breath tests are among the least invasive methods available for clinical diagnosis, disease state monitoring, and environmental exposure assessment. In recent years, interest in breath analysis for clinical purposes has increased. This review is intended to describe the potential applications of breath tests, including clinical diagnosis of diseases and monitoring of environmental pollutant exposure, with emphasis on oxidative stress, lung diseases, metabolic disorder, gastroenteric diseases, and some other applications. The application of breath tests in assessment of exposure to volatile organic compounds is also addressed. Finally, both the advantages and limitations of breath analysis are summarized and discussed.

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Diagnosis of small intestinal bacterial overgrowth in patients with cirrhosis of the liver: poor performance of the glucose breath hydrogen test

Cited by 73 publications

References 30 publications

Prevalence of Fructose Malabsorption in Patients With Irritable Bowel Syndrome After Excluding Small Intestinal Bacterial Overgrowth

Prevalence of Fructose Malabsorption in Patients With Irritable Bowel Syndrome After Excluding Small Intestinal Bacterial Overgrowth

A Sentinel Sensor Network for Hydrogen Sensing

Breath Analysis: Potential for Clinical Diagnosis and Exposure Assessment

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