Diagnosis of Streptococcal Pharyngitis and Rheumatic Fever

Taranta, Angelo; Moody, Max D.

doi:10.1016/s0031-3955(16)32527-5

Cited by 26 publications

(5 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the ability of certain strains of streptococci to haemolyse red blood cells (beta-haemolysis) 10-12 was first observed as early as 1895 13-14 , it was not until 1938 that Streptolysin S (SLS) was identified as being one of two distinct toxins responsible for the ability of GAS to lyse mammalian erythrocytes 15 ; the other being the unrelated, large cholesterol-dependent, oxygen-sensitive toxin, Streptolysin O (SLO) 16-17 . Although SLS has been subject to rigorous investigation (Box 1), isolation of the mature SLS toxin and elucidation of its molecular structure has proven elusive 18 .…”

Section: Introductionmentioning

confidence: 99%

Streptolysin S-like virulence factors: the continuing sagA

et al. 2011

View full text Add to dashboard Cite

Streptolysin S (SLS) is a potent cytolytic toxin and virulence factor produced by nearly all Streptococcus pyogenes strains. Despite a 100-year history of research on this toxin, it has only recently been established that SLS represents the archetypal example of an extended family of post-translationally modified virulence factors also produced by some other streptococci and Gram-positive pathogens, such as Listeria monocytogenes and Clostridium botulinum. In this Review we describe the identification, genetics, biochemistry and various functions of SLS. We also discuss the shared features of the virulence-associated SLS-like peptides, as well as their place within the rapidly expanding family of thiazole/oxazole-modified microcins (TOMMs).

show abstract

Section: Introductionmentioning

confidence: 99%

Streptolysin S-like virulence factors: the continuing sagA

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Of interest in recent years has been the role these organisms have played in causing opportunistic infections (1,10,11). Although presumptive identification of group A streptococci may be provided with reasonable accuracy by the selective inhibition of these strains by a 0.02or 0.04-unit bacitracin disk (15), serological grouping is necessary for definitive identification of group A and other fl-hemolytic streptococci.…”

Section: Discussionmentioning

confidence: 99%

Microbiological Study of Streptococcal Bacteremia

Horstmeier¹,

Washington²

1973

Applied Microbiology

View full text Add to dashboard Cite

During a 2.5-year study, streptococci were isolated from 280 patients (19% of those with bacteremia). Of this number, 54 had group D streptococci (45 were enterococci), 218 had a-or y-hemolytic nongroup D streptococci, and 49 had fl-hemolytic streptococci. With the increased frequency in recent years of gram-negative bacillemia, there has been relatively less attention devoted to streptococcal bacteremia. Recent data obtained at the

show abstract

“…Colonies showing apparent beta-hemolysis in culture B (pour plate) were studied under x 15 magnification. The edges of the colonies were examined for the presence or absence of intact erythrocytes as shown in the figures in Taranta and Moody's article (4).…”

Section: Methodsmentioning

confidence: 99%

“…Although wide-zone, alpha-hemolytic streptococci are potential sources of false-positive throat cultures, the magnitude of this problem was unknown (4). The relationship of group A beta-hemolytic streptococcal pharyngitis to the later occurrence of rheumatic fever is well established, but infections with alpha-hemolytic streptococci and beta-hemolytic streptococci other than group A do not cause this complication.…”

mentioning

confidence: 99%

Absence of wide-zone, alpha-hemolytic streptococci in children with pharyngitis

Saitz¹,

Stratigos²

1976

J Clin Microbiol

View full text Add to dashboard Cite

Wide-zone, alpha-hemolytic streptococci are potential sources of false-positive throat cultures since they can be misinterpreted as beta-hemolytic streptococci. However, quantitative information regarding their occurrence in sick children was not available. Throat swabs from 312 children with pharyngitis were processed conventionally and also with pour-plate methods and examination of the positive cultures under magnification. One-third of all cultures were positive for beta-hemolytic streptococci. There were no significant differences in the number of positive cultures among or between the different methods. Wide-zone, alpha-streptococci were found in none of the cultures. Therefore, they are unlikely to be a common cause of false-positive cultures in children with pharyngitis.

show abstract

Diagnosis of Streptococcal Pharyngitis and Rheumatic Fever

Cited by 26 publications

References 52 publications

Streptolysin S-like virulence factors: the continuing sagA

Streptolysin S-like virulence factors: the continuing sagA

Microbiological Study of Streptococcal Bacteremia

Absence of wide-zone, alpha-hemolytic streptococci in children with pharyngitis

Contact Info

Product

Resources

About