Diagnosis of Symptomatic Lung Cancer

Andersen, Howard A.; Prakash, Udaya B. S.

doi:10.1055/s-2007-1012192

Cited by 14 publications

(7 citation statements)

References 39 publications

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“…Larger pulmonary lesions, central tumors, or tumors with an endobronchial component are more likely to result in pulmonary symptoms, including cough, on symptoms and signs that refl ect local effects from the primary tumor, extension of disease in the thoracic cavity, radiographic correlates, distant metastatic disease, and fi ndings suggestive of paraneoplastic syndromes ( Fig 3 ). [2][3][4][5][6][7][8][9][10] Figure 2.…”

Section: Symptoms Related To the Primary Tumormentioning

confidence: 99%

“…dyspnea, chest pain, and hemoptysis. [2][3][4][5][6][7] Of these, cough is the most common presentation and may result from endobronchial irritation, parenchymal infi ltration, or postobstructive pneumonia. Recurrent pneumonia in the same anatomic distribution or relapsing acute exacerbations of COPD should raise concern for neoplasm.…”

Section: E125smentioning

confidence: 99%

“…The most common sites of spread are the hilar and mediastinal lymph nodes. Although nodal metastases rarely cause symptoms, bulky adenopathy in the hila can cause extrinsic airway Modifi ed from Andersen et al, 2 Grippi, 3 Hyde and Hyde, 4 Cromartie et al, 5 Karsell and McDougall, 6 and the American Thoracic Society and European Respiratory Society. 7 SVC 5 superior vena cava.…”

Section: Symptoms and Signs Of Intrathoracic Spreadmentioning

confidence: 99%

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Clinical and Organizational Factors in the Initial Evaluation of Patients With Lung Cancer

Ost

Yeung

Tanoue

et al. 2013

Chest

156

109

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Section: Symptoms Related To the Primary Tumormentioning

confidence: 99%

Section: E125smentioning

confidence: 99%

Section: Symptoms and Signs Of Intrathoracic Spreadmentioning

confidence: 99%

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Clinical and Organizational Factors in the Initial Evaluation of Patients With Lung Cancer

Ost

Yeung

Tanoue

et al. 2013

Chest

156

109

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“…Calculations of the effects of buffers on H' diffusion to a membrane channel3' applied to experimental conditions typical for our studies (100 mM buffer) enhance the H' current by less than 50%.32 The second unknown is the capture radius, ro, which has a macroscopic definiti~n?~ but on the scale of a single channel is simply an effective parameter. 34 In the absence of buffer, gramicidin channels conducting H' current in this mid-range of pH have ro = 0.87 A;29 this value was used to draw the line in Fig. 1.…”

Section: ( I ) Saturation At Low P Hmentioning

confidence: 99%

An Electrophysiological Comparison of Voltage‐Gated Proton Channels, Other Ion Channels, and Other Proton Channels

DeCoursey

Cherny

1999

Israel Journal of Chemistry

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Abstract. Voltage-gated proton selective channels occupy an ill-defined region between "normal" ion channels and a variety of proton-conducting pathways inside proteins, including, but not limited to, membrane-bound proteins. Voltage-gated H+ channels closely resemble other voltage-gated ion channels in their voltage-and time-dependent gating, but differ in their extreme selectivity, their miniscule singlechannel conductance, and the high activation enthalpy for conduction. Furthermore, in contrast with the "multiple occupancy" hypothesized to account for aspects of permeation through other ion channels, it seems unlikely that H' channels can be occupied by more than one proton at a time. Voltage-gated H+ channels functionally resemble other proton-conducting pathways in proteins, but until their structure has been determined, this similarity will remain speculative. The present restriction to functional measurements is less of a handicap than might be expected-the history of ion channel research shows that deductions based on electrophysiological measurements often closely predict the eventually determined structure. Existing evidence supports the idea that protons permeate the membrane through voltage-gated H+ channels by hopping across a hydrogen-bonded chain that consists of at least some amino acid side groups in addition to water molecules.

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“…Por último, hay que tener en cuenta que, si el SP no se diagnostica y controla, puede ser una amenaza para la vida del enfermo. Entre un 7-15% de las neoplasias se manifiestan en algún momento de su evolución por alguna forma de SP (3), y el porcentaje en el Ca de pulmón alcanza al 10% de los pacientes e involucra a muchos órganos y sistemas (4,5). En la tabla I se exponen los más frecuentes (2).…”

Section: Introductionunclassified

Cáncer de pulmón y síndromes paraneoplásicos

Gámez¹,

Lucas²,

Rodríguez

2001

An. Med. Interna (Madrid)

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RESUMENEn aquellos pacientes con una neoplasia, es relativamente común la aparición de un síndrome paraneoplásico (SP) que, en algunos de los casos, puede ser la manifestación clínica inicial. Entre los tumores malignos, se observa con mayor frecuencia en el cáncer de pulmón; este hecho es importante tenerlo en cuenta, sobre todo ante la presencia de un SP neurológico o endocrino que puede facilitar un diagnóstico más precoz y, en determinados casos, un tratamiento más eficaz de la enfermedad de base. La evolución del SP suele ser paralela a la del tumor subyacente, sin embargo, su manejo requiere, no sólo el control de la neoplasia, sino, además adoptar medidas terapéuticas específicas, ya que la evolución del SP, como ocurre en la hipercalcemia maligna, puede amenazar la vida del paciente.Se revisan los SP neurológicos y endocrinos más importantes asociados con el cáncer de pulmón.PALABRAS CLAVE: Cáncer de pulmón. Síndrome paraneoplásico. Síndrome de Eaton-Lambert. Neuropatía sensorial subaguda. Encefalitis límbica. Secreción inadecuada de ADH. Síndrome de Cushing. Hipercalcemia maligna. ABSTRACTParaneoplastic syndromes (PNS) are a relatively common manifestation of cancer, and in some cases they may be the first symptom. Lung cancer has the highest incidence of paraneoplastic syndrome. This fact is important considering a non explained endocrinological and neurological syndrome, it may facilitate a prompt diagnosis, and in some cases an adequate treatment. PNS evolution seems to be parallel to the subjacent cancer. PNS management requires specific measures, because in some cases, it may compromise the patient life.Neurological and endocrinological PNS associated to lung cancer are revised, and diagnosis and treatment of them are updated.

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Diagnosis of Symptomatic Lung Cancer

Cited by 14 publications

References 39 publications

Clinical and Organizational Factors in the Initial Evaluation of Patients With Lung Cancer

Clinical and Organizational Factors in the Initial Evaluation of Patients With Lung Cancer

An Electrophysiological Comparison of Voltage‐Gated Proton Channels, Other Ion Channels, and Other Proton Channels

Cáncer de pulmón y síndromes paraneoplásicos

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