Diagnosis of syphilis: Clinical and laboratory problems

Lautenschlager, Stephan

doi:10.1111/j.1610-0387.2006.06072.x

Cited by 54 publications

(61 citation statements)

References 63 publications

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“…Some of these events were reported by our patient, additionally to hair, eyebrows, and eyelashes loss, which have been reported in about 5-6% of the patients with syphilis 5 . In addition, approximately 75% of patients with secondary syphilis develop skin manifestations 16 . Its most common presentation is called syphilitic roseola which is characterized by symmetrical, asymptomatic, and pink or red macules that last about two weeks and usually affect the trunk and extremities 5,14 .…”

Section: Discussionmentioning

confidence: 99%

Reemerging syphilis

Santos¹,

Bastos²,

Valente³

et al. 2017

J Oral Diag

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Section: Discussionmentioning

confidence: 99%

Reemerging syphilis

Santos¹,

Bastos²,

Valente³

et al. 2017

J Oral Diag

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“…Various oral manifestations can be of diagnostic importance and are present in one-third to one-half of patients (12) . The diagnosis of secondary stage can be performed by specific and non-specific serological tests (8,11,12) . Non-specific tests, such as VDRL, are the most common diagnostic tests used to diagnose syphilis and can be useful for screening large numbers of patients (8,12) .…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of secondary stage can be performed by specific and non-specific serological tests (8,11,12) . Non-specific tests, such as VDRL, are the most common diagnostic tests used to diagnose syphilis and can be useful for screening large numbers of patients (8,12) . VDRL becomes positive in 4 to 8 weeks after acquiring the infection and the sensitivity approaches 100% in secondary syphilis due to the high antibody titers (8) .…”

Section: Discussionmentioning

confidence: 99%

“…It occurs mainly in HIV positive patients that may present typical or atypical oral lesions (7) . A nontreponemal serologic test, such as Venereal Disease Research Laboratory (VDRL) test, is accepted as an effective testing strategy for detecting syphilis, although false-negative reaction can occur, particularly in HIV positive individuals, delayed diagnosis or misdiagnosis of syphilis occurs frequently (6,8,9) . Sometimes, false-negative specific antitreponemal antibodies, such as Fluorescent Treponemal Antibody Absorption (FTA-ABS), can also occur.…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis of secondary syphilis through oral lesions in two patients with negative serology: case reports

Santos¹,

Picciani²,

Cunha³

et al. 2015

J Bras Doenças Sex Transm

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Syphilis is a sexually transmitted infection, and oral lesion can be the first manifestation. The serology test, such as Venereal Disease Research Laboratory test, is accepted as an effective testing strategy for detecting syphilis, although false-negative reaction can occur, and oral lesions may be pivotal to achieve the diagnosis. We report two cases of seronegative secondary syphilis, a human immunodeficiency virus positive patient and a no HIV positive patient, whose histopathological exams were pivotal to achieve the diagnosis of syphilis. The serology may be negative in secondary syphilis and the oral lesions may represent the unique method to diagnostic. Keywords: oral lesion; syphilis; HIV; diagnosis. RESUMOA sífilis é uma doença sexualmente transmissível, e a lesão oral pode representar sua primeira manifestação. Testes sorológicos, como Venereal Disease Research Laboratory, são rotineiramente utilizados para detecção de sífilis, entretanto, em alguns casos, podem ocorrer resultados falso-negativos. Nesses casos, as lesões orais são essenciais para o diagnóstico. Relatamos dois casos de sífilis secundária com sorologia negativa, em um paciente HIV positivo e um paciente HIV negativo, que obtiveram o diagnóstico de sífilis a partir do exame histopatológico das lesões orais. Os testes sorológicos podem ser negativos na sífilis secundária, e as lesões orais podem representar o único método diagnóstico.

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“…Despite the introduction of penicillin in the mid-20th century it has been impossible to eradicate this disease. Its incidence has increased in many parts of the world, and its resurgence is associated with, among other factors, the oral sex without protection, which seems to be potentially linked to the increase in the transmission and incidence of the disease (12)(13)(14) . The objectives of this study were to report a case of syphilitic chancre in the oral cavity and the importance of early diagnosis.…”

Section: Introductionmentioning

confidence: 99%