Diagnosis of the leukemic phase of ALK-positive anaplastic large cell lymphoma by immunohistochemistry on cell block prepared from peripheral blood buffy coat

Kundoo, Aditi; Sethy, Madhusmita; Sable, Mukund; Mishra, Pritinanda; Panigrahi, Asuthosh; Adhya, Amit Kumar

doi:10.4103/ijpm.ijpm_433_19

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…To the best of our knowledge, only one case report has been published describing the diagnosis of SC-ALCL aided by CB prepared from peripheral blood, but that case also included a cutaneous nodule biopsy. 7 Ours is the first report of a case to be diagnosed using only peripheral blood. Immunostaining with a CB of peripheral blood enabled confirmation of ALK-and CD30-positivity in large cells, which are difficult to detect with flow cytometry.…”

Section: Discussionmentioning

confidence: 93%

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Cytological examination of peripheral blood cell block to diagnose small cell variant ALK‐positive anaplastic large cell lymphoma

et al. 2023

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Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK+ ALCL) is characterised by large lymphocyte-like cells with abundant cytoplasm and variable-shaped nuclei, often resembling horseshoes or kidneys. These cells have a specific genetic translocation involving the ALK gene and are positive for ALK and CD30 by immunohistochemistry. 1 In children, ALK+ ALCL is the most common subtype of T-cell lymphoma, accounting for 10%-30% of lymphomas. ALK+ ALCL exhibits a wide range of morphological patterns, with the common variant comprising 60% of cases, followed by lymphohistiocytic (10%), small-cell (5%-10%), and Hodgkin-like (3%) variants. 2 In small cell variant ALCL (SC-ALCL), large hallmark cells are few with the preponderance being small-to medium-sized tumour cells.Tumour cells in peripheral blood indicate the leukaemic phase, which is associated with poor prognosis. Among the morphological variants, patients with SC-ALCL often show the leukaemic phase, thus accurate and prompt diagnosis is essential for effective treatment. 3 How to cite this article: Shimaguchi C, Mizuguchi K, Fujita K, Shimoda T, Ikeda H. Cytological examination of peripheral blood cell block to diagnose small cell variant ALK-positive anaplastic large cell lymphoma.

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Section: Discussionmentioning

confidence: 93%

“…To the best of our knowledge, only one case report has been published describing the diagnosis of SC‐ALCL aided by CB prepared from peripheral blood, but that case also included a cutaneous nodule biopsy 7 . Ours is the first report of a case to be diagnosed using only peripheral blood.…”

Section: Discussionmentioning

confidence: 96%

Cytological examination of peripheral blood cell block to diagnose small cell variant ALK‐positive anaplastic large cell lymphoma

et al. 2023

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“…Although ALK-positive ALCL cases have a relatively good outcome, the small-cell leukemic variant is -irrespective of ALK-translocation status- an aggressive disease. A total of 35 cases of leukaemic, small cell variant of ALK-positive ALCLs have been previously reported [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ] ( Table 1 ) with limited follow-up time (from 1 to 63 months) in the surviving patients. All evidence points to an aggressive disease with a median overall survival of 12 months and a high tendency for central nervous system recurrences.…”

Section: Case Reportmentioning

confidence: 99%

Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival

Santonja,

Morillo-Giles,

Prieto-Pareja

et al. 2023

Medicina

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Anaplastic large cell lymphoma (ALCL) with leukaemic presentation (either ab initio or along the course of the disease) has been rarely reported. Irrespective of ALK expression in the neoplastic cells, it features a dismal prognosis. We report a rare case of leukaemic, small cell variant ALK-positive ALCL with 9-year survival in a young woman who was treated upfront with corticosteroids and standard chemotherapy, and review thoroughly the previously published cases. Such an unexpected, good outcome hints at the existence of different clinical subgroups in the leukaemic variant of ALK-positive ALCL.

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Diagnosis of the leukemic phase of ALK-positive anaplastic large cell lymphoma by immunohistochemistry on cell block prepared from peripheral blood buffy coat

Cited by 2 publications

References 12 publications

Cytological examination of peripheral blood cell block to diagnose small cell variant ALK‐positive anaplastic large cell lymphoma

Cytological examination of peripheral blood cell block to diagnose small cell variant ALK‐positive anaplastic large cell lymphoma

Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival

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