Diagnosis, Treatment, and Reporting of Adverse Effects of Transfusion

Torres, Richard; Kenney, Barton; Tormey, Christopher A.

doi:10.1309/lm3naabjjk1hnyfu

Cited by 26 publications

(32 citation statements)

References 55 publications

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“…congestive heart failure, cardiac arrhythmias, hypertension), suggest potential importance of underlying immunity among the elderly for FNHTR occurrence, which needs further clinical evaluations. In support of the literature, our study also suggests FNHTR to be one of the most frequent transfusion‐related adverse events among the elderly . As such, physicians should be aware of FNHTR occurrence among the elderly, which results in patient discomfort and therapeutic intervention.…”

Section: Discussionsupporting

confidence: 82%

Febrile non‐haemolytic transfusion reaction occurrence and potential risk factors among the U.S. elderly transfused in the inpatient setting, as recorded in Medicare databases during 2011–2012

et al. 2014

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Section: Discussionsupporting

confidence: 82%

Febrile non‐haemolytic transfusion reaction occurrence and potential risk factors among the U.S. elderly transfused in the inpatient setting, as recorded in Medicare databases during 2011–2012

et al. 2014

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“…The high incidence of FNHTR is vindicable as many earlier studies were in line with the present study . Regardless of years of observational studies and in vitro experiments, the correct mechanisms underlying FNHTRs remain vague . Other AEs that were found during study include rashes, vomiting, headache, body ache, urticaria, loin pain, swelling and fever.…”

Section: Discussionmentioning

confidence: 99%

“…Most of these AEs result as a consequence of allergic reactions. On display of signs or symptoms steady with a mild allergic reaction, blood product infusion should be discontinued .…”

Section: Discussionmentioning

confidence: 99%

Haemovigilance study at a tertiary care hospital in the north‐east of India

Somagari

Sriram

Rachamalla

et al. 2015

ISBT Science Series

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Background and Aim Blood transfusion is a frequent and integral part of critical patient care. Even though life-saving, it could be occasionally risky and result in a spectrum of adverse events. Haemovigilance programme is a standard set-up to monitor the entire transfusion chain, evaluate and analyse the data to improve patient's safety. The haemovigilance programme has been established in India very recently. We report the implemented haemovigilance programme at a tertiary care hospital in the north-east of India.Results A total of 51 000 blood components were transfused and 106 adverse events reported during the period of the study. The major stakes of adverse events were febrile non-haemolytic transfusion reactions (50%), pruritus (17Á92%) and rigour/chills (11Á32%). All the adverse events were found to be Grade 1 (non-severe) type, and there were no severe or life-threatening adverse events.

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“…These studies, however, do not address other causes of blood product discard, such as units not completed due to transfusion reactions. Although many reactions necessitate stopping the transfusion with ultimate discard of the involved blood product, there is a notable exception, the case of non‐severe allergic transfusion reactions (Sazama et al ., ; Torres et al ., ).…”

mentioning

confidence: 97%

Blood product and laboratory resource wastage in non‐severe allergic transfusion reactions: an opportunity for improvement

Kasim

Aldarweesh

2019

Transfusion Medicine

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SUMMARY Objective To evaluate the degree of blood product and technical resources wasted as a result of allergic transfusion reactions. Background Allergic reactions are common, and most are non‐severe with rash, urticaria, or pruritus. Management includes treatment of symptoms and completion of transfusion. A quality review demonstrated that 30% of transfusion reaction work‐ups at our institution were allergic. This raised the concern of product wastage and unnecessary utilisation of laboratory resources. Methods We conducted a retrospective study of allergic reactions, including type of product implicated, volume of products transfused and discarded, the severity of reaction, the use of medications, the incidence of symptom resolution and the rate of repeat transfusion after the allergic event. Results Of 179 allergic reactions, non‐severe reactions were reported in 75%. Non‐severe reactions were associated with red blood cell, whereas most severe reactions were associated with platelets. Few cases had premedication; however, 83% of reactions were treated once symptoms developed, and 96% resolved. Of transfusions, 61% were stopped because of symptoms before the transfusion was completed. Of patients with non‐severe reactions and transfusions that were not completed, 36% were transfused again within 48 h, representing 16% of all allergic reactions. Conclusion Allergic reactions resulted in partial transfusion of the prescribed product in just over half of the cases reviewed. Most of these reactions were non‐severe, resolved with treatment and could have been completed, thus representing wastage of both blood products and the expense of the reaction evaluation. Educational efforts to eliminate/minimise this waste are in development.

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Diagnosis, Treatment, and Reporting of Adverse Effects of Transfusion

Cited by 26 publications

References 55 publications

Febrile non‐haemolytic transfusion reaction occurrence and potential risk factors among the U.S. elderly transfused in the inpatient setting, as recorded in Medicare databases during 2011–2012

Febrile non‐haemolytic transfusion reaction occurrence and potential risk factors among the U.S. elderly transfused in the inpatient setting, as recorded in Medicare databases during 2011–2012

Haemovigilance study at a tertiary care hospital in the north‐east of India

Blood product and laboratory resource wastage in non‐severe allergic transfusion reactions: an opportunity for improvement

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