Febrile non‐haemolytic transfusion reaction occurrence and potential risk factors among the <scp>U</scp>.<scp>S</scp>. elderly transfused in the inpatient setting, as recorded in <scp>M</scp>edicare databases during 2011–2012

Menis, Mikhail; Forshee, Richard A.; Anderson, Steven A.; McKean, Stephen; Gondalia, Rahul; Warnock, Rob; Johnson, Chris; Mintz, Paul D.; Worrall, Chris; Kelman, Jeffrey A.; Izurieta, Héctor S.

doi:10.1111/vox.12215

Cited by 28 publications

(22 citation statements)

References 38 publications

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“…In general, rates of FNHTR were lower in leucoreduced versus non‐leucoreduced products within the same population (Table ) . With prospective surveillance, the pooled rate of FNHTR was 1191/100 000 units or one in every 84 units; this compares with one case in 3885 RBC units from haemovigilance.…”

Section: Resultsmentioning

confidence: 96%

Haemovigilance of reactions associated with red blood cell transfusion: comparison across 17 Countries

2015

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Section: Resultsmentioning

confidence: 96%

Haemovigilance of reactions associated with red blood cell transfusion: comparison across 17 Countries

2015

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“…Nonetheless, FNHTRs caused by RBC were likely to appear after the first transfusion . Another report indicated that the incidence of FNHTRs increased as the frequency of transfusions increased . Therefore, controversy regarding FNHTRs still exists.…”

Section: Discussionmentioning

confidence: 99%

Analysis of clinical presentations of allergic transfusion reactions and febrile non‐haemolytic transfusion reactions in paediatric patients

et al. 2019

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Background and objectives Like adults, children can have allergic transfusion reactions (ATRs) and febrile non-haemolytic transfusion reactions (FNHTRs). But published information about the incidence of paediatric ATR and FNHTR is scarce.Materials and methods This retrospective study was conducted from April 2002 to June 2018 on children who had ATRs and/or FNHTRs to platelet (PLT), red blood cell (RBC) or washed PLT/RBC concentrate transfusions. We analysed ATR/ FNHTR clinical presentations, such as severity, time of occurrence and other features when they occurred.Results During the study, 2742 children received 23 444 bags of PLT and RBC concentrate (including washed products). ATRs occurred in 100 cases (3Á6% of total patients), caused by 201 products (0Á9% of total products). In contrast, 28 patients (1Á0% of total patients) had 42 FNHTRs caused by 42 products (0Á2% of total products). Upon analysis of cases with detailed clinical information, the median onset time for ATRs and FNHTRs was 2Á0 h after the start of transfusion. Of the 40% of ATRs that necessitated the discontinuation of blood transfusions, 10% escalated to anaphylaxis. Compared with minor ATRs, anaphylaxis tended to develop quickly. Moreover, 96% of patients with FNHTRs had a fever less than 39°C. There were no associations between blood product types and numbers or occurrence patterns of these reactions. ConclusionThe occurrence of ATRs and FNHTRs in children was variable, although there are common features such as severity and time of occurrence.

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“…It is interesting to note that Menis et al . observed in their study that the incidence of FNHTR decreased with age (48·2 per 100 000 stays in patients aged 85 years or over versus 63·8 per 100 000 stays in patients aged 65–69 years).…”

Section: Discussionmentioning

confidence: 87%

Adverse transfusion reactions in patients with aplastic anaemia or myelodysplastic syndromes

et al. 2019

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Background and Objectives Patients with aplastic anaemia or myelodysplastic syndromes frequently receive transfusions in an attempt to correct anaemia and/ or thrombocytopenia, putting them at risk of adverse transfusion reactions. The aim of this study is to evaluate the incidence and the types of adverse transfusion reactions in these patients. Materials and MethodsAdverse transfusion reaction reported in transfused patients with aplastic anaemia or myelodysplastic syndromes from all the hospitals in the Auvergne-Rhône-Alpes region of France were extracted from the national haemovigilance database system and analysed. The types of adverse transfusion reactions, their incidence, their severity, the blood component involved and its imputability were evaluated.Results From 1 January 2010 to 30 June 2016, 7174 adverse transfusion reactions were reported. Seventy adverse transfusion reactions (0Á9%) were reported in patients with aplastic anaemia and 193 (2Á7%) in patients with myelodysplastic syndromes. Febrile non-haemolytic transfusion reaction was the most common reaction both aplastic anaemia (23 cases, 33Á0%) and myelodysplastic syndrome (56 cases, 29Á0%). Post-transfusion red blood cell alloimmunization was also high in both these groups (17Á1% in patients with aplastic anaemia and 22Á3% in patients with myelodysplastic syndrome) frequently involving anti-JK1 (Jk a ) specificity.Conclusion Febrile non-haemolytic transfusion reaction was the most common adverse transfusion reaction in patients with aplastic anaemia or myelodysplastic syndromes who received transfusions. Post-transfusion red blood cell alloimmunization was also observed frequently, but the use of RH-KEL 1 (Rhesus-Kell)matched red blood cell concentrates reduces this risk.

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Febrile non‐haemolytic transfusion reaction occurrence and potential risk factors among the U.S. elderly transfused in the inpatient setting, as recorded in Medicare databases during 2011–2012

Cited by 28 publications

References 38 publications

Haemovigilance of reactions associated with red blood cell transfusion: comparison across 17 Countries

Haemovigilance of reactions associated with red blood cell transfusion: comparison across 17 Countries

Analysis of clinical presentations of allergic transfusion reactions and febrile non‐haemolytic transfusion reactions in paediatric patients

Adverse transfusion reactions in patients with aplastic anaemia or myelodysplastic syndromes

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