Diagnostic accuracy of coronary CT angiography performed in 100 consecutive patients with coronary stents using a whole-organ high-definition CT scanner

Andreini, Daniele; Mushtaq, Saima; Conte, Edoardo; Guglielmo, Marco; Mancini, Maria Elisabetta; Annoni, Andrea; Baggiano, Andrea; Formenti, Alberto; Montorsi, Piero; Magatelli, Marco; Odoardo, Luca Di; Melotti, Eleonora; Resta, Marta; Muscogiuri, Giuseppe; Fiorentini, Cesare; Bartorelli, Antonio L.; Pepi, Mauro

doi:10.1016/j.ijcard.2018.09.010

Cited by 26 publications

(18 citation statements)

References 21 publications

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“…Cardiac CT offers an accurate anatomical evaluation of CAD comparable to ICA 5 . For this reason, coronary CT angiography has rapidly become an alternative to ICA for CAD assessment and the new generation scanners are now considered to have high diagnostic performance for detection of significant coronary stenosis in different populations 2 . The low cost and high sensitivity of cardiac CT makes it the non-invasive test of choice in the evaluation of stable angina 2 .…”

Section: Discussionmentioning

confidence: 99%

“…For this reason, coronary CT angiography has rapidly become an alternative to ICA for CAD assessment and the new generation scanners are now considered to have high diagnostic performance for detection of significant coronary stenosis in different populations 2 . The low cost and high sensitivity of cardiac CT makes it the non-invasive test of choice in the evaluation of stable angina 2 . This has now been ratified in national guidelines with National Institute for Health and Care Excellences (NICE) recommending cardiac CT as the first-line investigation for all patients presenting with angina pectoris in whom CAD is therefore suspected 1 .…”

Section: Discussionmentioning

confidence: 99%

“…The update edition of the National Institute for Health and Care Excellence (NICE) guidelines state that cardiac CT is the non-invasive test of choice in the evaluation of patients with stable angina in order to rule out CAD 1 . Also, patients with known CAD who previously had percutaneous coronary intervention might benefit from cardiac CT in case of recurrent angina or diagnostic findings indicating that a ‘de novo’ stenosis might have occurred 2 . Noteworthy, patients with suspected or known CAD often have a high lung cancer risk as well 3 .…”

Section: Introductionmentioning

confidence: 99%

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Concomitant screening of coronary artery disease and lung cancer with a new ultrafast-low-dose Computed Tomography protocol: A pilot randomised trial

Gaudio

Tanzilli

Mei

et al. 2019

Sci Rep

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We performed a pilot randomised study to assess the feasibility and radiation exposure of a new computed tomography (CT) protocol that allows screening of both coronary artery disease (CAD) and lung cancer. Current or former heavy smokers at high lung cancer risk with indication to cardiac CT for suspected or known CAD were randomised to undergo concomitant CT evaluation of either cardiac or thoracic area or cardiac CT only. Out of 129 subjects deemed eligible for the study, 110 agreed to participate and were randomised to simultaneous cardiac and lung CT (Gr.A; n = 55) or cardiac CT only (Gr.B; n = 55). The feasibility (i.e. adequate visualization of coronary artery segments) was noninferior with simultaneous cardiac and lung CT compared with the standard cardiac CT (870 of 889 segments [97%] in Gr.A vs 878/890 segments [99%] in Gr.B; mean difference 2.0% [90% confidence interval: −0.3% to 4.1%]). The safety (i.e. effective radiation dose) of the concomitant cardiac and lung CT protocol was noninferior to the standard cardiac CT (1.5 [95% confidence intervals: 1.2–1.7] vs. 1.4 [95% confidence intervals: 1.1–1.6] mSv; mean difference 0.1 mSv [90% confidence interval: −0.2 to 0.3 mSv]). In the two groups, a total of 25 significant (>70%) coronary stenoses were found at cardiac CT (9/55 cases of Gr.A vs 11/55 cases of Gr.B). Pulmonary nodules >2 mm were detected in 7 of the 55 Gr.A subjects. This pilot randomised study shows that concomitant CAD and lung cancer screening by means of a new CT protocol is both feasible and safe, thus allowing a comprehensive evaluation of both cardiac and thoracic regions during one CT scanning only. (ClinicalTrials.gov Identifier: NCT03727958).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Concomitant screening of coronary artery disease and lung cancer with a new ultrafast-low-dose Computed Tomography protocol: A pilot randomised trial

Gaudio

Tanzilli

Mei

et al. 2019

Sci Rep

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“…Sei Komatsu 1, 2) * , Satoru Takahashi 1) , Chikao Yutani 2,3,4) , Tomoki Ohara 1) , Mitsuhiko Takewa 1) , Atsushi Hirayama 2,5) and Kazuhisa Kodama 1,2,5) Aortic angioscopy using non-obstructive general angioscopy (NOGA) is a novel, video-based technique that allows visualization of the inner aorta. Dual infusion method improves the visual field and the use of an Ikari-L guiding catheter allows easy access to the aorta, enabling NOGA of not only the coronary artery but also aorta.…”

Section: Non-obstructive General Angioscopymentioning

confidence: 99%

“…However, their representation of atherosclerosis is partial and indirect 2,3) . CT angiography (CTA) has limited spatial resolution, up to 230 μm of the next-generation CT 5,6) . CTA may provide static grayscale images and even four-dimensional images.…”

Section: Introductionmentioning

confidence: 99%