Diagnostic accuracy of endometrial thickness for the detection of intra-uterine pathologies and appropriateness of performed hysteroscopies among asymptomatic postmenopausal women

Giannella, Luca; Mfuta, Kabala; Setti, Tiziano; Boselli, F.; Bergamini, Ezio; Cerami, Lillo Bruno

doi:10.1016/j.ejogrb.2014.03.025

Cited by 50 publications

(48 citation statements)

References 23 publications

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“…A total of nine studies, published between 2001 and 2016, reporting on 4751 asymptomatic postmenopausal women were included …”

Section: Resultsmentioning

confidence: 99%

“…Table summarizes the patients, interventions, comparatives, and outcomes characteristics of all nine included studies. Four studies were prospective and five were retrospective . All studies used the “double layer” technique for measuring ET.…”

Section: Resultsmentioning

confidence: 99%

“…All studies used the “double layer” technique for measuring ET. Most studies used hysteroscopy as the method for endometrial sampling . Three studies used hysteroscopy, aspiration biopsy or dilatation, and curettage .…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Risk of endometrial cancer and endometrial hyperplasia with atypia in asymptomatic postmenopausal women with endometrial thickness ≥11 mm: A systematic review and meta‐analysis

Alcázar

Bonilla

Marucco³

et al. 2018

J of Clinical Ultrasound

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“…A total of nine studies, published between 2001 and 2016, reporting on 4751 asymptomatic postmenopausal women were included …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Risk of endometrial cancer and endometrial hyperplasia with atypia in asymptomatic postmenopausal women with endometrial thickness ≥11 mm: A systematic review and meta‐analysis

Alcázar

Bonilla

Marucco³

et al. 2018

J of Clinical Ultrasound

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“…Each woman was subjected to an endometrial sampling which we considered our reference standard. Based on our previous study [16], a Vabra endometrial sampling was performed in women without any intrauterine lesion; a targeted biopsy along with random biopsies of each uterine wall was performed in women with suspected premalignant or malignant lesion; intrauterine lesion resection was performed in women with polyps or myomas; all women with an atypical endometrial hyperplasia (AEH), as well as all women with an intrauterine malignancy, underwent a hysterectomy which represented our reference standard as definitive histological finding.…”

Section: Methodsmentioning

confidence: 99%

A Risk-Scoring Model for the Prediction of Endometrial Cancer among Symptomatic Postmenopausal Women with Endometrial Thickness > 4 mm

Giannella

Mfuta

Setti

et al. 2014

BioMed Research International

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Objective. To develop and test a risk-scoring model for the prediction of endometrial cancer among symptomatic postmenopausal women at risk of intrauterine malignancy. Methods. We prospectively studied 624 postmenopausal women with vaginal bleeding and endometrial thickness > 4 mm undergoing diagnostic hysteroscopy. Patient characteristics and endometrial assessment of women with or without endometrial cancer were compared. Then, a risk-scoring model, including the best predictors of endometrial cancer, was tested. Univariate, multivariate, and ROC curve analysis were performed. Finally, a split-sampling internal validation was also performed. Results. The best predictors of endometrial cancer were recurrent vaginal bleeding (odds ratio (OR) = 2.96), the presence of hypertension (OR = 2.01) endometrial thickness > 8 mm (OR = 1.31), and age > 65 years (OR = 1.11). These variables were used to create a risk-scoring model (RHEA risk-model) for the prediction of intrauterine malignancy, with an area under the curve of 0.878 (95% CI 0.842 to 0.908; P < 0.0001). At the best cut-off value (score ≥ 4), sensitivity and specificity were 87.5% and 80.1%, respectively. Conclusion. Among symptomatic postmenopausal women with endometrial thickness > 4 mm, a risk-scoring model including patient characteristics and endometrial thickness showed a moderate diagnostic accuracy in discriminating women with or without endometrial cancer. Based on this model, a decision algorithm was developed for the management of such a population.

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“…The success rate of diagnostic hysteroscopy was 89%, but 97% of these revealed a benign intra-uterine pathology. The diagnostic accuracy of hysteroscopy was optimal for all intra-uterine pathologies, except endometrial hyperplasia [6].…”

Section: Endometrial Thicknessmentioning

confidence: 96%

The Role of Hysteroscopy In Endometrial Cancer

Adonakis

Paschopoulos²,

Georgios³

2015

IJCTD

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Diagnostic accuracy of endometrial thickness for the detection of intra-uterine pathologies and appropriateness of performed hysteroscopies among asymptomatic postmenopausal women

Cited by 50 publications

References 23 publications

Risk of endometrial cancer and endometrial hyperplasia with atypia in asymptomatic postmenopausal women with endometrial thickness ≥11 mm: A systematic review and meta‐analysis

Risk of endometrial cancer and endometrial hyperplasia with atypia in asymptomatic postmenopausal women with endometrial thickness ≥11 mm: A systematic review and meta‐analysis

A Risk-Scoring Model for the Prediction of Endometrial Cancer among Symptomatic Postmenopausal Women with Endometrial Thickness > 4 mm

The Role of Hysteroscopy In Endometrial Cancer

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