Diagnostic accuracy of fine needle aspiration biopsy in preoperative diagnosis of patients with parotid gland masses

Carrillo, José F.; Ramirez, R.; Flores, Lorena; Ramírez-Ortega, Margarita; Arrecillas, Myrna; Ibarra, Margarita; Sotelo, Rita; Ponce-de-León, Samuel; Oñate‐Ocaña, Luis F.

doi:10.1002/jso.21317

Cited by 63 publications

(50 citation statements)

References 30 publications

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“…Furthermore misdiagnosis could result in both hazardous under-treatment, and potentially avoidable overtreatment with permanent facial static and dynamic disfigurement. Fine-needle aspiration cytology (FNAC) guided by ultrasound (US) imaging is widely used to evaluate both neoplastic and inflammatory lesions of the salivary glands, albeit with variable success; sensitivity ranges from 57% to 98%, specificity from 56% to 100%, and accuracy from 78% to 98% [5][6][7][8][9][10][11][12][13][14][15][16] which also depends on the expertise and experience of the pathologist. FNAC is obtained in all salivary gland nodules, and normally performed in reference centers dealing with parotid gland tumors.…”

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of Quasistatic Ultrasound Elastography (USE) compared with Baseline US for parotid gland lesions: preliminary results of elasticity contrast index (ECI) evaluation

et al. 2017

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Aims: To assess the diagnostic value of elasticity contrast index (ECI) elastography, in comparison with conventional ultrasound for the differentiation of benign and malignant parotid lesions. Material and methods: Sixty-three consecutive patients with parotid gland tumors, treated surgically at a single tertiary center were enrolled. Ultrasound evaluation consisted of B-mode, color-Doppler and quasistatic ultrasound elastography (USE), conducted with the ECI technique. For each lesion the echogenicity, margins, vascularization, and capsulation were considered to determine benign or malignant lesions. Histology was considered the gold standard. Results: Using conventional parameters, the observer suggested malignant lesions in 20 cases and benign lesions in 43 cases (accuracy: 61.8%). ECI>3.5 alone was the most accurate parameter (accuracy: 90.5%), with sensitivity of 93.7% and specificity of 89.4%. However, when combined with the other US criteria, no statistically significant diagnostic accuracy improvement was achieved. Conclusions: Our results show that USE with ECI index measurement can help to discriminate preoperatively benign from malignant lesions, with the exception of pleomorphic adenoma which is stiff. We suggest that USE can be used as an additional tool to conventional US evaluation of salivary gland lesions.

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Section: Introductionmentioning

confidence: 99%

Prospective evaluation of Quasistatic Ultrasound Elastography (USE) compared with Baseline US for parotid gland lesions: preliminary results of elasticity contrast index (ECI) evaluation

et al. 2017

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“…It is also widely used in the head and neck regions, such as in the thyroid, lymph nodes, major salivary glands and others neoplasias. 2,[4][5][6][7] In the oral cavity, the FNAB method is rarely used. The most common masses biopsied in this manner are odontogenic tumors, intraosseous lesions, minor salivary gland tumors, sublingual salivary glands and other oral regions.…”

Section: Introductionmentioning

confidence: 99%

Fine needle aspiration biopsy in the oral cavity and head and neck region

et al. 2011

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Abstract:The objective of the current study was to evaluate the sensitivity, specificity and accuracy of fine needle aspiration biopsy (FNAB) of submucous nodules from the oral cavity and head and neck region as an auxiliary diagnostic tool. Fifty patients with nodule lesions in the oral cavity and the head and neck region were selected. All of them were submitted to FNAB and to either incisional or excisional biopsy. The diagnoses from the FNABs were compared with the biopsy diagnosis as the gold standard. All the cases of FNAB were analyzed by a single oral pathologist prior to the biopsy diagnosis. The results showed that the sensitivity of FNAB was 75%, its specificity was 96% and its accuracy was 58.8%. The false positive and false negative rates were 6.7% and 13.3%, respectively. The positive predictive value was 86% and the negative predictive value was 93%. The inconclusive rate was 16/50. FNAB displayed a high success rate for identifying both malignant and benign lesions, but a low accuracy for making a final diagnosis.

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“…Fine-needle aspiration has a higher sensitivity/specificity for benign masses than for malignancy. 4 Carrillo et al 5 also noted that FNA has the potential to change the clinical approach for up to one-third of patients. Salivary lesions remain, however, one of the most challenging entities in cytopathology, mainly because of the diversity of histologic subtypes and the often overlapping morphologic features of the lesions.…”

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confidence: 99%

Fine-Needle Aspiration Biopsy of Salivary Gland Lesions

Wang

Fundakowski²,

Khurana³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Fine-needle aspiration (FNA) is a well-established diagnostic approach for salivary gland lesions; however, lack of a standard system of terminology for classification of salivary gland neoplasms collected by FNA and the relatively high frequency of uncertainty of diagnosis are likely partly responsible for current confusion in the interpretation of these FNA samples.Objective.-To propose a novel classification system for reporting salivary gland FNA samples and summarize recent progress in application of molecular and immunohistochemical markers in selected salivary gland neoplasms.Data Sources.-Literature review and authors' personal practice experience.Conclusions.-The new classification system provides a more succinct, standardized interpretation of results and will ultimately assist in communication between clinicians, clinical decision making, and preoperative patient counseling. Impressive advances have been made in recent years in the understanding of molecular pathogenesis of salivary gland tumors. With the newly acquired diagnostic tools, significant improvement in diagnostic accuracy of salivary gland FNA can certainly be expected.(Arch Pathol Lab Med. 2015;139:1491-1497; doi: 10.5858/arpa.2015-0222-RA) M asses or cystic lesions of salivary glands have a wide range of differential diagnoses, from inflammatory response to neoplasm and to less common causes of infection.1 The World Health Organization has described 45 morphologic types of primary salivary gland tumors. Fine-needle aspiration (FNA) is a well-established diagnostic approach for salivary gland lesions. Zbaren et al 3 have noted accuracy, sensitivity, and specificity rates for salivary gland FNA of 79% (87 of 110), 74% (50 of 68), and 88% (37 of 42), respectively. Fine-needle aspiration has a higher sensitivity/specificity for benign masses than for malignancy. 4 Carrillo et al 5 also noted that FNA has the potential to change the clinical approach for up to one-third of patients. Salivary lesions remain, however, one of the most challenging entities in cytopathology, mainly because of the diversity of histologic subtypes and the often overlapping morphologic features of the lesions.

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Diagnostic accuracy of fine needle aspiration biopsy in preoperative diagnosis of patients with parotid gland masses

Abstract: Diagnostic accuracy for FNAB was very high. No clinical or radiological factors improved the positive LR of FNAB alone. Liberal use of FNAB of PGM is recommended.

Cited by 63 publications

References 30 publications

Prospective evaluation of Quasistatic Ultrasound Elastography (USE) compared with Baseline US for parotid gland lesions: preliminary results of elasticity contrast index (ECI) evaluation

Prospective evaluation of Quasistatic Ultrasound Elastography (USE) compared with Baseline US for parotid gland lesions: preliminary results of elasticity contrast index (ECI) evaluation

Fine needle aspiration biopsy in the oral cavity and head and neck region

Fine-Needle Aspiration Biopsy of Salivary Gland Lesions

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