Diagnostic accuracy of interferon (IFN)-γ inducible protein 10 (IP-10) as a biomarker for the discrimination of active and latent tuberculosis

Mamishi, Setareh; Mahmoudi, Shima; Banar, Maryam; Sadeghi, Reihaneh Hosseinpour; Marjani, Majid; Pourakbari, Babak

doi:10.1007/s11033-019-05067-0

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…Moreover, IP-10 secretion level after stimulation of recombinant mycobacterial antigen proline-glutamate 35 (PE35) and proline-proline-glutamate 68 (PPE68) is significantly higher in TB patients, including pulmonary TB and latent TB, when it was compared with HCs (45). However, there is no significant difference in IP-10 production induced by PE35 and PPE68 between pulmonary TB and latent TB (45). A recent systemic review and meta-analysis showed that IP-10 test is useful alternative immunological modality to detect children TB (46).…”

Section: Roles Of Chemokines As Biomarkers During Tb and Extrapulmonary Tb Cxcl10/ip-10 As Biomarkers During Tb Infectionmentioning

confidence: 99%

The Roles of Chemokines in Immune Response to Mycobacterial Infection

Paik

Yang

Suh

et al. 2020

jbv

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Tuberculosis (TB), a global and deadly infectious disease caused by Mycobacterium tuberculosis (Mtb), is manifested with host immune reaction. The balanced regulation between protective immune and pathologic inflammatory responses is critical to control progression to TB. Chemokines are a large family of cytokines that play an essential role for chemotaxis of immune and inflammatory cells to the sites of infection. Numerous chemokines including CXCL10 were reported as potential biomarkers of various stages of TB infection. In addition, several chemokines and their receptors play as key players to coordinate host immune defense as innate effectors and mediators of adaptive immune responses. Accumulating evidence suggests that some chemokines, if uncontrolled, are associated with host pathological inflammation during infection. In this review, we will discuss recent advances in understanding which chemokines have potentials as diagnostic markers. In addition, we focus the roles and mechanisms by which chemokines and their receptors are involved in both host immune protection and pathology during TB infection. The controlled activation of chemokine system will determine the coordinated biological outcomes of innate immune responses during pathogenic infection.

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Section: Roles Of Chemokines As Biomarkers During Tb and Extrapulmonary Tb Cxcl10/ip-10 As Biomarkers During Tb Infectionmentioning

confidence: 99%

The Roles of Chemokines in Immune Response to Mycobacterial Infection

Paik

Yang

Suh

et al. 2020

jbv

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“…In most cases, the threshold is determined by the receiver operating characteristic curve with maximised sensitivity and specificity. 32 33 However, in areas with a low burden of tuberculosis, the threshold may be set at a lower level in order to better distinguish the active and latent tuberculosis. 34 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of cytokines as a biomarker to distinguish active tuberculosis from latent tuberculosis infection: a diagnostic meta-analysis

Qiu

et al. 2020

BMJ Open

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ObjectivesWith a marginally effective vaccine and no significant breakthroughs in new treatments, a sensitive and specific method to distinguish active tuberculosis from latent tuberculosis infection (LTBI) would allow for early diagnosis and limit the spread of the pathogen. The analysis of multiple cytokine profiles provides the possibility to differentiate the two diseases.DesignSystematic review and meta-analysis.Data sourcesPubMed, Cochrane Library, Clinical Key and EMBASE databases were searched on 31 December 2019.Eligibility criteriaWe included case–control studies, cohort studies and randomised controlled trials considering IFN-γ, TNF-α, IP-10, IL-2, IL-10, IL-12 and VEGF as biomarkers to distinguish active tuberculosis and LTBI.Data extraction and synthesisTwo students independently extracted data and assessed the risk of bias. Diagnostic OR, sensitivity, specificity, positive and negative likelihood ratios and area under the curve (AUC) together with 95% CI were used to estimate the diagnostic value.ResultsOf 1315 records identified, 14 studies were considered eligible. IL-2 had the highest sensitivity (0.84, 95% CI: 0.72 to 0.92), while VEGF had the highest specificity (0.87, 95% CI: 0.73 to 0.94). The highest AUC was observed for VEGF (0.85, 95% CI: 0.81 to 0.88), followed by IFN-γ (0.84, 95% CI: 0.80 to 0.87) and IL-2 (0.84, 95% CI: 0.81 to 0.87).ConclusionCytokines, such as IL-2, IFN-γ and VEGF, can be utilised as promising biomarkers to distinguish active tuberculosis from LTBI.PROSPERO registration numberCRD42020170725.

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“…An increased level of IP-10 has been reported in patients with active TB compared to LTBI. 46,47 In addition, the IP-10 level is less affected by immunosuppressive conditions. In contrast to IFN -γ, IP-10 is not affected in HIV patients with low CD4 count.…”

Section: Ip10mentioning

confidence: 99%

“…A noteworthy feature of IP‐10 is its performance in discriminating active TB from LTBI. An increased level of IP‐10 has been reported in patients with active TB compared to LTBI 46,47 …”

Section: Tb Associated Biomarkers In Ramentioning

confidence: 99%

Tuberculosis comorbidity with rheumatoid arthritis: Gene signatures, associated biomarkers, and screening

et al. 2020

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Rheumatoid arthritis (RA) is known to be related to an elevated risk of infections because of its pathobiology and the use of immunosuppressive therapies. Reactivation of latent tuberculosis (TB) infection is a serious issue in patients with RA, especially after receiving anti-TNFs therapy. TNF blocking reinforces the TB granuloma formation and maintenance and the growth of Mycobacterium tuberculosis (Mtb). After intercurrent of TB infection, the standard recommendation is that the treatment with TNF inhibitors to be withheld despite its impressive effect on suppression of inflammation until the infection has resolved. Knowing pathways and mechanisms that are common between two diseases might help to find the mechanistic basis of this comorbidity, as well as provide us a new approach to apply them as therapeutic targets or diagnostic biomarkers. Also, screening for latent TB before initiation of an anti-TNF therapy can minimize complications. This review summarizes the shared gene signature between TB and RA and discusses the biomarkers for early detection of this infection, and screening procedures as well.

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Diagnostic accuracy of interferon (IFN)-γ inducible protein 10 (IP-10) as a biomarker for the discrimination of active and latent tuberculosis

Cited by 16 publications

References 27 publications

The Roles of Chemokines in Immune Response to Mycobacterial Infection

The Roles of Chemokines in Immune Response to Mycobacterial Infection

Evaluation of cytokines as a biomarker to distinguish active tuberculosis from latent tuberculosis infection: a diagnostic meta-analysis

Tuberculosis comorbidity with rheumatoid arthritis: Gene signatures, associated biomarkers, and screening

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