Diagnostic accuracy of lipopolysaccharide-binding protein for predicting bacteremia/clinical sepsis in children with febrile neutropenia: comparison with interleukin-6, procalcitonin, and C-reactive protein

Kitanovski, Lidija; Jazbec, Janez; Hojker, Sergej; Derganc, Metka

doi:10.1007/s00520-013-1978-1

Cited by 40 publications

(47 citation statements)

References 43 publications

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“…Procalcitonin is another parameter of infection that showed a significant increase (p<0.001) in FS patients compared with that of the control group (Table 1), that has been discussed previously (24).PCT increases in bacterial infection and is an accurate predictor of a serious bacterial infection (12,25).…”

Section: Discussion Comparison Between Fs Patients and Control Groupssupporting

confidence: 54%

See 1 more Smart Citation

Efficiency of Fetuin-A and Procalcitonin in the Diagnosis of Infection in Patients with Febrile Seizure

Al‐Hakeim¹,

Al-Ankoshy²,

Alsharifi³

2016

Acta Facultatis Medicae Naissensis

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Fetuin-A level decreased and PCT level increased in FS patients in comparison to those in the control group. These changes are significantly increased (p<0.05) in the positive CRP group compared with that of the negative CRP group. Kernel density estimation showed that procalcitonin is a better indicator of the infection in FS children than fetuin-A . Procalcitonin is more sensitive and specific than fetuin-A and when used together they produce 100% sensitivity and specificity for the diagnosis of bacterial infection in FS patients.Fetuin-A is low in FS patients and can be used with procalcitonin in the diagnosis of bacterial infection in FS.

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Section: Discussion Comparison Between Fs Patients and Control Groupssupporting

confidence: 54%

“…Presently, some physician use PCT to differentiate FS patients with bacterial and nonbacterial infectious causes (12).…”

Section: Introductionmentioning

confidence: 99%

Efficiency of Fetuin-A and Procalcitonin in the Diagnosis of Infection in Patients with Febrile Seizure

Al‐Hakeim¹,

Al-Ankoshy²,

Alsharifi³

2016

Acta Facultatis Medicae Naissensis

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“…CRP is a useful marker of the severity of an infection, and resistin may function similarly as a prognostic factor. Previous studies have reported that resistin may indicate the severity of the disease in patients with neonatal sepsis, in a similar manner to IL-6 and CRP (7,14,23,24). Furthermore, recent studies have demonstrated that resistin may serve a function in inflammation and autoimmunity (5,25).…”

Section: Discussionmentioning

confidence: 89%

“…However, using the CRP response as a biomarker for cellulitis has a number of disadvantages, including a delayed release and low specificity. Thus, numerous biomarkers, including resistin, have been studied in association with infectious diseases (8,(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Clinical potential of resistin as a novel prognostic biomarker for cellulitis

Ertürk

Cüre

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Cellulitis is an acute, subacute or chronic inflammation of the dermis and subdermal tissues, which is typically caused by bacteria, although other causes are possible. The present study aimed to evaluate the association between resistin levels and the recovery time of patients with cellulitis. In addition, the effect of resistin and insulin resistance on the prognosis of cellulitis was investigated. In total, 52 patients with cellulitis (male, 21; female, 31) and an age-matched group of 42 healthy individuals (male, 18; female, 24) were included in the study. The levels of serum resistin, fasting plasma glucose (FPG), homeostasis model assessment-insulin resistance (HOMA-IR), C-reactive protein (CRP) and other biochemical parameters were compared between the groups. The mean resistin levels in the cellulitis and control groups were 9.4±5.3 and 5.8±3.1 ng/ml, respectively. The levels of resistin, FPG, HOMA-IR and CRP were significantly higher in the cellulitis group compared with the control group (P<0.001). Furthermore, the mean recovery time of the patients with cellulitis was 21.2±5.6 days. Thus, increased levels of resistin (P=0.002) and HOMA-IR (P=0.005) could be used as predictive factors for the recovery time. The enhanced levels of resistin and HOMA-IR were shown to correlate with the high CRP levels in the cellulitis group. Therefore, the results indicated that increased levels of resistin may function as a prognostic marker for cellulitis.

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“…IL-6 has been shown to be a sensitive biomarker for predicting bacteremia/clinical sepsis in children with febrile neutropenia [45,46]. In severe sepsis, the best diagnostic accuracies were found for I-6 and procalcitonin and these were significantly higher than those for Lipopolysaccharide-Binding Protein (LBP) on admission [46].…”

Section: Interleukin 6 (Il-6)mentioning

confidence: 99%

Sepsis in Children

Mendez¹

2015

ETS

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Diagnostic accuracy of lipopolysaccharide-binding protein for predicting bacteremia/clinical sepsis in children with febrile neutropenia: comparison with interleukin-6, procalcitonin, and C-reactive protein

Abstract: On admission and 24 h later, the LBP concentration is less accurate for predicting bacteremia/clinical sepsis compared to IL-6, PCT, and CRP.

Cited by 40 publications

References 43 publications

Efficiency of Fetuin-A and Procalcitonin in the Diagnosis of Infection in Patients with Febrile Seizure

Efficiency of Fetuin-A and Procalcitonin in the Diagnosis of Infection in Patients with Febrile Seizure

Clinical potential of resistin as a novel prognostic biomarker for cellulitis

Sepsis in Children

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