2020
DOI: 10.1515/med-2020-0038
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Diagnostic accuracy of MALDI-TOF mass spectrometry for the direct identification of clinical pathogens from urine

Abstract: AbstractMatrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) has become one of the most popular methods for the rapid and cost-effective detection of clinical pathogenic microorganisms. This study aimed to evaluate and compare the diagnostic performance of MALDI-TOF MS with that of conventional approaches for the direct identification of pathogens from urine samples. A systematic review was conducted based on a literature search of relevan… Show more

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Cited by 8 publications
(1 citation statement)
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“…Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) in particular is well-documented in identifying A. urinae using non-culture techniques [ 1 ]. Conventional methods of UTI identification require 18-48 hours of culturing, while MALDI-TOF MS reduces processing time to under an hour with excellent specificity and sensitivity, further minimizing inappropriate empirical antimicrobial therapy before identification [ 7 ].…”
Section: Discussionmentioning
confidence: 99%
“…Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) in particular is well-documented in identifying A. urinae using non-culture techniques [ 1 ]. Conventional methods of UTI identification require 18-48 hours of culturing, while MALDI-TOF MS reduces processing time to under an hour with excellent specificity and sensitivity, further minimizing inappropriate empirical antimicrobial therapy before identification [ 7 ].…”
Section: Discussionmentioning
confidence: 99%