Diagnostic Accuracy of MRI for Assessment of T Category and Circumferential Resection Margin Involvement in Patients With Rectal Cancer

Zhang, Ge; Cai, Yu-Zhe; Xu, Gaixia

doi:10.1097/dcr.0000000000000611

Cited by 56 publications

(53 citation statements)

References 71 publications

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“…The accessibility of rectal cancer to evaluation by pelvic MRI with contrast makes possible preoperative assessments of depth of tumor penetration and the presence of local lymph nodal metastases. 11,12 Pelvic MRI has the ability to provide accurate images of soft tissue structures in the mesorectum, including the mesorectal fascia so as to provide information useful in the prediction of the clear circumferential margin (CRM) before radical surgery. [13][14][15][16][17][18] The CRM by MRI is measured at the closest distance of the tumor to the mesorectal fascia.…”

Section: Preoperative Pelvic Imaging In Rectal Cancermentioning

confidence: 99%

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Benson¹,

Venook²,

Al-Hawary³

et al. 2018

J Natl Compr Canc Netw

830

670

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The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Rectal Cancer address diagnosis, staging, surgical management, perioperative treatment, management of recurrent and metastatic disease, disease surveillance, and survivorship in patients with rectal cancer. This portion of the guidelines focuses on the management of localized disease, which involves careful patient selection for curative-intent treatment options that sequence multimodality therapy usually comprised of chemotherapy, radiation, and surgical resection.

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Section: Preoperative Pelvic Imaging In Rectal Cancermentioning

confidence: 99%

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Benson¹,

Venook²,

Al-Hawary³

et al. 2018

J Natl Compr Canc Netw

830

670

View full text Add to dashboard Cite

show abstract

“…They report a lower diagnostic accuracy of staging T1 and T2 tumors compared with T3 and T4 tumors. 31 Given that the multi-echo acquisition was run as part of a split-dynamic MRI framework, simulations were performed to investigate whether the splitting of dynamic time- FIGURE 3: High temporal resolution DR 1 -(a) and DR Ã 2 -time curves (b) from four rectal cancer patients, and corresponding T 2 -weighted images merged with parametrical maps representing R Ã 2 -peak enh (c-f). The DR 1 -and DR Ã 2 -time curves were extracted using a region of interest (red outline), drawn by an experienced radiologist, delineating the tumor at a central slice.…”

Section: Discussionmentioning

confidence: 99%

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis

Grøvik

Redalen

Storås

et al. 2016

J. Magn. Reson. Imaging

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Purpose: To implement a dynamic contrast-based multi-echo MRI sequence in assessment of rectal cancer and evaluate associations between histopathologic data and the acquired dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) -MRI parameters. Materials and Methods: This pilot study reports results from 17 patients with resectable rectal cancer. Dynamic contrast-based multi-echo MRI (1.5T) was acquired using a three-dimensional multi-shot EPI sequence, yielding both DCE-and DSC-data following a single injection of contrast agent. The Institutional Review Board approved the study and all patients provided written informed consent. Quantitative analysis was performed by pharmacokinetic modeling on DCE data and tracer kinetic modeling on DSC data. Mann-Whitney U-test and receiver operating characteristics curve statistics was used to evaluate associations between histopathologic data and the acquired DCE-and DSC-MRI parameters. Results: For patients with histologically confirmed nodal metastasis, the primary tumor demonstrated a significantly lower K trans and peak change in R Ã 2 , R Ã 2 -peak enh , than patients without nodal metastasis, showing a P-value of 0.010 and 0.005 for reader 1, and 0.043 and 0.019 for reader 2, respectively. Conclusion: This study shows the feasibility of acquiring DCE-and DSC-MRI in rectal cancer by dynamic multi-echo MRI. A significant association was found between both K trans and R Ã 2 -peak enh in the primary tumor and histological nodal status of the surgical specimen, which may improve stratification of patients to intensified multimodal treatment.

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“…Colorectal cancer is nowadays the third most common cancer in men and the second in women worldwide, accounting for 9% of new cancer cases and 9% of cancer-specific deaths. [ 1 , 2 ] Approximately 1 in 3 of these tumors are rectal cancers. [ 3 ] In the USA, rectal cancer is a major cause of mortality, and there were an estimated 39,220 new cases in 2016.…”

Section: Introductionmentioning

confidence: 99%

“…[ 15 – 17 ] Nowadays, treatment of rectal cancer with different locations and stages mainly includes transanal endoscopic microsurgery, anterior resection with total mesorectal excision, abdominoperineal resection, and neoadjuvant chemotherapy and radiotherapy. [ 2 , 18 , 19 ] Accurate preoperative assessment of lymph node involvement is essential for selecting patients to receive optimal treatment. [ 2 , 20 ]…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of endoscopic ultrasound, computed tomography, magnetic resonance imaging, and endorectal ultrasonography for detecting lymph node involvement in patients with rectal cancer

et al. 2018

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Background:Rectal cancer is one of the most common tumors and is the leading cause of cancer-related deaths in developed countries. Lymph node involvement remains the strongest prognostic factor associated with a worse prognosis in patients with rectal cancer. Several systematic reviews have investigated the accuracy of endoscopic ultrasound, computed tomography, magnetic resonance imaging, and endorectal ultrasonography for lymph node involvement of rectal cancer and compared the diagnostic accuracy of different imaging techniques, but there are considerable differences in conclusions. This study aims to assess the methodological quality and reporting quality of systematic reviews and to determine which diagnostic imaging techniques is the optimal modality for the diagnosis of lymph node involvement in patients with rectal cancer.Methods:We will search PubMed, EMBASE, Cochrane Library, and Chinese Biomedicine Literature to identify relevant studies from inception to June 2018. We will include systematic reviews that evaluated the accuracy of diagnostic imaging techniques for lymph node involvement. The methodological quality will be assessed using AMASAR checklist, and the reporting quality will be assessed using PRISMA-DTA checklist. The pairwise meta-analysis and indirect comparisons will be performed using STATA V.12.0.Results:The results of this overview will be submitted to a peer-reviewed journal for publication.Conclusion:This overview will provide comprehensive evidence of different diagnostic imaging techniques for detecting lymph node involvement in patients with rectal cancer.Ethics and dissemination:Ethics approval and patient consent are not required as this study is an overview based on published systematic reviews.PROSPERO registration number:CRD42018104906.

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Diagnostic Accuracy of MRI for Assessment of T Category and Circumferential Resection Margin Involvement in Patients With Rectal Cancer

Abstract: MRI showed relatively high diagnostic accuracy for preoperative T staging and circumferential resection margin assessment and should be reliable for clinical decision making.

Cited by 56 publications

References 71 publications

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis

Diagnostic accuracy of endoscopic ultrasound, computed tomography, magnetic resonance imaging, and endorectal ultrasonography for detecting lymph node involvement in patients with rectal cancer

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Diagnostic Accuracy of MRI for Assessment of T Category and Circumferential Resection Margin Involvement in Patients With Rectal Cancer

Abstract: MRI showed relatively high diagnostic accuracy for preoperative T staging and circumferential resection margin assessment and should be reliable for clinical decision making.

Cited by 56 publications

References 71 publications

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor Ktrans and ΔR2* peak are significantly associated with lymph node metastasis

Diagnostic accuracy of endoscopic ultrasound, computed tomography, magnetic resonance imaging, and endorectal ultrasonography for detecting lymph node involvement in patients with rectal cancer

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Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis