Diagnostic accuracy of probe-based confocal laser endomicroscopy in Lugol-unstained esophageal superficial lesions of patients with head and neck cancer

Safatle‐Ribeiro, Adriana Vaz; Baba, Elisa Ryoka; Faraj, Sheila F.; Lima, Marcelo Simas de; Martins, Bruno Costa; Geiger, Sebastian; Pennacchi, Caterina; Gusman, Carla; Kawaguti, Fábio S.; Uemura, Ricardo S.; Melo, Evandro Sobroza de; Ribeiro, Ulysses; Maluf‐Filho, Fauze

doi:10.1016/j.gie.2016.09.031

Cited by 13 publications

(17 citation statements)

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“…Narrow band imaging (NBI; Olympus Corp., Tokyo, Japan) is considered an attractive, non‐invasive option to yield high accuracy, but its specificity was limited to roughly 50% in a randomized controlled trial . To overcome these drawbacks, more advanced endoscopic imaging techniques have been developed, including confocal laser endomicroscopy (CLE; Mauna Kea Corp., Paris, France) and endocytoscopy (Olympus Corp.) . However, interpreting these microscopic images usually requires expertise and intensive training, which hinders generalization of the technologies to clinical practice.…”

Section: Esophagusmentioning

confidence: 99%

“…31 To overcome these drawbacks, more advanced endoscopic imaging techniques have been developed, including confocal laser endomicroscopy (CLE; Mauna Kea Corp., Paris, France) and endocytoscopy (Olympus Corp.). 32,33 However, interpreting these microscopic images usually requires expertise and intensive training, which hinders generalization of the technologies to clinical practice. Therefore, several research groups developed CAD systems that allow automated image interpretation.…”

Section: Identification Of Sccmentioning

confidence: 99%

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Artificial intelligence and upper gastrointestinal endoscopy: Current status and future perspective

Mori

Kudo

Mohmed

et al. 2019

Digestive Endoscopy

112

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With recent breakthroughs in artificial intelligence, computer‐aided diagnosis (CAD) for upper gastrointestinal endoscopy is gaining increasing attention. Main research focuses in this field include automated identification of dysplasia in Barrett's esophagus and detection of early gastric cancers. By helping endoscopists avoid missing and mischaracterizing neoplastic change in both the esophagus and the stomach, these technologies potentially contribute to solving current limitations of gastroscopy. Currently, optical diagnosis of early‐stage dysplasia related to Barrett's esophagus can be precisely achieved only by endoscopists proficient in advanced endoscopic imaging, and the false‐negative rate for detecting gastric cancer is approximately 10%. Ideally, these novel technologies should work during real‐time gastroscopy to provide on‐site decision support for endoscopists regardless of their skill; however, previous studies of these topics remain ex vivo and experimental in design. Therefore, the feasibility, effectiveness, and safety of CAD for upper gastrointestinal endoscopy in clinical practice remain unknown, although a considerable number of pilot studies have been conducted by both engineers and medical doctors with excellent results. This review summarizes current publications relating to CAD for upper gastrointestinal endoscopy from the perspective of endoscopists and aims to indicate what is required for future research and implementation in clinical practice.

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Section: Esophagusmentioning

confidence: 99%

Section: Identification Of Sccmentioning

confidence: 99%

Artificial intelligence and upper gastrointestinal endoscopy: Current status and future perspective

Mori

Kudo

Mohmed

et al. 2019

Digestive Endoscopy

112

View full text Add to dashboard Cite

show abstract

“…To date, numerous studies have shown the applications of pCLE in vivo diagnosis of esophageal squamous cell carcinoma, biliary tract malignancies, as well as its advantages such as eliminating unnecessary biopsies, detecting tumor margins following resection, and allowing for immediate decision making . Furthermore, pCLE also has been used in the diagnostic differentiation between nonneoplastic, precancerous, and cancerous lesions of the head and neck …”

Section: Introductionmentioning

confidence: 99%

“…14 Furthermore, pCLE also has been used in the diagnostic differentiation between nonneoplastic, precancerous, and cancerous lesions of the head and neck. [15][16][17][18] The aim of our study was to depict the applicability of pCLE examination for diagnosing NPC in comparison to the gold standard of histopathological examination based on the morphology and architecture of the pCLE images.…”

Section: Introductionmentioning

confidence: 99%

Probe‐based confocal laser endomicroscopy for diagnosis of nasopharyngeal carcinoma in vivo

Zhou

et al. 2018

The Laryngoscope

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“…pCLE evaluates the microarchitecture of the mucosal epithelium allowing differentiation between normal and neoplastic mucosa. This technique has been used with high sensitivity and specificity in different scenarios involving the gastrointestinal tract, including esophageal squamous cell carcinoma, Barrett’s esophagus, pancreatic cysts, and colorectal lesions ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Probe-based confocal endomicroscopy is accurate for differentiating gastric lesions in patients in a Western center

Safatle‐Ribeiro

Baba

Scomparin

et al. 2018

Chinese Journal of Cancer Research

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ObjectiveProbe-based confocal laser endomicroscopy (pCLE) technique may improve the diagnosis of gastric mucosal lesions allowing acquisition of high-resolution in vivo images at the cellular and microvascular levels. This study aims to evaluate the accuracy of pCLE for the differential diagnosis of non-neoplastic and neoplastic gastric lesions. MethodsTwenty gastric mucosal lesions from 10 patients were evaluated during endoscopic procedure and were examined by pCLE. Diagnostic pCLE was followed by biopsies or endoscopic resection of suspected lesions. A senior pathologist evaluated the specimens and was blinded to the pCLE results.ResultsPatients’ mean age was 68.3 (range, 42−83) years and six were men. Thirteen suspicious flat or elevated lesions (classified as 0−Is, 0−IIa or 0−IIa + IIc) and seven pre-malignant lesions (atrophy and intestinal metaplasia) were evaluated. One patient was studied during his long-term follow-up after partial gastrectomy and presented severe atrophy, intestinal metaplasia, and xanthomas at the stump mucosa. The location of gastric lesions was in the body (n=10 lesions), the antrum (n=9) and the incisura angularis (n=1). All neoplastic lesions and all but one benign lesion were properly diagnosed by pCLE. pCLE incorrectly diagnosed one small antrum lesion as adenoma, however the final diagnosis was intestinal metaplasia. The final histological diagnosis was neoplastic in 9 and benign lesions in 11. In this small case series, pCLE accuracy was 95% (19/20 lesions).ConclusionspCLE is accurate for real time histology of gastric lesions. pCLE may change the management of patients with gastric mucosal lesions, guiding biopsies and endoscopic resection, and avoiding further diagnostic workup or unnecessary therapy.

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Diagnostic accuracy of probe-based confocal laser endomicroscopy in Lugol-unstained esophageal superficial lesions of patients with head and neck cancer

Cited by 13 publications

References 40 publications

Artificial intelligence and upper gastrointestinal endoscopy: Current status and future perspective

Artificial intelligence and upper gastrointestinal endoscopy: Current status and future perspective

Probe‐based confocal laser endomicroscopy for diagnosis of nasopharyngeal carcinoma in vivo

Probe-based confocal endomicroscopy is accurate for differentiating gastric lesions in patients in a Western center

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