Diagnostic Accuracy of Spectralis SD OCT Automated Macular Layers Segmentation to Discriminate Normal from Early Glaucomatous Eyes

Pazos, Marta; Dyrda, Agnieszka; Biarnés, Marc; Gómez, Alicia; Martín, Carlos; Mora, C.; Fatti, Gianluca; Antón, Alfonso

doi:10.1016/j.ophtha.2017.03.044

Cited by 92 publications

(84 citation statements)

References 35 publications

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“…Retinal thickness is related to a variety of other conditions. For example, reduced thickness of the retinal ganglion cell complex (GCC; a composite retinal layer comprising the retinal layers containing the ganglion cell dendritic synapses with bipolar and amacrine cells, the ganglion cell bodies, and the ganglion cell axons viz., the IPL, GCL, and NFL respectively) has also been associated with a variety of ocular diseases in their early stages, such as glaucoma [56], retinal vessel loss in open-angle glaucoma [57], and chiasmal compression [58]. Similar changes have also been reported in early age-related macular degeneration [59].…”

Section: Discussionmentioning

confidence: 64%

Association of reduced inner retinal thicknesses with chronic kidney disease

Paterson¹,

Ravindran²,

Griffiths³

et al. 2020

BMC Nephrol

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Background: Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and diabetes. We evaluated associations between retinal thickness, retinal microvascular and choroidal measures, and renal function in a population with a high burden of comorbidity. Methods: Participants were recruited from nuclear cardiology or renal medicine clinics. Retinal and choroidal thickness were measured from spectral-domain optical coherence tomograms. Retinal microvascular parameters were assessed from digital fundus photographs using a semi-automated software package. Main Outcome Measure: Chronic kidney disease (CKD) categorised as: CKD stages 1-2, eGFR ≥60 ml/min/1.73m 2 ; CKD stage 3, eGFR 30-59 ml/min/1.73m 2 , and CKD stages 4-5, eGFR ≤29 ml/min/1.73m 2. Results: Participants (n = 241) had a mean age of 65 years and a mean eGFR of 66.9 ml/min/1.73m 2. Thirty-nine % of the cohort had diabetes and 27% were using diuretics. Thinning of the inner retina and changes to its microvascular blood supply were associated with lower eGFR and CKD stages 4 and 5, while no associations were found between the outer retinal layers or their choroidal blood supply and CKD of any stage. These associations remained following adjustment for age, mean arterial blood pressure, diabetes status, low-density lipoprotein, body mass index, and sex. Conclusions: Inner retinal thinning and retinal microvascular variation is associated with advanced CKD (stages 4 & 5) independent of important confounding factors, but not with earlier stage CKD (stage 3) and, therefore, its utility as a biomarker for early CKD is not supported in this study.

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Section: Discussionmentioning

confidence: 64%

Association of reduced inner retinal thicknesses with chronic kidney disease

Paterson¹,

Ravindran²,

Griffiths³

et al. 2020

BMC Nephrol

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“…The recent introduction of Spectralis SD-OCT software designed for the analysis of segmented inner macular layers has rekindled interest in the management of glaucoma in adult patients. Recent studies have shown a good diagnostic capacity of inner macular layer segmentation analysis to differentiate between normal eyes and glaucomatous eyes, comparable to that of cpRNFL thickness, in adults [8].…”

Section: Discussionmentioning

confidence: 94%

“…observed in adults that AUCs for overall mRNFL and GCL thicknesses (0.915 and 0.914) tended to be greater than that for cpRNFL global thickness (0.878), and that the AUC for overall IPL thickness was lower. More recently, a similar study using the same new segmentation Software [8] found that the three best parameters were the temporal-inferior sector of pRNFL (AUC, 0.956), the outer inferior sector of mRNFL (AUC, 0.906), the outer-inferior sector of macular inner retinal layer (AUC, 0.876), the the inner-temporal of mGCL (AUC, 0.858) and the inner-temporal of IPL (AUC, 0.854). This study showed that pRNFL still performed better than the other retinal macular layers assessed separately.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic capacity of SD-OCT segmented ganglion cell complex versus retinal nerve fiber layer analysis for congenital glaucoma

Morales-Fernández

Jiménez-Santos

Martinez-de-la-Casa

et al. 2018

Eye

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“…18 Conversely, some authors did not find any difference between the yield of RNFL and GCC capability to differentiate normal and glaucomatous eyes. 19,20 Nevertheless, VMIAs are a confounding factor for the conclusions that may be drawn from GCC. 21 Therefore, we prompted this study to evaluate the prevalence and potential associations of VMIAs with glaucoma in an elderly population.…”

mentioning

confidence: 99%

Vitreomacular Interface Abnormalities and Glaucoma in an Elderly Population (The MONTRACHET Study)

Blanc

Seydou

Ghezala

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate the prevalence of vitreomacular interface abnormalities (VMIAs) in a French elderly glaucomatous population. METHODS. Using a population-based study, the MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) study conducted in Dijon from 2009 to 2013 in individuals older than 75 years, the prevalence of VMIAs was estimated on glaucoma patients. RESULTS. A total of 1130 participants (2225 eyes) were included in the study. The mean age of participants was 82.3 6 3.8 years, and 62.74% were women. Regarding the frequency of all VMIAs, there was no statistical difference between glaucoma patients and nonglaucoma participants (51.85% vs. 53.92%, respectively, P ¼ 0.372). In univariate analysis, vitreomacular adherences were more frequent in nonglaucoma participants (18.39% vs. 10.78%, P ¼ 0.036). Epiretinal membranes were more frequent in the glaucomatous population (47.06% vs. 38.13%, P ¼ 0.018). The prevalence of macular cysts was comparable in the two groups (7.84% vs. 5.64%, P ¼ 0.262). Macular cysts were more frequent in eyes treated with preservative-free, IOP-lowering eye drops when compared with the eyes of nonglaucomatous participants treated with IOP-lowering eye drops containing a preservative (26.67% vs. 3.37% and 5.76%, respectively, P < 0.001). In multivariate analysis, these results were no longer significant. CONCLUSIONS. The prevalence of VMIAs was high in this elderly population and similar in both glaucomatous and nonglaucomatous participants. The information provided by macular optical coherence tomography scans should be considered with caution when used for glaucoma management in elderly patients.

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Diagnostic Accuracy of Spectralis SD OCT Automated Macular Layers Segmentation to Discriminate Normal from Early Glaucomatous Eyes

Abstract: Macular RNFL, mGCL-IPL, and mGCC measurements showed a high diagnostic capability to discriminate between healthy and EG participants. However, macular intraretinal measurements still have not overcome standard pRNFL parameters.

Cited by 92 publications

References 35 publications

Association of reduced inner retinal thicknesses with chronic kidney disease

Association of reduced inner retinal thicknesses with chronic kidney disease

Diagnostic capacity of SD-OCT segmented ganglion cell complex versus retinal nerve fiber layer analysis for congenital glaucoma

Vitreomacular Interface Abnormalities and Glaucoma in an Elderly Population (The MONTRACHET Study)

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