Diagnostic and analytical performance of a screening panel for allergy

Herzum, Ileana; Blümer, Nicole; Kersten, Werner; Renz, Harald

doi:10.1515/cclm.2005.165

Cited by 36 publications

(35 citation statements)

References 13 publications

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“…However, Herzum et al [10] found that the Allergy Screen panel yields reliable results in the detection of allergic sensitization to common allergens.…”

Section: Discussionmentioning

confidence: 99%

Disagreement between Skin Prick Tests and Specific IgE in Early Childhood

Chauveau

Dalphin

Kaulek

et al. 2016

Int Arch Allergy Immunol

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Background: Accurate diagnosis of allergic sensitization is essential in clinical practice and allergy research, and the choice of assessment method may have an important impact. The PASTURE study (Protection against Allergy: Study of Rural Environment) examines the influence of exposure to a dairy farm environment on the occurrence of allergy in a cohort of rural European children from birth to 10 years. The aim of our study was to analyze agreement between skin prick tests (SPTs), to aeroallergens and food allergens, and specific IgE and to evaluate the association of SPT with atopic dermatitis in the 204 French children of the PASTURE study. Methods: SPT, atopic dermatitis assessment, and specific IgE measurements were performed at 1, 4.5, and 6 years. Results: A total of 137 children attended all three visits. The agreement between SPTs and specific IgE was poor except for perennial aeroallergens at 6 years and for an IgE cutoff greater than 0.7 IU/ml (κ = 0.69, 0.5202 - 0.8621). The prevalence of positive SPTs increased with age. Positive SPTs were transient at 1 year, whereas they were persistent between 4.5 and 6 years. Positive SPTs at 1 year were predictive of the occurrence of atopic dermatitis during follow-up. Conclusion: SPTs did not have good agreement with serum-specific IgE in early childhood. Both tests (SPT and specific IgE) should be used. Skin allergenic reactivity increased with age and was transient at 1 year but associated with the occurrence of atopic dermatitis.

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“…However, Herzum et al [10] found that the Allergy Screen panel yields reliable results in the detection of allergic sensitization to common allergens.…”

Section: Discussionmentioning

confidence: 99%

Disagreement between Skin Prick Tests and Specific IgE in Early Childhood

Chauveau

Dalphin

Kaulek

et al. 2016

Int Arch Allergy Immunol

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“…Venous blood samples collected from children at the ages of 1 and 6 years, and from mothers and fathers, were analyzed for allergen-specific immunoglobulin E (IgE) to 19 common allergens (Mediwiss Analytic, Moers, Germany) 14 ; 13 inhalant and 6 food allergens were included. 10 The cutoff level to define atopic sensitization to inhalant allergens was 0.70 kU/L at the age of 6 years, and this factor was analyzed in 310 children with data on home inspection in infancy.…”

Section: Immunoglobulin E Determinationsmentioning

confidence: 99%

Moisture Damage and Asthma: A Birth Cohort Study

et al. 2015

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BACKGROUND: Excess moisture and visible mold are associated with increased risk of asthma. Only a few studies have performed detailed home visits to characterize the extent and location of moisture damage and mold growth.METHODS: Structured home inspections were performed in a birth cohort study when the children were 5 months old (on average). Children (N = 398) were followed up to the age of 6 years. Specific immunoglobulin E concentrations were determined at 6 years.RESULTS: Moisture damage and mold at an early age in the child's main living areas (but not in bathrooms or other interior spaces) were associated with the risk of developing physiciandiagnosed asthma ever, persistent asthma, and respiratory symptoms during the first 6 years. Associations with asthma ever were strongest for moisture damage with visible mold in the child's bedroom (adjusted odds ratio: 4.82 [95% confidence interval: 1.29-18.02]) and in the living room (adjusted odds ratio: 7.51 [95% confidence interval: 1.49-37.83]). Associations with asthma ever were stronger in the earlier part of the follow-up and among atopic children. No consistent associations were found between moisture damage with or without visible mold and atopic sensitization.CONCLUSIONS: Moisture damage and mold in early infancy in the child's main living areas were associated with asthma development. Atopic children may be more susceptible to the effects of moisture damage and mold.

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“…This method has previously been validated against the in vitro IgE CAP system (Pharmacia, Freiburg, Germany) and the skin prick test. 12 Food allergens included hen's egg, cow's milk, peanut, hazelnut, carrot, wheat flour, and soybean; inhalant allergens comprised Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, horse, dog, Alternaria species, mugwort, plantain, alder, birch pollen, hazel pollen, rye pollen, and a grass pollen mix. In addition, peripheral blood samples of the mothers were taken at birth (in Switzerland and Finland) or at a home visit when the child was 2 months old and were assessed for IgE levels.…”

Section: Specific Ige In Serum Samplesmentioning

confidence: 99%