Diagnostic and clinical role of serum proteinase 3 antineutrophil cytoplasmic antibodies in inflammatory bowel disease

Takedatsu, Hidetoshi; Mitsuyama, Keiichi; Fukunaga, Shuji; Yoshioka, Shinichiro; Yamauchi, Ryosuke; Mori, Atsushi; Yamasaki, Hiroshi; Kuwaki, Kotaro; Sakisaka, Hideto; Sakisaka, Shotaro; Torimura, Takuji

doi:10.1111/jgh.14140

Cited by 28 publications

(42 citation statements)

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“…Regarding EIA, CLEIA is reportedly more sensitive than ELISA for examinations of the same samples [24]. Although PR3-ANCA was measured using the same CLEIA method in the present study and by Takedatsu et al [10], other reports have not described the methods of measurement in detail. The differences in the positivity rates may be the result of differences in the measurement method.…”

Section: Discussionmentioning

confidence: 46%

“…The relationship between UC activity and PR3-ANCA remains controversial [10,20]. As stated previously, results of previous reports may have been impacted by differences in the methods used to measure PR3-ANCA, complications and the use of drugs.…”

Section: Discussionmentioning

confidence: 99%

“…The rate of positivity for PR3-ANCA in UC has been reported as 39.2% among Japanese individuals by Takedatsu et al [10]. In addition, it is reportedly 8.6% among Chinese individuals, 12.1% among Swedish individuals [20], and 14.1% among Spanish individuals [21].…”

Section: Discussionmentioning

confidence: 99%

“…As stated previously, results of previous reports may have been impacted by differences in the methods used to measure PR3-ANCA, complications and the use of drugs. Although Takedatsu et al [10]. reported that PR3-ANCA is related to UC activity, UC activity was assessed according to clinical activity.…”

Section: Discussionmentioning

confidence: 99%

“…MPO-ANCA is reportedly useful to differentiate UC from Crohn's disease because UC cases in Western countries are often positive for MPO-ANCA [7,8]. However, in Japan and other regions of Asia, UC cases are commonly positive for PR3-ANCA, not MPO-ANCA [9,10]. A multicenter, retrospective, observational study was conducted to elucidate the clinical signi cance of PR3-ANCA in UC.…”

Section: Introductionmentioning

confidence: 99%

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Serum anti-proteinase 3 anti-neutrophil cytoplasmic antibody in ulcerative colitis: a potential marker of disease activity that predicts steroid therapy failure

Aoyama

Inaba

Takahashi

et al. 2020

Preprint

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Background Serum anti-proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) is a disease-specific antibody against granulomatosis with polyangiitis. Some patients with ulcerative colitis (UC) have positive results for PR3-ANCA but the clinical significance of PR3-ANCA is not clear. Thus, we conducted a multicenter, retrospective, observational study to elucidate the clinical significance of PR3-ANCA in UC.Methods In total, 150 patients with UC underwent colonoscopy and serum PR3-ANCA measurements. Activity was evaluated using the Mayo Endoscopic Subscore (MES), and the relationship between activity and PR3-ANCA was analyzed.Results Twenty-six of the 150 patients who met the exclusion criteria were eliminated; 124 patients were included. A positive correlation was observed between MES and PR3-ANCA (r = 0.42; p < 0.001). Receiver-operating characteristic analysis showed that the cut-off value for calculations was 4.1 U/mL. Of 108 patients with active-phase UC, 58 (53.7%) were positive for PR3-ANCA. Furthermore, patients for whom steroid therapy was ineffective had a significantly higher rate of being PR3-ANCA positive (p = 0.045). Of 21 patients who reached clinical remission with PR3-ANCA-positive active-phase UC, 13 had an MES ≥ 1 and 8 patients had an MES 0. For MES 0 cases, the reduction of PR3-ANCA levels was significant (p = 0.012) when comparing the active-phase and clinical remission. All cases with MES 0 were negative for PR3-ANCA. Only 4 of 13 cases with MES ≥ 1 were negative for PR3-ANCA.Conclusions Approximately half of UC cases are PR3-ANCA-positive during the acute phase, indicating that PR3-ANCA is a potential marker of disease activity that predicts steroid therapy failure.Trial registration This study was registered in the UMIN Clinical Trials Registry System (000039174). Retrospectively registered on 16th Jan. 2020.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%