Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis

Abstract

In recent years, a rising number of studies have confirmed that microRNA (miRNA) plays a prominent role in the early diagnosis and prognostic value assessment of cardiovascular diseases. The current study was conducted to examine the expression of miR-675-3p in atherosclerosis (AS) patients and to evaluate its clinical diagnosis and prognostic value. 110 AS patients and 70 healthy controls were included in the study. Serum miR-675-3p levels were detected by quantitative real-time PCR (qRT-PCR). The clinical diagnostic significance of serum miR-675-3p in AS patients were investigated by the receiver operating characteristic (ROC) curve. The correlation between miRNA and carotid intima-media thickness (CIMT) was analyzed by the Spearman correlation coefficient. The prognostic significance of serum miR-675-3p was evaluated by the Kaplan-Meier method and Cox regression analysis. The patient’s serum miR-675-3p was significantly increased than the healthy individuals ( P < 0.05). An increase of carotid intima-media thickness (CIMT) was positively correlated with the promotion of serum miR-675-3p levels. The area under the ROC curve (AUC) was 0.918, with high sensitivity and specificity. miR-675-3p is a key independent predictor of cardiovascular adverse events in AS patients (HR = 5.375, 95%CI = 1.590-18.170, P = 0.007), and patients with elevated miR-675-3p were more likely to have cardiovascular adverse events (log-rank P = 0.030). Increased miR-675-3p can be used as a potential marker for the diagnosis of AS, and was associated with the poor prognosis of AS.

PCSK9i promoting the transformation of AS plaques into a stable plaque by targeting the miR-186-5p/Wipf2 and miR-375-3p/Pdk1/Yap1 in ApoE−/− mice

“…Previous studies have also demonstrated the involvement of these miRNAs in the regulation of lipid accumulation, energy metabolism, production of vascular inflammatory factors, and proliferation, migration, and apoptosis of endothelial and smooth muscle cells (35)(36)(37)(38)(39)(40)(41)(42)(43)(44),indicating their close…”

Structural Modifications and Novel Protein-Binding Sites in Pre-miR-675—Explaining Its Regulatory Mechanism in Carcinogenesis

“…Studies have shown that miR-675-3p (a mature form of miR-675) can promote colorectal cancer and esophageal squamous cell carcinoma and regulate skeletal muscle regeneration and differentiation [ 4 , 5 , 6 ]. Recently, an association between abnormal expression of pre-miR-675 and cardiovascular disease has also been identified [ 7 ]. Elevated levels of pre-miR-675 in the patient serum suffering from atherosclerosis highlight the need to use pre-miR-675 as a new diagnostic biomarker in early diagnosis of cardiovascular disorders [ 7 ].…”

“…Recently, an association between abnormal expression of pre-miR-675 and cardiovascular disease has also been identified [ 7 ]. Elevated levels of pre-miR-675 in the patient serum suffering from atherosclerosis highlight the need to use pre-miR-675 as a new diagnostic biomarker in early diagnosis of cardiovascular disorders [ 7 ]. Abnormal expression of pre-miR-675 has been linked to various neurological diseases.…”

Comprehensive structural and interactome analysis reveals novel interactions and protein binding sites in miR-675: a non-coding RNA critically involved in multiple diseases

“…Studies have also shown that miR-675-3p (a mature form of miR-675) can promote colorectal cancer, esophageal squamous cell carcinoma and regulate skeletal muscle regeneration and differentiation [4][5][6]. Recently, association between abnormal expression of miR-675 and cardiovascular disease have also been identified [7]. Elevated levels of miR-675 in the patient serum suffering from atherosclerosis highlights the need to use miR-675 as a new diagnostic biomarker in early diagnosis of cardiovascular disorder [7].…”

“…Recently, association between abnormal expression of miR-675 and cardiovascular disease have also been identified [7]. Elevated levels of miR-675 in the patient serum suffering from atherosclerosis highlights the need to use miR-675 as a new diagnostic biomarker in early diagnosis of cardiovascular disorder [7]. Abnormal expression of miR-675 has also been linked to various neurological diseases.…”